| 1. |
- Alterbeck, Max, et al.
(författare)
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A pilot study of an organised population-based testing programme for prostate cancer
- 2024
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Ingår i: BJU International. - 1464-4096. ; 133:1, s. 87-95
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo determine the feasibility of a digitally automated population-based programme for organised prostate cancer testing (OPT) in Southern Sweden.Patients and MethodsA pilot project for a regional OPT was conducted between September 2020 and February 2021, inviting 999 randomly selected men aged 50, 56, or 62 years. Risk stratification was based on prostate-specific antigen (PSA) level, PSA density (PSAD), and bi-parametric prostate magnetic resonance imaging (MRI). Men with a PSA level of 3-99 ng/mL had an MRI, and men with elevated PSA level (& GE;3 ng/mL) had a urological check-up, including a digital rectal examination and transrectal ultrasonography (TRUS). Indications for targeted and/or systematic transrectal prostate biopsies were suspicious lesions on MRI (Prostate Imaging-Reporting and Data System [PI-RADS] 4-5) and/or PSAD > 0.15 ng/mL/mL. Additional indications for prostate biopsies were palpable tumours, PSA ratio < 0.1, or cancer suspicion on TRUS. Patient selection, mail correspondence, data collection, and algorithm processing were performed by an automated digital management system. Feasibility is reported descriptively.ResultsA total of 418 men had a PSA test (42%), with increasing participation rates by age (50 years, 38%; 56 years, 44%; and 62 years, 45%). Among these, 35 men (8%) had elevated PSA levels (& GE;3 ng/mL: one of 139, aged 50 years; 10/143, aged 56 years; and 24/146, aged 62 years). On MRI, 16 men (48%) had a negative scan (PI-RADS < 3), seven men (21%) had PI-RADS 3, nine men (27%) had PI-RADS 4, and one man (3%) had PI-RADS 5. All men with PI-RADS 4 or 5 underwent prostate biopsies, as well as two men with PI-RADS 3 due to PSAD > 0.15 ng/mL/mL or a suspicious finding on TRUS. Prostate cancer was diagnosed in 10 men. Six men underwent active treatment, whereas four men were assigned to active surveillance.ConclusionOur OPT model is feasible from an operational point of view, but due to the limited scale of this study no conclusions can be made regarding the efficacy of the diagnostic model or outcome.
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| 2. |
- Bengtsson, Johan, et al.
(författare)
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Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy : Retrospective multicenter study with different MRI scanners
- 2023
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Background: MRI is an important tool in the prostate cancer work-up, with special emphasis on the ADC sequence. This study aimed to investigate the correlation between ADC and ADC ratio compared to tumor aggressiveness determined by a histopathological examination after radical prostatectomy.Methods: Ninety-eight patients with prostate cancer underwent MRI at five different hospitals prior to radical prostatectomy. Images were retrospectively analyzed individually by two radiologists. The ADC of the index lesion and reference tissues (contralateral normal prostatic, normal peripheral zone, and urine) was recorded. Absolute ADC and different ADC ratios were compared to tumor aggressivity according to the ISUP Gleason Grade Groups extracted from the pathology report using Spearman’s rank correlation coefficient (ρ). ROC curves were used to evaluate the ability to discriminate between ISUP 1-2 and ISUP 3-5 and intra class correlation and Bland-Altman plots for interrater reliability.Results: All patients had prostate cancer classified as ISUP grade ≥ 2. No correlation was found between ADC and ISUP grade. We found no benefit of using the ADC ratio over absolute ADC. The AUC for all metrics was close to 0.5, and no threshold could be extracted for prediction of tumor aggressivity. The interrater reliability was substantial to almost perfect for all variables analyzed.Conclusions: ADC and ADC ratio did not correlate with tumor aggressiveness defined by ISUP grade in this multicenter MRI study. The result of this study is opposite to previous research in the field.
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| 3. |
- Hashimoto, Takuya, et al.
(författare)
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The onset of star formation 250 million years after the Big Bang
- 2018
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 557:7705, s. 392-395
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Tidskriftsartikel (refereegranskat)abstract
- A fundamental quest of modern astronomy is to locate the earliest galaxies and study how they influenced the intergalactic medium a few hundred million years after the Big Bang(1-3). The abundance of star-forming galaxies is known to decline(4,5) from redshifts of about 6 to 10, but a key question is the extent of star formation at even earlier times, corresponding to the period when the first galaxies might have emerged. Here we report spectroscopic observations of MACS1149-JD1(6), a gravitationally lensed galaxy observed when the Universe was less than four per cent of its present age. We detect an emission line of doubly ionized oxygen at a redshift of 9.1096 +/- 0.0006, with an uncertainty of one standard deviation. This precisely determined redshift indicates that the red rest-frame optical colour arises from a dominant stellar component that formed about 250 million years after the Big Bang, corresponding to a redshift of about 15. Our results indicate that it may be possible to detect such early episodes of star formation in similar galaxies with future telescopes.
