| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Yeung, Andy Wai Kan, et al.
(författare)
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Resveratrol, a popular dietary supplement for human and animal health : Quantitative research literature analysis - a review
- 2019
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Ingår i: Animal Science Papers and Reports. - : POLSKA AKAD NAUK, INST GENETYKI I HODOWLI ZWIERZAT. - 0860-4037. ; 37:2, s. 103-118
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Forskningsöversikt (refereegranskat)abstract
- Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=("resveratrol*") and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. 'I'he ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins.
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| 3. |
- Ba, Kun, et al.
(författare)
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Billiard Catalysis at Ti3C2 MXene/MAX Heterostructure for Efficient Nitrogen Fixation
- 2022
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Ingår i: Applied Catalysis B. - : Elsevier BV. - 0926-3373 .- 1873-3883. ; 317, s. 121755-
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Tidskriftsartikel (refereegranskat)abstract
- Electrocatalytic ammonia (NH3) conversion under ambient atmosphere is crucial to mimic the nature's nitrogen cycle. But currently it is always interrupted by the HER process which is more competitive. Herein, we tactically cultivate a series of incompletely etched Ti3AlC2 MAX / Ti3C2 MXene based heterostructure catalysts whose composition can be finely tuned through regulation of the LiF percentage in mixed chemical etching agent. Notably, the surface potential difference between MAX and MXene is ~40 mV, indicating that the electron can be readily transferred from MAX to MXene across the interfaces, which is favorable for N2 fixation, yielding an outstanding Faradic efficiency of 36.9%. Furthermore, density functional theory calculations reveal the billiard-like catalysis mechanism, where the intermediates are alternatively adsorbed on MAX or MXene surfaces. Meanwhile, the rate-determining step of *NH → *NH2 possesses an energy barrier of 0.96 eV on the hetero-interface which follows associative distal mechanism. This work opens a new frontier of heterostructured catalyst for balancing electrical conductivity and catalytic activity in electrocatalysis.
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| 4. |
- Chen, Xue, et al.
(författare)
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Co-Doped Fe3S4Nanoflowers for Boosting Electrocatalytic Nitrogen Fixation to Ammonia under Mild Conditions
- 2022
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Ingår i: Inorganic Chemistry. - : American Chemical Society. - 0020-1669 .- 1520-510X. ; 61:49, s. 20123-20132
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Tidskriftsartikel (refereegranskat)abstract
- Compared with the Haber Bosch process, the electrochemical nitrogen reduction reaction (NRR) under mild conditions provides an alternative and promising route for ammonia synthesis due to its green and sustainable features. However, the great energy barrier to break the stable NN bond hinders the practical application of NRR. Though Fe is the only common metal element in all biological nitrogenases in nature, there is still a lack of study on developing highly efficient and low-cost Fe-based catalysts for N2fixation. Herein, Co-doped Fe3S4nanoflowers were fabricated as the intended catalyst for NRR. The results indicate that 4% Co-doped Fe3S4nanoflowers achieve a high Faradaic efficiency of 17% and a NH3yield rate of 37.5 μg·h-1·mg-1cat.at-0.55 V versus RHE potential in 0.1 M HCl, which is superior to most Fe-based catalysts. The introduction of Co atoms can not only shift the partial density states of Fe3S4toward the Fermi level but also serve as new active centers to promote N2absorption, lowering the energy barrier of the potential determination step to accelerate the catalytic process. This work paves a pathway of the morphology and doping engineering for Fe-based electrocatalysts to enhance ammonia synthesis.
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| 5. |
- Gao, Hong, et al.
(författare)
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The landscape of tolerated genetic variation in humans and primates
- 2023
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6648
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Tidskriftsartikel (refereegranskat)abstract
- Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole-genome sequencing data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these variants can be inferred to have nondeleterious effects in humans based on their presence at high allele frequencies in other primate populations. We use this resource to classify 6% of all possible human protein-altering variants as likely benign and impute the pathogenicity of the remaining 94% of variants with deep learning, achieving state-of-the-art accuracy for diagnosing pathogenic variants in patients with genetic diseases.
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| 6. |
- Liu, Yang, et al.
(författare)
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Investigation on residual stress evolution in nickel-based alloy affected by multiple cutting operations
- 2021
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Ingår i: Journal of Manufacturing Processes. - : Elsevier BV. - 1526-6125. ; 68, s. 818-833
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Tidskriftsartikel (refereegranskat)abstract
- Machining-induced residual stresses in a part can significantly influence its performance and service time. It is common that the final surface of the part is produced after multiple cuts in the machining process. In multiple cuts, the previous cuts could often generate accumulated strain/stress and temperature on the part surface. These accumulated strain/stress and temperature will be brought to the subsequent cut or final cut and continuously affect the cutting forces, process temperatures, deformation zones, etc. in subsequent cut, and eventually affect the final residual stresses on the part. This paper reports on a joint experimental and numerical investigation to explore the influence of previous cuts on surface residual stresses with consideration of cutting parameters, cutting procedure, and tool geometries in multiple cut of Inconel 718 alloy. Coupled Eulerian and Lagrangian (CEL) formulation is used in a two/three-cuts numerical model. The loading cycles of the selected material nodes are characterised based on isotropic constitutive model (Johnson-Cook model) to analyse the underlying mechanism of residual stress evolution during cutting sequences. The results show that accumulated stress/strain induced by previous cuts lead to a more curled chip morphology, a slight decrease in cutting force and a slight increase in feed force in the subsequent cut. An increased magnitude and depth of compressive residual stresses in the finished workpiece are generated owing to the influence of previous cuts, and this is more obvious when the previous cut is implemented at a larger uncut chip thickness, using a more negative rake angle or a larger edge radius tool. The residual stress level might be controlled by optimizing the previous cuts to get the desired surface integrity.
