SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Yu Le) "

Sökning: WFRF:(Yu Le)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Landes Bioscience. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
  •  
3.
  • Aad, G., et al. (författare)
  • A neural network clustering algorithm for the ATLAS silicon pixel detector
  • 2014
  • Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • A novel technique to identify and split clusters created by multiple charged particles in the ATLAS pixel detector using a set of artificial neural networks is presented. Such merged clusters are a common feature of tracks originating from highly energetic objects, such as jets. Neural networks are trained using Monte Carlo samples produced with a detailed detector simulation. This technique replaces the former clustering approach based on a connected component analysis and charge interpolation. The performance of the neural network splitting technique is quantified using data from proton-proton collisions at the LHC collected by the ATLAS detector in 2011 and from Monte Carlo simulations. This technique reduces the number of clusters shared between tracks in highly energetic jets by up to a factor of three. It also provides more precise position and error estimates of the clusters in both the transverse and longitudinal impact parameter resolution.
  •  
4.
  • Aad, G., et al. (författare)
  • Electron reconstruction and identification efficiency measurements with the ATLAS detector using the 2011 LHC proton-proton collision data
  • 2014
  • Ingår i: European Physical Journal C. Particles and Fields. - : Springer. - 1434-6044 .- 1434-6052. ; 74:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Many of the interesting physics processes to be measured at the LHC have a signature involving one or more isolated electrons. The electron reconstruction and identification efficiencies of the ATLAS detector at the LHC have been evaluated using proton-proton collision data collected in 2011 at TeV and corresponding to an integrated luminosity of 4.7 fb. Tag-and-probe methods using events with leptonic decays of and bosons and mesons are employed to benchmark these performance parameters. The combination of all measurements results in identification efficiencies determined with an accuracy at the few per mil level for electron transverse energy greater than 30 GeV.
  •  
5.
  • Aad, G, et al. (författare)
  • Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector.
  • 2014
  • Ingår i: Physical Review Letters. - : American Physical Society. - 1079-7114. ; 113:14
  • Tidskriftsartikel (refereegranskat)abstract
    • This Letter presents the first study of W^{±}W^{±}jj, same-electric-charge diboson production in association with two jets, using 20.3 fb^{-1} of proton-proton collision data at sqrt[s]=8 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two reconstructed same-charge leptons (e^{±}e^{±}, e^{±}μ^{±}, and μ^{±}μ^{±}) and two or more jets are analyzed. Production cross sections are measured in two fiducial regions, with different sensitivities to the electroweak and strong production mechanisms. First evidence for W^{±}W^{±}jj production and electroweak-only W^{±}W^{±}jj production is observed with a significance of 4.5 and 3.6 standard deviations, respectively. The measured production cross sections are in agreement with standard model predictions. Limits at 95% confidence level are set on anomalous quartic gauge couplings.
  •  
6.
  • Aad, G., et al. (författare)
  • Flavor tagged time-dependent angular analysis of the B-s(0) -> J/psi phi decay and extraction of Delta Gamma(s) and the weak phase phi(s) in ATLAS
  • 2014
  • Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - : American Physical Society. - 1550-2368 .- 1550-7998. ; 90:5
  • Tidskriftsartikel (refereegranskat)abstract
    • A measurement of the B-s(0) -> J/psi phi decay parameters, updated to include flavor tagging is reported using 4.9 fb(-1) of integrated luminosity collected by the ATLAS detector from root s = 7 TeV pp collisions recorded in 2011 at the LHC. The values measured for the physical parameters are phi(s) = 0.12 +/- 0.25(stat) +/- 0.05(syst) rad Delta Gamma(s) = 0.053 +/- 0.021(stat) +/- 0.010(syst) ps(-1) Gamma(s) = 0.677 +/- 0.007(stat) +/- 0.004(syst) ps(-1) vertical bar A(parallel to)(0)vertical bar(2) = 0.220 +/- 0.008(stat) +/- 0.009(syst) vertical bar A(0)(0)vertical bar(2) = 0.529 +/- 0.006(stat) +/- 0.012(syst) delta(perpendicular to) = 3.89 +/- 0.47(stat) +/- 0.11(syst) rad where the parameter Delta Gamma(s) is constrained to be positive. The S-wave contribution was measured and found to be compatible with zero. Results for phi(s) and Delta Gamma(s) are also presented as 68% and 95% likelihood contours, which show agreement with the Standard Model expectations.
