SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Xu Jun) "

Sökning: WFRF:(Xu Jun)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Birney, Ewan, et al. (författare)
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
  • 2007
  • Ingår i: Nature. - 1476-4687. ; 447:7146, s. 799-816
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
  •  
3.
  • Birney, Ewan, et al. (författare)
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
  • 2007
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
  •  
4.
  • Shi, Leming, et al. (författare)
  • The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
  • 2010
  • Ingår i: Nature Biotechnology. - Nature Publishing Group. - 1087-0156. ; 28:8, s. 827-838
  • Tidskriftsartikel (refereegranskat)abstract
    • Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.
  •  
5.
  • Wang, Guilei, et al. (författare)
  • Integration of Highly Strained SiGe in Source and Drain with HK and MG for 22 nm Bulk PMOS Transistors
  • 2017
  • Ingår i: Nanoscale Research Letters. - Springer. - 1931-7573. ; 12
  • Tidskriftsartikel (refereegranskat)abstract
    • In this study, the integration of SiGe selective epitaxy on source/drain regions and high-k and metal gate for 22 nm node bulk pMOS transistors has been presented. Selective Si1-xGex growth (0.35 <= x <= 0.40) with boron concentration of 1-3 x 10(20) cm(-3) was used to elevate the source/drain. The main focus was optimization of the growth parameters to improve the epitaxial quality where the high-resolution x-ray diffraction (HRXRD) and energy dispersive spectrometer (EDS) measurement data provided the key information about Ge profile in the transistor structure. The induced strain by SiGe layers was directly measured by x-ray on the array of transistors. In these measurements, the boron concentration was determined from the strain compensation of intrinsic and boron-doped SiGe layers. Finally, the characteristic of transistors were measured and discussed showing good device performance.
6.
  • Wuttke, Matthias, et al. (författare)
  • A catalog of genetic loci associated with kidney function from analyses of a million individuals
  • 2019
  • Ingår i: Nature Genetics. - NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
  •  
7.
  • Xu, Chun Kai, et al. (författare)
  • Nonlinear inelastic electron scattering revealed by plasmon-enhanced electron energy-loss spectroscopy
  • 2014
  • Ingår i: Nature Physics. - 1745-2473 .- 1745-2481. ; 10:10, s. 753-757
  • Tidskriftsartikel (refereegranskat)abstract
    • Electron energy-loss spectroscopy is a powerful tool for identifying the chemical composition of materials(1-5). It relies mostly on the measurement of inelastic electrons, which carry specific atomic or molecular information. Inelastic electron scattering, however, has a very low intensity, often orders of magnitude weaker than that of elastically scattered electrons. Here, we report the observation of enhanced inelastic electron scattering from silver nanostructures, the intensity of which can reach up to 60% of its elastic counterpart. A home-made scanning probe electron energy-loss spectrometer(6) was used to produce highly localized plasmonic excitations, significantly enhancing the strength of the local electric field of silver nanostructures. The intensity of inelastic electron scattering was found to increase nonlinearly with respect to the electric field generated by the tip-sample bias, providing direct evidence of nonlinear electron scattering processes.
  •  
8.
  •  
9.
  • An, Junghwa, et al. (författare)
  • Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009-30 November 2009
  • 2010
  • Ingår i: Molecular Ecology Resources. - 1755-098X. ; 10:2, s. 404-408
  • Tidskriftsartikel (refereegranskat)abstract
    • This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fischeri, Nothofagus pumilio, Onychodactylus fischeri, Phoenicopterus roseus, Salvia officinalis L., Scylla paramamosain, Silene latifo, Sula sula, and Vulpes vulpes. These loci were cross-tested on the following species: Aspergillus giganteus, Colias pelidne, Colias interior, Colias meadii, Colias eurytheme, Coryphopterus lipernes, Coryphopterus glaucofrenum, Coryphopterus eidolon, Gnatholepis thompsoni, Elacatinus evelynae, Dendrobium loddigesii Dendrobium devonianum, Dysoxylum binectariferum, Nothofagus antarctica, Nothofagus dombeyii, Nothofagus nervosa, Nothofagus obliqua, Sula nebouxii, and Sula variegata. This article also documents the addition of 39 sequencing primer pairs and 15 allele specific primers or probes for Paralithodes camtschaticus.
  •  
10.
  • Bäckhed, Fredrik, 1973-, et al. (författare)
  • Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
  • 2015
  • Ingår i: Cell Host & Microbe. - 1931-3128. ; 17:5, s. 690-703
  • Tidskriftsartikel (refereegranskat)abstract
    • The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life. © 2015 Elsevier Inc.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (46)
Typ av publikation
tidskriftsartikel (171)
konferensbidrag (8)
forskningsöversikt (4)
annan publikation (2)
Typ av innehåll
refereegranskat (177)
övrigt vetenskapligt (10)
Författare/redaktör
Xu, Ning, (23)
Zhang, Jun (19)
Metspalu, Andres (12)
Nilsson-Ehle, Peter, (10)
Boehnke, Michael (10)
Mohlke, Karen L (10)
visa fler...
Esko, Tonu (9)
Morris, Andrew P. (9)
Lindgren, Cecilia M. (9)
Peters, Annette (8)
Loos, Ruth J. F. (8)
Lind, Lars, (7)
Froguel, Philippe, (7)
Melander, Olle, (7)
Uitterlinden, Andre ... (7)
Kuusisto, Johanna, (7)
Laakso, Markku, (7)
McCarthy, Mark I (7)
Langenberg, Claudia (7)
Scott, Robert A (7)
Gieger, Christian (7)
Strauch, Konstantin (7)
Elliott, Paul (7)
Meitinger, Thomas (7)
Collins, Francis S. (7)
Stefansson, Kari (7)
He, Sailing, (7)
Zeggini, Eleftheria (7)
Milani, Lili, (7)
Yu, Yang (6)
Cheng, Ching -Yu, (6)
Martin, Nicholas G., (6)
Wareham, Nicholas J. (6)
Hansson, Lars-Anders ... (6)
Stancáková, Alena, (6)
Linneberg, Allan, (6)
Grarup, Niels, (6)
Pedersen, Oluf, (6)
Hansen, Torben, (6)
Liu, Jianjun (6)
Salomaa, Veikko (6)
Janson, Jan-Christer ... (6)
Hattersley, Andrew T (6)
Hayward, Caroline (6)
Perry, John R. B. (6)
Stringham, Heather M ... (6)
Frayling, Timothy M. (6)
Rao, K. Venkat, (6)
Kapilashrami, Mukes, (6)
Wilson, James G. (6)
visa färre...
Lärosäte
Lunds universitet (53)
Uppsala universitet (53)
Kungliga Tekniska Högskolan (37)
Karolinska Institutet (21)
Umeå universitet (20)
Linköpings universitet (12)
visa fler...
Stockholms universitet (10)
Göteborgs universitet (9)
Luleå tekniska universitet (7)
Chalmers tekniska högskola (6)
Högskolan Dalarna (3)
Malmö universitet (2)
Högskolan i Halmstad (2)
Örebro universitet (1)
Högskolan i Jönköping (1)
Mittuniversitetet (1)
RISE (1)
visa färre...
Språk
Engelska (182)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (81)
Medicin och hälsovetenskap (67)
Teknik (38)
Samhällsvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy