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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 4. |
- Lei, Lei, et al.
(författare)
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Load Coupling and Energy Optimization in Multi-Cell and Multi-Carrier NOMA Networks
- 2019
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Ingår i: IEEE Transactions on Vehicular Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9545 .- 1939-9359. ; 68:11, s. 11323-11337
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we investigate energy optimization in multi-cell and multi-carrier non-orthogonal multiple access (NOMA) networks. We apply a load-coupling model for NOMA networks to capture the coupling relation of mutual interference among cells. With this analytical tool, we formulate an energy minimization problem in a NOMA-based load-coupled system, where optimizing load-rate-power allocation, and determining decoding order and user grouping are the key aspects. Theoretically, we prove that the minimum consumed energy can be achieved by using all the time-frequency resources in each cell to deliver users' demand, and allowing all the users to share resource units. From a practical perspective, we consider three types of NOMA grouping schemes, i.e., all-user grouping, partitioned and non-partitioned grouping. We develop tailored solutions for each grouping scheme to enable efficient load-rate-power optimization. These three algorithmic components are embedded into a power-adjustment framework to provide energy-efficient solutions for NOMA networks. Numerical results demonstrate promising energy-saving gains of NOMA over orthogonal multiple access in large-scale cellular networks, in particular for high-demand and resource-limited scenarios. The results also show fast convergence of the proposed algorithms and demonstrate the effectiveness of the solutions.
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| 5. |
- You, Lei, et al.
(författare)
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A Framework for Optimizing Multi-cell NOMA : Delivering Demand with Less Resource
- 2017
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Ingår i: GLOBECOM 2017 - 2017 IEEE Global Communications Conference. - : IEEE. - 9781509050192
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Konferensbidrag (refereegranskat)abstract
- Non-orthogonal multiple access (NOMA) allows multiple users to simultaneously access the same time-frequency resource by using superposition coding and successive interference cancellation (SIC). Thus far, most papers on NOMA have focused on performance gain for one or sometimes two base stations. In this paper, we study multi-cell NOMA and provide a general framework for user clustering and power allocation, taking into account inter-cell interference, for optimizing resource allocation of NOMA in multi-cell networks of arbitrary topology. We provide a series of theoretical analysis, to algorithmically enable optimization approaches. The resulting algorithmic notion is very general. Namely, we prove that for any performance metric that monotonically increases in the cells' resource consumption, we have convergence guarantee for global optimum. We apply the framework with its algorithmic concept to a multi-cell scenario to demonstrate the gain of NOMA in achieving significantly higher efficiency.
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| 6. |
- You, Lei, et al.
(författare)
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A Performance Study of Energy Minimization for Interleaved and Localized FDMA
- 2014
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Ingår i: 2014 IEEE 19TH INTERNATIONAL WORKSHOP ON COMPUTER AIDED MODELING AND DESIGN OF COMMUNICATION LINKS AND NETWORKS (CAMAD). - : IEEE. - 9781479957255 ; , s. 16-20
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Konferensbidrag (refereegranskat)abstract
- Optimal channel allocation is a key performance engineering aspect in single-carrier frequency-division multiple access (SC-FDMA). It is of significance to consider minimum sum power (Min-Power), subject to meeting specified users demand, since mobile users typically employ battery-powered handsets. In this paper, we prove that Min-Power is polynomial-time solvable for interleaved SC-FDMA (IFDMA). Then we propose a channel allocation algorithm for IFDMA, which is guaranteed to achieve global optimum in polynomial time. We numerically compare the proposed algorithm with optimal localized SC-FDMA (LFDMA) for Min-Power. The results show that LFDMA outperforms IFDMA in the maximal supported user demand. When the user demand can be satisfied in both LFDMA and IFDMA, LFDMA performs slightly better than IFDMA. However MinPower is polynomial-time solvable for IFDMA whereas it is not for LFDMA.
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| 7. |
- You, Lei, et al.
