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Sökning: WFRF:(Zhang Dandan)

  • Resultat 1-10 av 22
  • [1]23Nästa
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1.
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2.
  • Deng, Min, et al. (författare)
  • Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
  • 2013
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
  • Tidskriftsartikel (refereegranskat)abstract
    • To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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3.
  • Luo, Lei, et al. (författare)
  • Computational investigation of curvature effects on jet impingement heat transfer at internally cooled turbine vane leading edge regions
  • 2020
  • Ingår i: Heat Transfer Research. - : Begell House. - 1064-2285. ; 51:4, s. 333-357
  • Tidskriftsartikel (refereegranskat)abstract
    • This study is carried out by using numerical simulations to investigate the effect of target surface curvature and the nozzle-to-target surface distance on the flow structure and heat transfer characteristics in a pin-finned double-wall cooling structure. The flow is directly impinging on the target surface and is disturbed by the pin fins, and then released from the film holes after passing the double-wall chamber. The ratio between the radius of the concave outer surface and the chord length of the concave outer surface is varied from 0.500 to 1.300 and the ratio between nozzle-to-target surface distance and diameter of impingement hole is ranging from 0.5 to 2.0. The Reynolds number is between 10,000 and 50,000. Results of the flow structure in the chamber, heat transfer on the target surface, and friction factor of the pin-fi nned channel are included. It is found that an increase of the target surface curvature has signifi cant effects on the flow structure and thus the heat transfer on the target surface is augmented. The Taylor-Görtler vortices near the pin fins are also influenced by the target surface curvature. On the other hand, the nozzle-to-target surface distance influences the jet impingement and the vortices, which are generated by the curvature, remarkably. It is found that the area goodness factor and volume goodness factor are improved by the surface curvature.
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4.
  • Meng, Weida, et al. (författare)
  • Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
  • 2019
  • Ingår i: Molecular Psychiatry. - 1359-4184 .- 1476-5578.
  • Tidskriftsartikel (refereegranskat)abstract
    • Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence.
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5.
  • Adyari, Bob, et al. (författare)
  • Strong impact of micropollutants on prokaryotic communities at the horizontal but not vertical scales in a subtropical reservoir, China
  • 2020
  • Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 721
  • Tidskriftsartikel (refereegranskat)abstract
    • Micropollutants have become of great concern, because of their disrupting effects on the structure and function of microbial communities. However, little is known about the relative importance of trace micropollutants on the aquatic prokaryotic communities as compared to the traditional physico-chemical characteristics, especially at different spatial dimensions. Here, we investigated free-living (FL) and particle-associated (PA) prokaryotic communities in a subtropical water reservoir, China, across seasons at horizontal (surface water) and vertical (depth-profile) scales by using 16S rRNA gene amplicon sequencing. Our results showed that the shared variances of physico-chemicals and micropollutants explained majority of the spatial variations in prokaryotic communities, suggesting a strong joint effect of the two abiotic categories on reservoir prokaryotic communities. Micropollutants appeared to exert strong independent influence on the core sub-communities (i.e., abundant and wide-spread taxa) than on the satellite (i.e., less abundant and narrow-range taxa) counterparts. The pure effect of micropollutants on both core and satellite sub-communities from FL and PA fractions was similar to 1.5 folds greater than that of physico-chemical factors at the horizontal scale, whereas an opposite effect was observed at the vertical scale. Moreover, eight micropollutants including anti-fungal agents, antibiotics, bisphenol analogues, stimulant and UV-filter were identified as the major disrupting compounds with strong associations with core taxa of typical freshwater prokaryotes. Altogether, we concluded that the ecological disrupting effects of micropollutants on prokaryotic communities may vary along horizontal and vertical dimensions in freshwater ecosystems.
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6.
  • Andersson, Martin N, et al. (författare)
  • A sex pheromone receptor in the Hessian fly Mayetiola destructor (Diptera, Cecidomyiidae)
  • 2016
  • Ingår i: Frontiers in Cellular Neuroscience. - : Frontiers Media S. A.. - 1662-5102. ; 10:SEP2016
  • Tidskriftsartikel (refereegranskat)abstract
    • The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These features include a short, non-feeding adult life stage (1–2 days) and the use of a long-range sex pheromone produced and released by adult females. Sex pheromones are detected by members of the odorant receptor (OR) family within the Lepidoptera, but no receptors for similar long-range sex pheromones have been characterized from the Diptera. Previously, 122 OR genes have been annotated from the Hessian fly genome, with many of them showing sex-biased expression in the antennae. Here we have expressed, in HEK293 cells, five MdesORs that display male-biased expression in antennae, and we have identified MdesOR115 as a Hessian fly sex pheromone receptor. MdesOR115 responds primarily to the sex pheromone component (2S,8E,10E)-8,10-tridecadien-2-yl acetate, and secondarily to the corresponding Z,E-isomer. Certain sensory neuron membrane proteins (i.e., SNMP1) are important for responses of pheromone receptors in flies and moths. The Hessian fly genome is unusual in that it encodes six SNMP1 paralogs, of which five are expressed in antennae. We co-expressed each of the five antennal SNMP1 paralogs together with each of the five candidate sex pheromone receptors from the Hessian fly and found that they do not influence the response of MdesOR115, nor do they confer responsiveness in any of the non-responsive ORs to any of the sex pheromone components identified to date in the Hessian fly. Using Western blots, we detected protein expression of MdesOrco, all MdesSNMPs, and all MdesORs except for MdesOR113, potentially explaining the lack of response from this OR. In conclusion, we report the first functional characterization of an OR from the Cecidomyiidae, extending the role of ORs as long-range sex pheromone detectors from the Lepidoptera into the Diptera.
