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Long-Term Outcome o...
Long-Term Outcome of Inflammatory Breast Cancer Compared to Non-Inflammatory Breast Cancer in the Setting of High-Dose Chemotherapy with Autologous Hematopoietic Cell Transplantation
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Cheng, Yee Chung (författare)
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Shi, Yushu (författare)
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Zhang, Mei-Jie (författare)
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Brazauskas, Ruta (författare)
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Hemmer, Michael T. (författare)
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Bishop, Michael R. (författare)
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Nieto, Yago (författare)
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Stadtmauer, Edward (författare)
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Ayash, Lois (författare)
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Gale, Robert Peter (författare)
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Lazarus, Hillard (författare)
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Holmberg, Leona (författare)
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Lill, Michael (författare)
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Olsson, R (författare)
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Wirk, Baldeep Mona (författare)
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Arora, Mukta (författare)
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Hari, Parameswaran (författare)
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Ueno, Naoto (författare)
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(utgivare)
- IVYSPRING INT PUBL 2017
- 2017
- Engelska.
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Ingår i: Journal of Cancer. - 1837-9664. ; 8:6, 1009-1017
Abstract
Ämnesord
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- Introduction: Inflammatory breast cancer (IBC) is a rare aggressive form of breast cancer. It is well known that the long-term survival and progression-free survival of IBC are worse than that of non-IBC. We report the long term outcomes of patients with IBC and non-IBC who had undergone high-dose chemotherapy (HDC) with autologous hematopoietic cell transplantation (AHCT). Methods: All 3387 patients with IBC or non-IBC who underwent HDC with AHCT between1990-2002 and registered with CIBMTR were included in this analysis. Transplant-related mortality (TRM), disease relapse/progression, progression-free survival (PFS) and overall survival (OS) were compared between the two cohorts. Multivariate Cox regression model was used to determine the independent impact of stage on outcomes. Results: 527 patients with IBC and 2,860 patients with non-IBC were included; the median age at transplantation (47 vs 46 years old) and median follow-up period in the 2 groups (167 vs 168 months) were similar. The most common conditioning regimen was cyclophosphamide and carboplatin based in both groups (54% in IBC and 50% in non-IBC). AHCT was well tolerated in both groups. TRM was similar in both groups (one year TRM was 2% for IBC and 3% for non-IBC, p= 0.16). The most common cause of death was disease progression or relapse (81% in IBC and 75% in non-IBC). The median survival for both IBC and non-IBC was the same at 40 months. The PFS at 10 years was 27% (95% CI: 23-31%) for IBC and 24% (95% CI: 22-26%) for non-IBC (p= 0.21), and the OS at 10 years was 31% (95% CI: 27-35%) for IBC and 28% (95% CI: 26-30%) for non-IBC (p= 0.16). In univariate analysis, patients with stage III IBC and no active diseases at transplantation had lower PFS and OS than that in non-IBC. In multivariate analysis, controlling for age, disease status at AHCT, hormonal receptor status, time from HR 1.16, 95% CI: 1- 1.34, p=0.0459), worse PFS (HR: 1.17, 95% CI: 1.01-1.36, p= 0.0339) and higher risk of disease relapse/progression (HR: 1.24, 95% CI: 1.06- 1.45, p= 0.0082) as compared to stage III non-IBC. Amongst all patients a higher stage disease was associated with worse PFS, OS and disease relapse/ progression. Conclusions: Long-term outcomes of stage III IBC patients who underwent AHCT were poorer than that in non-IBC patients confirming that the poor prognosis of IBC even in the setting of HDC with AHCT.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
Nyckelord
- Inflammatory Breast Cancer
- Hematopoietic Cell Transplantation
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Till lärosätets databas
- Av författaren/redakt...
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Cheng, Yee Chung
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Shi, Yushu
-
Zhang, Mei-Jie
-
Brazauskas, Ruta
-
Hemmer, Michael ...
-
Bishop, Michael ...
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visa fler...
-
Nieto, Yago
-
Stadtmauer, Edwa ...
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Ayash, Lois
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Gale, Robert Pet ...
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Lazarus, Hillard
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Holmberg, Leona
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Lill, Michael
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Olsson, R
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Wirk, Baldeep Mo ...
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Arora, Mukta
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Hari, Parameswar ...
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Ueno, Naoto
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visa färre...
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