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Sökning: WFRF:(Zahra ) > Annan publikation

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  • Bakhshi, Zeinab, 1986-, et al. (författare)
  • Storage placement in continuum computing for a robotic application
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • This paper analyzes the timing performance of a persistent storage designed for distributed containerbased architectures in industrial control applications. The storage ensures data availability andconsistency while accommodating faults. The analysis considers four aspects: 1. placement strategy,2. design options, 3. data size, and 4. evaluation under faulty conditions. Experimental results considering the timing constraints in industrial applications indicate that the storage solution can meet criticaldeadlines, particularly under specific failure patterns. Moreover, this evaluation method is applicablefor assessing other container-based critical applications with timing constraints that require persistentstorage. Further comparison results reveal that, while the method may underperform current centralized solutions under fault-free conditions, it outperforms the centralized solutions in failure scenarios
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  • Bergh, Ann-Charlotte, et al. (författare)
  • B cell receptor signaling suppressor SHP-1 is active in CLL lymph node and peripheral blood
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Protein tyrosine phosphatase SHP-1 expression and activity is downregulated or lost in several leukemias and lymphomas due to DNA promotor hypermethylation, catalytic site mutation or oxidation, or phosphorylation at inhibitory sites, implying a negative role of SHP-1 in development of leukemias/lymphomas. In chronic lymphocytic leukemia (CLL), B cell receptor (BcR) and microenvironment signal levels are important in the pathogenesis. Considering that SHP-1 is a BcR signaling suppressor, we hypothesized that SHP-1 would be down-regulated and/or inactivated in the proliferative center lymph node (LN) cells. We analyzed PTPN6 (SHP-1) gene expression, SHP-1 protein expression and phosphorylation status in matched CD5+/CD19+ peripheral blood (PB) and LN cells from 6 CLL patients, and in comparison, BcR (anti-IgM) in vitro triggered CLL PB cells from 10 patients. Gene expression of PTPN6 was significantly higher in PB compared to LN CLL cells in 50% of the cases. SHP-1 protein expression level and phosphorylation at SHP-1Y536 and SHP-1S591 were, however, equal in PB and LN samples. SHP-1 phosphorylation at Y536 and S591, in PB CLL cells cultured ex vivo was significantly reduced upon BcR engagement in all patient samples. These results indicate that in vivo BcR signaling in CLL is paralyzed.
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