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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Bäckhed, Fredrik, 1973, et al.
(författare)
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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
- 2015
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Ingår i: Cell Host & Microbe. - Cambridge : Elsevier BV. - 1931-3128 .- 1934-6069. ; 17:5, s. 690-703
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Tidskriftsartikel (refereegranskat)abstract
- The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.
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| 3. |
- Li, Dayi, et al.
(författare)
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Adaptive weighted multiscale retinex for underwater image enhancement
- 2023
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Ingår i: Engineering applications of artificial intelligence. - Amsterdam : Elsevier. - 0952-1976 .- 1873-6769. ; 123
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Tidskriftsartikel (refereegranskat)abstract
- Vision-dependent underwater vehicles are widely used in seabed resource exploration. The visual perception system of underwater vehicles relies heavily on high-quality images for its regular operation. However, underwater images taken underwater often have color distortion, blurriness, and poor contrast. To address these degradation issues, we develop an adaptive weighted multiscale retinex (AWMR) method for enhancing underwater images. To utilize the local detail features, we first divide the image into multiple sub-blocks and calculate the detail sparsity index for each one. Then, we combine the global detail sparsity index with the local detail sparsity indices to determine the optimal scale parameter and corresponding weights for each sub-block. We apply retinex processing to each sub-block using these parameters and then subject the processed sub-blocks to detail enhancement, color correction, and saturation correction. Finally, we use a gradient domain fusion method based on structure tensors to fuse the corrected and enhanced sub-blocks and obtain the final output image. Our approach improves underwater images through comparisons with current state-of-the-art (SOTA) techniques on several open-source datasets, both quality, and performance. © 2023 Elsevier Ltd
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| 4. |
- Schinke, Robert J., et al.
(författare)
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International society of sport psychology position stand : elite athlete mental health revisited
- 2024
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Ingår i: International Journal of Sport and Exercise Psychology. - Abingdon : Routledge. - 1612-197X .- 1557-251X. ; 22:4, s. 775-801
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Tidskriftsartikel (refereegranskat)abstract
- Athlete mental health, though long present within research and practice, has recently become a central topic area within the sport and exercise psychology field. The International Society of Sport Psychology has been at the forefront of these discussions, evidenced by a foundational position stand in 2018 and subsequent consensus statements derived from international think tanks. Within this position stand, contributors from the international community spanning five continents collaborated to present key, updated ideas and emerging concepts relating to clinical understandings of athlete mental health, trends in athlete mental health status, the role of the sport environment, mental health in relation to athlete careers, the global treatment of athlete mental health, cultural considerations in relation to understanding this topic, and nine synthesising postulates. © 2024 International Society of Sport Psychology.
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| 5. |
- Shen, Weixing, et al.
(författare)
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Protective effects of Wang-Bi tablet on bone destruction in collagen-induced arthritis by regulating osteoclast-osteoblast functions.
- 2019
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Ingår i: Journal of Ethnopharmacology. - : Elsevier BV. - 0378-8741 .- 1872-7573. ; 238
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Tidskriftsartikel (refereegranskat)abstract
- ETHNOPHARMACOLOGICAL RELEVANCE: Wang-bi tablet (WB) consists of 17 traditional Chinese medicines and has been used for treating rheumatoid arthritis (RA) in China for many years, however, its pharmacologic mechanism is not clear.AIM OF STUDY: The aim of this study was to investigate the therapeutic effect of WB on collagen-induced mouse arthritis and explored the underlying mechanism.MATERIALS AND METHODS: DBA/1 mice were used to establish a type II collagen-induced arthritis (CIA) model. From the day of arthritis onset, mice were treated daily by gavage with either total glucosides of paeony (TGP, 0.37 g/kg/d) or WB at a lower (1.11 g/kg/d, WBL) or higher dose of (3.33 g/kg/d, WBH) for 8 weeks. The severity of arthritis, levels of cytokines and the activation of signaling pathways were determined.RESULTS: Our results revealed that WB treatment effectively alleviated inflammatory symptoms and prevented bone erosions and joint destructions. It obviously decreased the serum concentration of pro-inflammatory cytokines TNF-α, IL-6 and IL-17α, while increased the concentration of anti-inflammatory cytokine IL-10. Interestingly, the proportion of splenic Treg cells were increased significantly. In vitro experiments showed that WB inhibited the differentiation of osteoclasts. Consistently, the mRNA levels of tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CtsK), and the activation of NF-κB and JAK-STAT3 signaling pathways in the paws of CIA mice were inhibited by WB treatment. On the other hand, up-regulation of osteogenic genes Runx2, Osterix mRNA, and activation of Wnt/β-catenin signaling pathway along with a decreased receptor activator of nuclear factor κB ligand (RANKL) expression were found in WB treated mice.CONCLUSION: Our results suggest that the therapeutic effect of Wang-bi tablet could be attributed to its inhibitory activity on NF-κB and STAT3 signaling pathway-mediated osteoclast differentiation, and its enhancement on Wnt/β-catenin signaling pathway-mediated osteoblast functions.
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| 6. |
- Chen, Jinchao, et al.