  •  
7.
  • Aad, G., et al. (författare)
  • Light-quark and gluon jet discrimination in collisions at root s=7 TeV with the ATLAS detector
  • 2014
  • Ingår i: European Physical Journal C. Particles and Fields. - : Springer. - 1434-6044 .- 1434-6052. ; 74:8
  • Tidskriftsartikel (refereegranskat)abstract
    • A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built and validated using 4.7 fb of proton-proton collision data at collected with the ATLAS detector at the LHC. Data samples with enriched quark or gluon content are used in the construction and validation of templates of jet properties that are the input to the likelihood-based discriminant. The discriminating power of the jet tagger is established in both data and Monte Carlo samples within a systematic uncertainty of 10-20 %. In data, light-quark jets can be tagged with an efficiency of while achieving a gluon-jet mis-tag rate of in a range between and for jets in the acceptance of the tracker. The rejection of gluon-jets found in the data is significantly below what is attainable using a Pythia 6 Monte Carlo simulation, where gluon-jet mis-tag rates of 10 % can be reached for a 50 % selection efficiency of light-quark jets using the same jet properties.
  •  
8.
  • Aad, G., et al. (författare)
  • Measurement of event-plane correlations in root s(NN)=2.76 TeV lead-lead collisions with the ATLAS detector
  • 2014
  • Ingår i: Physical Review C (Nuclear Physics). - : American Physical Society. - 0556-2813 .- 1089-490X. ; 90:2
  • Tidskriftsartikel (refereegranskat)abstract
    • A measurement of event-plane correlations involving two or three event planes of different order is presented as a function of centrality for 7 mu b(-1) Pb + Pb collision data at v root s(NN) = 2.76 TeV, recorded by the ATLAS experiment at the Large Hadron Collider. Fourteen correlators are measured using a standard event-plane method and a scalar-product method, and the latter method is found to give a systematically larger correlation signal. Several different trends in the centrality dependence of these correlators are observed. These trends are not reproduced by predictions based on the Glauber model, which includes only the correlations from the collision geometry in the initial state. Calculations that include the final-state collective dynamics are able to describe qualitatively, and in some cases also quantitatively, the centrality dependence of the measured correlators. These observations suggest that both the fluctuations in the initial geometry and the nonlinear mixing between different harmonics in the final state are important for creating these correlations in momentum space.
  •  
9.
  • Aad, G., et al. (författare)
  • Measurement of inclusive jet charged-particle fragmentation functions in Pb plus Pb collisions at root S-NN=2.76 TeV with the ATLAS detector
  • 2014
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier. - 0370-2693 .- 1873-2445. ; 739, s. 320-342
  • Tidskriftsartikel (refereegranskat)abstract
    • Measurements of charged-particle fragmentation functions of jets produced in ultra-relativistic nuclear collisions can provide insight into the modification of parton showers in the hot, dense medium created in the collisions. ATLAS has measured jets in root S-NN = 2.76 TeV Pb+Pb collisions at the LHC using a data set recorded in 2011 with an integrated luminosity of 0.14 nb(-1). Jets were reconstructed using the anti-k(t) algorithm with distance parameter values R = 0.2, 0.3, and 0.4. Distributions of charged-particle transverse momentum and longitudinal momentum fraction are reported for seven bins in collision centrality for R = 0.4 jets with p(T)(jet) > 100 GeV. Commensurate minimum p(T) values are used for the other radii. Ratios of fragment distributions in each centrality bin to those measured in the most peripheral bin are presented. These ratios show a reduction of fragment yield in central collisions relative to peripheral collisions at intermediate z values, 0.04 less than or similar to z less than or similar to 0.2, and an enhancement in fragment yield for z less than or similar to 0.04. A smaller, less significant enhancement is observed at large z and large p(T) in central collisions. (C) 2014 The Authors. Published by Elsevier B.V.