(författare)
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Efficient Minimum-Energy Scheduling with Machine-Learning Based Predictions for Multiuser MISO Systems
- 2018
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Ingår i: 2018 IEEE International Conference on Communications (ICC). - : IEEE. - 9781538631805 - 9781538631812 ; , s. 1-6
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Konferensbidrag (refereegranskat)abstract
- We address an energy-efficient scheduling problem for practical multiple-input single-output (MISO) systems with stringent execution-time requirements. Optimal user-group scheduling is adopted to enable timely and energy-efficient data transmission, such that all the users' demand can be delivered within a limited time. The high computational complexity in optimal iterative algorithms limits their applications in real-time network operations. In this paper, we rethink the conventional optimization algorithms, and embed machine-learning based predictions in the optimization process, aiming at improving the computational efficiency and meeting the stringent execution-time limits in practice, while retaining competitive energy-saving performance for the MISO system. Numerical results demonstrate that the proposed method, i.e., optimization with machine- learning predictions (OMLP), is able to provide a time-efficient and high-quality solution for the considered scheduling problem. Towards online scheduling in real-time communications, OMLP is of high computational efficiency compared to conventional optimal iterative algorithms. OMLP guarantees the optimality as long as the machine- learning based predictions are accurate.
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| 8. |
- You, Lei, et al.
(författare)
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Load Balancing via Joint Transmission in Heterogeneous LTE: Modeling and Computation
- 2015
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Ingår i: 2015 IEEE 26TH ANNUAL INTERNATIONAL SYMPOSIUM ON PERSONAL, INDOOR, AND MOBILE RADIO COMMUNICATIONS (PIMRC). - : IEEE. - 9781467367820 ; , s. 1173-1177
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Konferensbidrag (refereegranskat)abstract
- As one of the Coordinated Multipoint (CoMP) techniques, Joint Transmission (JT) can improve the overall system performance. In this paper, from the load balancing perspective, we study how the maximum load can be reduced by optimizing JT pattern that characterizes the association between cells and User Equipments (UEs). To give a model of the interference caused by cells with different time-frequency resource usage, we extend a load coupling model, by taking into account JT. In this model, the mutual interference depends on the load of cells coupled in a non-linear system with each other. Under this model, we study a two-cell case and proved that the optimality is achieved in linear time in the number of UEs. After showing the complexity of load balancing in the general network scenario, an iterative algorithm for minimizing the maximum load, named JT-MinMax, is proposed. We evaluate JT-MinMax in a heterogeneous Network (HetNet), though it is not limited to this type of scenarios. Numerical results demonstrate the significant performance improvement of JT-MinMax on min-max cell load, compared to the conventional non-JT solution where each UE is served by the cell with best received transmit signal.
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| 9. |
- You, Lei, et al.
(författare)
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Optimizing Power and User Association for Energy Saving in Load-Coupled Cooperative LTE
- 2016
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Ingår i: 2016 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC). - : IEEE. - 9781479966646
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Konferensbidrag (refereegranskat)abstract
- We consider an energy minimization problem for cooperative LTE networks. To reduce energy consumption, we investigate how to jointly optimize the transmit power and the association between cells and user equipments (UEs), by taking into consideration joint transmission (JT), one of the coordinated multipoint (CoMP) techniques. We formulate the optimization problem mathematically. For solving the problem, a dynamic power allocation algorithm that adjusts the transmit power of all cells, and an algorithm for optimizing the cell-UE association, are proposed. The two algorithms are iteratively used in an algorithmic framework to enhance the energy performance. Numerically, the proposed algorithms can lead to lower energy consumption than the optimal energy setting in the non-JT case. In comparison to fixed power allocation in JT, the proposed dynamic power allocation algorithm is able to significantly reduce the energy consumption.
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| 10. |
- Ablikim, M., et al.
(författare)
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Amplitude analysis of the chi(c1) -> eta pi(+)pi(-) decays
- 2017
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:3
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Tidskriftsartikel (refereegranskat)abstract
- Using 448.0 x 10(6) psi(3686) events collected with the BESIII detector, an amplitude analysis is performed for psi(3686) -> gamma chi(c1), chi(c1) ->eta pi(+)pi(-) decays. The most dominant two- body structure observed is a(0)(980)(+/-) pi(-/+); a(0)(980)(+/-) -> eta pi(+/-.) line shape is modeled using a dispersion relation, and a significant nonzero a(0) (980) coupling to the eta'pi channel is measured. We observe chi(c1) -> a(2)(1700)pi production for the first time, with a significance larger than 17 sigma. The production of mesons with exotic quantum numbers, J(PC) = 1(-+), is investigated, and upper limits for the branching fractions chi(c1) -> pi(1)(1400)(+/-)pi(-/+) , chi(c1) -> pi(1)(1600)(+/-)pi(-/+) and chi(c1) -> pi 1(2015)(+/-)pi(-/+) with subsequent pi(1)(X)(+/-) -> eta pi(+/-) decay, are determined.
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