(författare)
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Global-and-Local Attention-Based Reinforcement Learning for Cooperative Behaviour Control of Multiple UAVs
- 2024
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Ingår i: IEEE Transactions on Vehicular Technology. - Piscataway : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9545 .- 1939-9359. ; 73:3, s. 4194-4206
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Tidskriftsartikel (refereegranskat)abstract
- Due to the strong adaptability and high flexibility, unmanned aerial vehicles (UAVs) have been extensively studied and widely applied in both civil and military applications. Although UAVs can achieve significant cost reduction and performance enhancement in large-scale systems by taking full advantage of their cooperation and coordination, they result in a serious cooperative behaviour control problem. Especially in dynamic environments, the cooperative behaviour control problem which has to quickly produce a safe and effective behaviour decision for each UAV to achieve group missions, is NP-hard and difficult to settle. In this work, we design a global-and-local attention-based reinforcement learning algorithm for the cooperative behaviour control problem of UAVs. First, with the motion and coordination models, we analyze the collision avoidance, motion state update, and task execution constraints of multiple UAVs, and abstract the cooperative behaviour control problem as a multi-constraint decision-making one. Then, inspired from the human-learning process where more attention is devoted to the important parts of data, we design a multi-agent reinforcement learning algorithm with a global-and-local attention mechanism to cooperatively control the behaviours of UAVs and achieve the coordination. Simulation experiments in a multi-agent particle environment provided by OpenAI are conducted to verify the effectiveness and efficiency of the proposed approach. Compared with baselines, our approach shows significant advantages in mean reward, training time, and coordination effect. © 2023 IEEE.
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| 7. |
- Hao, Meilan, et al.
(författare)
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Coarse to fine-based image–point cloud fusion network for 3D object detection
- 2024
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Ingår i: Information Fusion. - Amsterdam : Elsevier. - 1566-2535 .- 1872-6305. ; 112, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- Enhancing original LiDAR point cloud features with virtual points has gained widespread attention in multimodal information fusion. However, existing methods struggle to leverage image depth information due to the sparse nature of point clouds, hindering proper alignment with camera-derived features. We propose a novel 3D object detection method that refines virtual point clouds using a coarse-to-fine approach, incorporating a dynamic 2D Gaussian distribution for better matching and a dynamic posterior density-aware RoI network for refined feature extraction. Our method achieves an average precision (AP) of 90.02% for moderate car detection on the KITTI validation set, outperforming state-of-the-art methods. Additionally, our approach yields AP scores of 86.58% and 82.16% for moderate and hard car detection categories on the KITTI test set, respectively. These results underscore the effectiveness of our method in addressing point cloud sparsity and enhancing 3D object detection performance. The code is available at https://github.com/ZhongkangZ/LidarIG. © 2024 Elsevier B.V.
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| 8. |
- Lyu, Xinchen, et al.
(författare)
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Selective Offloading in Mobile Edge Computing for the Green Internet of Things
- 2018
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Ingår i: IEEE Network. - Piscataway : IEEE. - 0890-8044 .- 1558-156X. ; 32:1, s. 54-60
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Tidskriftsartikel (refereegranskat)abstract
- Mobile edge computing provides the radio access networks with cloud computing capabilities to fulfill the requirements of the Internet of Things services such as high reliability and low latency. Offloading services to edge servers can alleviate the storage and computing limitations and prolong the lifetimes of the IoT devices. However, offloading in MEC faces scalability problems due to the massive number of IoT devices. In this article, we present a new integration architecture of the cloud, MEC, and IoT, and propose a lightweight request and admission framework to resolve the scalability problem. Without coordination among devices, the proposed framework can be operated at the IoT devices and computing servers separately, by encapsulating latency requirements in offloading requests. Then a selective offloading scheme is designed to minimize the energy consumption of devices, where the signaling overhead can be further reduced by enabling the devices to be self-nominated or self-denied for offloading. Simulation results show that our proposed selective offloading scheme can satisfy the latency requirements of different services and reduce the energy consumption of IoT devices. © 2018 IEEE
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| 9. |
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| 10. |
- Tan, Yanhui, et al.
(författare)
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A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and inflammatory bone destruction
- 2020
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Ingår i: British Journal of Pharmacology. - : Wiley. - 0007-1188 .- 1476-5381. ; 177:18, s. 4242-4260
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Osteoclasts are unique cells to absorb bone. Targeting osteoclast differentiation is a therapeutic strategy for osteolytic diseases. Natural marine products have already become important sources of new drugs. The naturally occurring nitrobenzoyl sesquiterpenoids first identified from marine fungi in 1998 are bioactive compounds with a special structure, but their pharmacological functions are largely unknown. Here, we investigated six marine fungus-derived nitrobenzoyl sesquiterpenoids on osteoclastogenesis and elucidated the mechanisms.EXPERIMENTAL APPROACH: Compounds were first tested by RANKL-induced NF-κB luciferase activity and osteoclastic TRAP assay, followed by molecular docking to characterize the structure-activity relationship. The effects and mechanisms of the most potent nitrobenzoyl sesquiterpenoid on RANKL-induced osteoclastogenesis and bone resorption were further evaluated in vitro. Micro-CT and histology analysis were used to assess the prevention of bone destruction by nitrobenzoyl sesquiterpenoids in vivo.KEY RESULTS: Nitrobenzoyl sesquiterpenoid 4, with a nitrobenzoyl moiety at C-14 and a hydroxyl group at C-9, was the most active compound on NF-κB activity and osteoclastogenesis. Consequently, nitrobenzoyl sesquiterpenoid 4 exhibited suppression of RANKL-induced osteoclastogenesis and bone resorption from 0.5 μM. It blocked RANKL-induced IκBa phosphorylation, NF-κB p65 and RelB nuclear translocation, NFATc1 activation, reduced DC-STAMP but not c-Fos expression during osteoclastogenesis in vitro. Nitrobenzoyl sesquiterpenoid 4 also ameliorated LPS-induced osteolysis in vivo.CONCLUSION AND IMPLICATIONS: These results highlighted nitrobenzoyl sesquiterpenoid 4 as a novel inhibitor of osteoclast differentiation. This marine-derived sesquiterpenoid is a promising lead compound for the treatment of osteolytic diseases.
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