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Untargeted screenin...
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis
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Zandian, A. (författare)
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Wingard, L. (författare)
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Nilsson, H. (författare)
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visa fler...
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Sjöstedt, Evelina (författare)
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Johansson, D. X. (författare)
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Just, D. (författare)
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Hellstrom, C. (författare)
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Uhlen, M. (författare)
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Schwenk, J. M. (författare)
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Haemark-Manberg, A. (författare)
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Norbeck, O. (författare)
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Owe-Larsson, B. (författare)
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Nilsson, P. (författare)
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Persson, M. A. A. (författare)
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visa färre...
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(utgivare)
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(utgivare)
- 2017
- 2017
- Engelska.
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Ingår i: Translational Psychiatry. - 2158-3188. ; 7
Abstract
Ämnesord
Stäng
- Immunological and inflammatory reactions have been suggested to have a role in the development of schizophrenia, a hypothesis that has recently been supported by genetic data. The aim of our study was to perform an unbiased search for autoantibodies in patients with a first psychotic episode, and to explore the association between any seroreactivity and the development of a Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) disorder characterized by chronic or relapsing psychotic symptoms. We collected plasma samples from 53 patients when they were treated for their first-episode psychosis, and 41 non-psychotic controls, after which the patients were followed for a mean duration of 7 years. Thirty patients were diagnosed with schizophrenia, delusional disorder, schizoaffective disorder, bipolar disorder or a long-term unspecified nonorganic psychosis during follow-up, whereas 23 patients achieved complete remission. At the end of follow-up, plasma samples were analyzed for IgG reactivity to 2304 fragments of human proteins using a multiplexed affinity proteomic technique. Eight patient samples showed autoreactivity to the N-terminal fragment of the PAGE (P antigen) protein family (PAGE2B/PAGE2/PAGE5), whereas no such autoreactivity was seen among the controls. PAGE autoreactivity was associated with a significantly increased risk of being diagnosed with schizophrenia during follow-up (odds ratio 6.7, relative risk 4.6). An immunohistochemistry analysis using antisera raised against the N-terminal fragment stained an unknown extracellular target in human cortical brain tissue. Our findings suggest that autoreactivity to the N-terminal portion of the PAGE protein family is associated with schizophrenia in a subset of patients with first-episode psychosis.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Psychiatry (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Psykiatri (hsv)
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Till lärosätets databas
- Av författaren/redakt...
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Zandian, A.
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Wingard, L.
-
Nilsson, H.
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Sjöstedt, Evelin ...
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Johansson, D. X.
-
Just, D.
-
visa fler...
-
Hellstrom, C.
-
Uhlen, M.
-
Schwenk, J. M.
-
Haemark-Manberg, ...
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Norbeck, O.
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Owe-Larsson, B.
-
Nilsson, P.
-
Persson, M. A. A ...
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visa färre...
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