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| 4. |
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| 5. |
- Rydberg, Claes-Erik, et al.
(författare)
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A multiply imaged z similar to 6.3 Lyman a emitter candidate behind Abell 2261
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 467:1, s. 768-777
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Tidskriftsartikel (refereegranskat)abstract
- While the Lyman alpha (Ly alpha) emission line serves as an important tool in the study of galaxies at z less than or similar to 6, finding Ly a emitters (LAE) at significantly higher redshifts has been more challenging, probably because of the increasing neutrality of the intergalactic medium above z similar to 6. Galaxies with extremely high rest-frame Ly alpha equivalent widths, EW(Ly alpha) greater than or similar to 150 A degrees, at z > 6, are good candidates for Ly alpha follow-up observations, and can stand out in multiband imaging surveys because of their unusual colours. We have conducted a photometric search for such objects in the Cluster Lensing And Supernova survey with Hubble (CLASH), and report here the identification of three likely gravitationally lensed images of a single LAE candidate at z-6.3, behind the galaxy cluster Abell 2261 (z=0.225). In the process, we also measured with Keck/Multi-Object Spectrometer For Infra-Red Exploration the first spectroscopic redshift of a multiply imaged galaxy behind Abell 2261, at z=3.337. This allows us to calibrate the lensing model, which, in turn, is used to study the properties of the candidate LAE. Population III galaxy spectral energy distribution model fits to the CLASH broad-band photometry of the possible LAE provide a slightly better fit than Population I/II models. The best-fitting model suggests intrinsic EW(Ly alpha) approximate to 160 A degrees after absorption in the interstellar and intergalactic medium. Future spectroscopic observations will examine this prediction as well as shed more light on the morphology of this object, which indicates that it may be a merger of two smaller galaxies.
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| 6. |
- Rydberg, Claes-Erik, 1972-, et al.
(författare)
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A search for Population III galaxies in CLASH. I. Singly-imaged candidates at high redshift
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 804:1
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Tidskriftsartikel (refereegranskat)abstract
- Population III galaxies are predicted to exist at high redshifts and may be rendered sufficiently bright for detection with current telescopes when gravitationally lensed by a foreground galaxy cluster. Population III galaxies that exhibit strong Lyα emission should furthermore be identifiable from broadband photometry because of their unusual colors. Here, we report on a search for such objects at z > 6 in the imaging data from the Cluster Lensing And Supernova survey with Hubble (CLASH), covering 25 galaxy clusters in 16 filters. Our selection algorithm returns five singly-imaged candidates with Lyα-like color signatures, for which ground-based spectroscopy with current 8-10 m class telescopes should be able to test the predicted strength of the Lyα line. None of these five objects have been included in previous CLASH compilations of high-redshift galaxy candidates. However, when large grids of spectral synthesis models are applied to the study of these objects, we find that only two of these candidates are significantly better fitted by Population III models than by more mundane, low-metallicity stellar populations.
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| 7. |
- Rydberg, Claes-Erik, 1972-, et al.
(författare)
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A search for Population III galaxies in CLASH. II. A multiply-imaged candidate at z ~ 7.8 behind Abell 2261
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- While the Lyα emission line has served as an important tool in the study of galaxies at z < 6.5, Lyα emitters (LAE) have proved to be elusive at higher redshifts. If galaxies exhibiting high Lyα equivalent widths exist at z > 6.5, such rare objects may potentially stand out in multiband imaging surveys because of their unusual colors. We have conducted a search for such objects in the Cluster Lensing And Supernova survey with Hubble (CLASH) survey, and here report on the discovery of three gravitationally lensed images of a single LAE candidate behind the Abell 2261 cluster. Model fits to the CLASH broadband photometry suggests very strong Lyα emission (rest-frame Lyα equivalent width EW(Lyα) > 200 Å, prior to any IGM correction) at a redshift of z ≈ 7.8.
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| 8. |
- Rydberg, Claes-Erik, 1972-, et al.