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| 7. |
- Liu, Yang, et al.
(författare)
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Numerical and experimental investigation of tool geometry effect on residual stresses in orthogonal machining of Inconel 718
- 2021
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Ingår i: Simulation Modelling Practice and Theory. - : Elsevier BV. - 1569-190X. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- Residual stress has become more important than ever with the increasing performance requirement of components especially for those applied in safety-critical areas. As the machining process is fundamentally correlated with the acquired component properties, it is essential to fully understand the formation mechanism of residual stresses in the cutting process and its influence on the performance of the component. This paper presents results based on numerical and experimental analysis on the effect of tool geometry on thermal-mechanical load and residual stresses in orthogonal machining Inconel718 alloy. The Coupled Eulerian-Lagrangian (CEL) method is used to simulate the effect of tool geometry on temperatures, forces, equivalent plastic strains, and residual stresses. The local normal/tangential stress is introduced to determine the degree of the tensile plastic deformation induced by the tool. It is observed that a negative rake angle and a sharp edge radius tool tend to generate more compressive stress on the machined surface than the ones generated with positive rake angle tools and/or lager edge radius. Besides, an increase in flank wear produces less magnitude of compressive stress in subsurface due to a decreased local normal stress caused by increased flank contact length.
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| 8. |
- Liu, Yang, et al.
(författare)
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Numerical contribution to segmented chip effect on residual stress distribution in orthogonal cutting of Inconel718
- 2020
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Ingår i: International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 109, s. 993-1005
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Tidskriftsartikel (refereegranskat)abstract
- Segmented chip morphology has a significant influence on distribution of residual stress and surface topography on machined surface in machining difficult-to-cut materials. In this paper, Coupled Eulerian and Lagrangian (CEL) model is employed to investigate the effect of segmented chip on surface integrity (residual stress distribution and surface topography) in orthogonal machining of Inconel718 with uncoated carbide inserts. A mesh sensitivity study of chip morphology and residual stress distribution is performed by developing the following three different grid resolutions: coarse (mesh size 35 μm), medium (10 μm) and fine (5 μm). Comparing with the experimental results, it is clear that the numerical model presents reasonable results, including the chip morphology, temperature distribution, cutting forces, residual stress profile and surface fluctuation period. As for the generated surface integrity, a waved surface and cyclic residual stress distribution are found with the segmented chip due to the periodical mechanical and thermal loadings acting on the machined surface. Furthermore, the formation of single chip segment is investigated in-depth to explain the residual stress distribution generation.
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| 9. |
- Weng, Jian, et al.
(författare)
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An analytical method for continuously predicting mechanics and residual stress in fillet surface turning
- 2021
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Ingår i: Journal of Manufacturing Processes. - : Elsevier BV. - 1526-6125. ; 68, s. 1860-1879
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Tidskriftsartikel (refereegranskat)abstract
- A novel and effective approach for determining mechanics and residual stress when turning a component with curved surfaces is presented in this paper. This predictive approach is based on a three-dimensional analytical model to study the distributed mechanics and residual stress caused by vary cutting condition during the machining process. The variation of uncut chip area in this process can be divided into several stages based on different tool-workpiece contact and the discretization of cutting edge is conducted at an arbitrary tool position. The chip flow direction is calculated through the equilibrium of the incremental interaction forces. The cutting force can be determined by integrating the force components along the cutting edge, with each incremental force component obtained based on a fully analytical model. Distributed heat source intensity is considered to model the temperature rise at an arbitrary point in workpiece. The residual stress in curved surface machining is obtained considering the loading-unloading-relaxation procedure at the engagement of cutting edge and machined surface. Finally, Finite Element (FE) modeling and experiments are performed to validate the correctness and robustness of the analytical model proposed in this paper. The results of predicted chip flow direction, cutting force, temperature, and residual stress show good agreement with the simulated and measured results.
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| 10. |
- Xu, Dongdong, et al.
(författare)
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Investigation of the influence of tool rake angles on machining of inconel 718
- 2021
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Ingår i: Journal of Manufacturing and Materials Processing. - : MDPI AG. - 2504-4494. ; 5:3
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Tidskriftsartikel (refereegranskat)abstract
- It is essential for superalloys (e.g., Inconel 718) to obtain an anticipated surface integrity after machining, especially for safety critical areas (e.g., aerospace). As one of the main characteristics for cutting tools, the rake angle has been recognized as a key factor that can significantly influence the machining process. Although there are large research interests and outcomes in the machining of nickel-based superalloys, most of them focus on the surface integrity and macroscale temperature observation, whereas the temperature distribution in the tool rake face is not clear. Thus, it is necessary to investigate the basic role of rake angles and the tool–workpiece interaction mechanism to determine the machining condition variations and surface integrity. In the present study, both experimental and numerical methods are employed to explore the cutting force, thermal distribution, and shear angles during the process and the metallurgy characteristics of the subsurface after machining, as well as the mechanical properties. The research has emphasized the importance of rake angles on both the cutting process and machined surface integrity, and has revealed the microscale temperature distribution in the tool rake face, which is believed to have a close relationship with the tool crater wear. In addition, it is clearly presented that the surface generated with positive rake angle tools generates the minimum subsurface deformation and less strain hardening on the workpiece.
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