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7.
  • Ding, Shaozhen, et al. (författare)
  • novoPathFinder: a webserver of designing novel-pathway with integrating GEM-model
  • 2020
  • Ingår i: Nucleic Acids Research. - 0305-1048 .- 1362-4962. ; 48:W1, s. W477-W487
  • Tidskriftsartikel (refereegranskat)abstract
    • To increase the number of value-added chemicals that can be produced by metabolic engineering and synthetic biology, constructing metabolic space with novel reactions/pathways is crucial. However, with the large number of reactions that existed in the metabolic space and complicated metabolisms within hosts, identifying novel pathways linking two molecules or heterologous pathways when engineering a host to produce a target molecule is an arduous task. Hence, we built a user-friendly web server, novoPathFinder, which has several features: (i) enumerate novel pathways between two specified molecules without considering hosts; (ii) construct heterologous pathways with known or putative reactions for producing target molecule within Escherichia coli or yeast without giving precursor; (iii) estimate novel pathways with considering several categories, including enzyme promiscuity, Synthetic Complex Score (SCScore) and LD50 of intermediates, overall stoichiometric conversions, pathway length, theoretical yields and thermodynamic feasibility. According to the results, novoPathFinder is more capable to recover experimentally validated pathways when comparing other rule-based web server tools. Besides, more efficient pathways with novel reactions could also be retrieved for further experimental exploration. novoPathFinder is available at http://design.rxnfinder.org/novopathfinder/.
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8.
  • Han, Mengying, et al. (författare)
  • ChemHub: a knowledgebase of functional chemicals for synthetic biology studies
  • 2021
  • Ingår i: Bioinformatics. - 1367-4803 .- 1367-4811. ; 37:22, s. 4275-4276
  • Tidskriftsartikel (refereegranskat)abstract
    • The field of synthetic biology lacks a comprehensive knowledgebase for selecting synthetic target molecules according to their functions, economic applications and known biosynthetic pathways. We implemented ChemHub, a knowledgebase containing >90 000 chemicals and their functions, along with related biosynthesis information for these chemicals that was manually extracted from >600 000 published studies by more than 100 people over the past 10 years.
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9.
  • He, Dandan, et al. (författare)
  • Design of a Low Sidelobe Monopulse Array Antenna with Hybrid Feeding Structure
  • 2019
  • Ingår i: 2019 International Symposium on Antennas and Propagation, ISAP 2019 - Proceedings.
  • Konferensbidrag (refereegranskat)abstract
    • A low sidelobe monopulse array antenna with hybrid feeding structure is proposed. The array consists of four subarrays which employ 6 × 8 microstrip patch elements on the top layer. The feed network, which is hybrid feeding structure, is composed of 1-to-48 microstrip power dividers on the top layer, microstrip to groove gap waveguide transitions and a gap waveguide-based monopulse comparator. The microstrip unequal power dividers are compact to achieve unequal amplitude distribution. And the monopulse comparator based on groove gap waveguide has low insertion loss. Hence, the array antenna achieves low sidelobe and high efficiency. The array antenna is designed with size of 400 × 320 mm2. The simulated VSWR is less than 1.5 from 10.52 - 10.68 GHz, the simulated gain is 28.7 dBi at 10.6 GHz and the sidelobe level is less than -19 dB. The null depth in the difference pattern is less than -35 dB.
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10.
  • Luo, Lei, et al. (författare)
  • Surface temperature reduction by using dimples/protrusions in a realistic turbine blade trailing edge
  • 2018
  • Ingår i: Numerical Heat Transfer; Part A: Applications. - : Taylor & Francis. - 1040-7782. ; 74:5, s. 1265-1283
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, numerical simulations have been conducted on the heat transfer effect of dimple/protrusion layouts of a pin-finned wedge duct. Conjugate heat transfer calculations are further performed to investigate the cooling effect of modified schemes with dimples and protrusions added. Comparisons are carried out with a turbine second stage guide vane employed as the prototype. The dimple/protrusion-pin fin arrangement is set as the optimum one obtained above, and dimple depth/protrusion height varies from 0.2 to 0.3 times the structure diameter. It is found that the side-by-side arrangement and protrusion structure is more beneficial for the wedge duct endwall heat transfer. Comparison with the prototype blade shows that the addition of both dimples and protrusions are helpful in enhancing the trailing edge cooling effect. The cooling effect is increased with an increase in dimple depth/protrusion height. The results also show that the modified blade with protrusions attached at 0.3 height saves 0.48 g/s cooling mass flow and reaches the most positive performance with a 17 K, 14 K average temperature reduction, 0.022, 0.018 cooling effect increasing for pressure, suction side, respectively.
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  • Resultat 1-10 av 22
  • [1]23Nästa

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