(författare)
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Detection of isolated Population III stars with the James Webb Space Telescope
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 429:4, s. 3658-3664
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Tidskriftsartikel (refereegranskat)abstract
- The first Population III stars are predicted to form in minihaloes at z approximate to 10-30. The James Webb Space Telescope (JWST), tentatively scheduled for launch in 2018, will probably be able to detect some of the first galaxies, but whether it will also be able to detect the first stars remains more doubtful. Here, we explore the prospects of detecting an isolated Population III star or a small cluster of Population III stars down to z = 2 in either lensed or unlensed fields. Our calculations are based on realistic stellar atmospheres and take into account the potential flux contribution from the surrounding HII region. We find that unlensed Population III stars are beyond the reach of JWST, and that even lensed Population III stars will be extremely difficult to detect. However, the main problem with the latter approach is not necessarily that the lensed stars are too faint, but that their surface number densities are too low. To detect even one 60 M-circle dot Population III star when pointing JWST through the galaxy cluster MACS J0717.5+3745, the lensing cluster with the largest Einstein radius detected so far, the cosmic star formation rate of Population III stars would need to be approximately an order of magnitude higher than predicted by the most optimistic current models.
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| 9. |
- Rydberg, Claes-Erik
(författare)
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Gravitational lensing as a probe of the first stars and galaxies
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis investigates the potential for detection and identification of primordial stars, galaxies, and supernovae at high redshift.Simulations indicate that the first Population III stars should appear in minihalos of mass M = 105-106 Msol at z ≈ 10-30. To assess the detectability of these objects, theoretical models of these stars and their surrounding HII regions are used. We assess the plausibility of detection with the upcoming James Webb Space Telescope (JWST), using the gravitational lensing provided by the galaxy cluster MACSJ0717.5+3745. The conclusion is that the detection of these objects is highly improbable but not impossible.To investigate the prospects of detecting and identifying the first galaxies, the spectral synthesis code Yggdrasil is introduced. According to this code, JWST may be able to detect Population III galaxies with stellar masses as low as 105 Msol at z ≈ 10 in unlensed fields. We find that, over limited redshift intervals, it could be possible to use Hubble Space Telescope (HST) and/or JWST broadband color criteria to single out Population III galaxy candidates.The prospects of detecting gravitationally lensed Population III galaxies with JWST and HST is investigated. A lower limit to detect ≈1 Population III galaxy of ε ≈ 10-2 (HST/CLASH) and ε ≈ 10-3 (JWST using MACS J0717.5+3745 as lens) is derived, where ε is the baryon fraction converted to Population III stars in a host halo.By fitting HST/CLASH data to Yggdrasil and comparison grids, two Population III galaxy candidates are discovered. These two candidates are the first Population III galaxy candidates discovered at z > 6.5. A highly-magnified and doubly lensed extremely high-redshift (z ≈ 7.8) object is also identified.Finally the prospects of detecting core-collapse (CC) supernovae (SN) from the first galaxies at z ≈ 5-12 are investigated. The prediction is that no primordial SN is detectable, but 2-3 CC SN should be discovered by the HST/CLASH.
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| 10. |
- Schauer, Anna T. P., et al.
(författare)
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Lyman-Werner escape fractions from the first galaxies
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 467:2, s. 2288-2300
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Tidskriftsartikel (refereegranskat)abstract
- Direct collapse black holes forming in pristine, atomically cooling haloes at z approximate to 10-20 may act as the seeds of supermassive black holes (BHs) at high redshifts. In order to create a massive BH seed, the host halo needs to be prevented from forming stars. H-2 therefore needs to be irradiated by a large flux of Lyman-Werner (LW) UV photons in order to suppress H-2 cooling. A key uncertainty in this scenario is the escape fraction of LW radiation from first galaxies, which is the dominant source of UV photons at this epoch. To better constrain this escape fraction, we have performed radiation-hydrodynamical simulations of the growth of H II regions and their associated photodissociation regions in the first galaxies using the ZEUS-MP code. We find that the LWescape fraction crucially depends on the propagation of the ionization front (I-front). For an R-type I-front overrunning the halo, the LW escape fraction is always larger than 95 per cent. If the halo recombines later from the outside-in, due to a softened and weakened spectrum, the LW escape fraction in the rest frame of the halo (the near-field) drops to zero. A detailed and careful analysis is required to analyse slowly moving, D-type I-fronts, where the escape fraction depends on the microphysics and can be as small as 3 per cent in the near-field and 61 per cent in the far-field or as large as 100 per cent in both the near-field and the far-field.
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