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Träfflista för sökning "WFRF:(Zhang Futao) "

Sökning: WFRF:(Zhang Futao)

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1.
  • de Jong, Simone, et al. (författare)
  • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
  • 2018
  • Ingår i: Communications Biology. - Nature Publishing Group. - 2399-3642. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
2.
  • Guo, Futao, et al. (författare)
  • Modeling Anthropogenic Fire Occurrence in the Boreal Forest of China Using Logistic Regression and Random Forests
  • 2016
  • Ingår i: Forests. - 1999-4907. ; 7:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Frequent and intense anthropogenic fires present meaningful challenges to forest management in the boreal forest of China. Understanding the underlying drivers of human-caused fire occurrence is crucial for making effective and scientifically-based forest fire management plans. In this study, we applied logistic regression (LR) and Random Forests (RF) to identify important biophysical and anthropogenic factors that help to explain the likelihood of anthropogenic fires in the Chinese boreal forest. Results showed that the anthropogenic fires were more likely to occur at areas close to railways and were significantly influenced by forest types. In addition, distance to settlement and distance to road were identified as important predictors for anthropogenic fire occurrence. The model comparison indicated that RF had greater ability than LR to predict forest fires caused by human activity in the Chinese boreal forest. High fire risk zones in the study area were identified based on RF, where we recommend increasing allocation of fire management resources.
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3.
  • Karlsson Linnér, Richard, et al. (författare)
  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
  • 2019
  • Ingår i: Nature genetics. - 1546-1718. ; 51:2, s. 245-
  • Tidskriftsartikel (refereegranskat)abstract
    • Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (vertical bar(r) over cap (g)vertical bar similar to 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
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