  •  
10.
  • Aad, G., et al. (författare)
  • Measurement of the centrality and pseudorapidity dependence of the integrated elliptic flow in lead-lead collisions at root S-NN=2.76 TeV with the ATLAS detector
  • 2014
  • Ingår i: European Physical Journal C. Particles and Fields. - : Springer. - 1434-6044 .- 1434-6052. ; 74:8
  • Tidskriftsartikel (refereegranskat)abstract
    • The integrated elliptic flow of charged particles produced in Pb+Pb collisions at root S-NN = 2.76 TeV has been measured with the ATLAS detector using data collected at the Large Hadron Collider. The anisotropy parameter, upsilon(2), was measured in the pseudorapidity range |eta| <= 2.5 with the event-plane method. In order to include tracks with very low transverse momentum p(T), thus reducing the uncertainty in upsilon(2) integrated over p(T), a 1 mu b(-1) data sample recorded without a magnetic field in the tracking detectors is used. The centrality dependence of the integrated upsilon(2) is compared to other measurements obtained with higher PT thresholds. The integrated elliptic flow is weakly decreasing with |eta|. The integrated upsilon 2 transformed to the rest frame of one of the colliding nuclei is compared to the lower-energy RHIC data.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (807)
konferensbidrag (9)
forskningsöversikt (7)
proceedings (redaktörskap) (1)
annan publikation (1)
Typ av innehåll
refereegranskat (817)
övrigt vetenskapligt (8)
Författare/redaktör
Aad, G (569)
Zwalinski, L. (510)
Schmitt, C. (504)
Lee, S. C. (502)
Kim, S. H. (501)
Lokajicek, M. (500)
visa fler...
Garcia, C. (499)
De, K. (498)
Evans, H. (498)
Hill, J. C. (498)
Fox, H. (496)
Jakobs, K. (496)
Meyer, J. (496)
Quadt, A. (496)
Vartapetian, A. (496)
Burdin, S. (495)
Busato, E. (495)
Butler, J. M. (495)
Caron, S. (495)
Cheu, E. (495)
Haas, A. (495)
Kehoe, R. (495)
Kupco, A. (495)
Neal, H. A. (495)
Piegaia, R. (495)
Pleier, M. -A. (495)
Schaile, D. (495)
Schwartzman, A. (495)
Vachon, B. (495)
Borissov, G. (494)
Bos, K. (494)
Brandt, A. (494)
Burke, S. (494)
Chakraborty, D. (494)
Cooke, M. (494)
Feligioni, L. (494)
Fiedler, F. (494)
Hauser, R. (494)
Lounis, A. (494)
Lubatti, H. J. (494)
Moore, R. W. (494)
Pope, B. G. (494)
Qian, J. (494)
Sawyer, L. (494)
Simak, V. (494)
Snyder, S. (494)
Talby, M. (494)
Trefzger, T. (494)
Vreeswijk, M. (494)
White, A. (494)
visa färre...
Lärosäte
Lunds universitet (589)
Kungliga Tekniska Högskolan (470)
Uppsala universitet (130)
Karolinska Institutet (106)
Umeå universitet (56)
Stockholms universitet (22)
visa fler...
Göteborgs universitet (16)
Chalmers tekniska högskola (16)
Högskolan Dalarna (10)
Linköpings universitet (9)
Jönköping University (5)
Luleå tekniska universitet (4)
Linnéuniversitetet (3)
Örebro universitet (2)
Mittuniversitetet (2)
Mälardalens högskola (1)
Södertörns högskola (1)
visa färre...
Språk
Engelska (825)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (632)
Medicin och hälsovetenskap (134)
Teknik (12)
Lantbruksvetenskap (3)
Samhällsvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy