| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 3. |
- Chen, Zhen, et al.
(författare)
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Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton
- 2019
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 62:7, s. 3336-3353
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Tidskriftsartikel (refereegranskat)abstract
- Monoacylglycerol lipase (MAGL) is a senile hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathological conditions, including chronic pain, inflammation, cancer, and neurodegeneration. Herein, we disclose a novel array of reversible and irreversible MAGL inhibitors by means of "tail switching" on a piperazinyl azetidine scaffold. We developed a lead irreversible-binding MAGL inhibitor 8 and reversible-binding compounds 17 and 37, which are amenable for radiolabeling with C-11 or F-18. [C-11]8 ([C-11]MAGL-2-11) exhibited high brain uptake and excellent binding specificity in the brain toward MAGL. Reversible radioligands [C-11]17 ([C-11]PAD) and [F-18]37 ([F-18]MAGL-4-11) also demonstrated excellent in vivo binding specificity toward MAGL in peripheral organs. This work may pave the way for the development of MAGL-targeted positron emission tomography tracers with tunability in reversible and irreversible binding mechanisms.
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| 4. |
- Yang, Ruiqi, et al.
(författare)
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Genomic insights revealed the environmental adaptability of Planococcus halotolerans Y50 isolated from petroleum-contaminated soil on the Qinghai-Tibet Plateau
- 2022
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Ingår i: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 823, s. 146368-
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Tidskriftsartikel (refereegranskat)abstract
- The Tibetan Plateau niche provides unprecedented opportunities to find microbes that are functional and commercial significance. The present study investigated the physiological and genomic characteristics of Pla-nococcus halotolerans Y50 that was isolated from a petroleum-contaminated soil sample from the Qinghai-Tibet Plateau, and it displayed psychrotolerant, antiradiation, and oil-degraded characteristics. Whole genome sequencing indicated that strain Y50 has a 3.52 Mb genome and 44.7% G + C content, and it possesses 3377 CDSs. The presence of a wide range of UV damage repair genes uvrX and uvsE, DNA repair genes radA and recN, superoxide dismutase, peroxiredoxin and dioxygenase genes provided the genomic basis for the adaptation of the plateau environment polluted by petroleum. Related experiments also verified that the Y50 strain could degrade n-alkanes from C-11-C-23, and approximately 30% of the total petroleum at 25 & DEG;C within 7 days. Meanwhile, strain Y50 could withstand 5 x 10(3) J/m(2) UVC and 10 KGy gamma ray radiation, and it had strong antioxidant and high radical scavengers for superoxide anion, hydroxyl radical and DPPH. In addition, pan-genome analysis and horizontal gene transfers revealed that strains with different niches have obtained various genes through hori -zontal gene transfer in the process of evolution, and the more similar their geographical locations, the more similar their members are genetically and ecologically. In conclusion, P. halotolerans Y50 possesses high potential of applications in the bioremediation of alpine hydrocarbons contaminated environment.
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| 5. |
- Xu, Guobao, et al.
(författare)
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Tree ring O-18's indication of a shift to a wetter climate since the 1880s in the western Tianshan Mountains of northwestern China
- 2015
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 120:13, s. 6409-6425
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Tidskriftsartikel (refereegranskat)abstract
- Central Asian droughts have drastically and significantly affected agriculture and water resource management in these arid and semiarid areas. Based on tree ring O-18 from native, dominant Schrenk spruce (Picea schrenkiana Fisch. et Mey.), we developed a 300year (1710-2010) standard precipitation-evaporation index (SPEI) reconstruction from January to August for China's western Tianshan Mountains. The regression model explained 37.6% of the variation in the SPEI reconstruction during the calibration period from 1950 to 2010. Comparison with previous drought reconstructions confirmed the robustness of our reconstruction. The 20th century has been a relatively wet period during the past 300years. The SPEI showed quasi 2, 5, and 10year cycles. Several pluvials and droughts with covariability over large areas were revealed clearly in the reconstruction. The two longest pluvials (lasting for 12years), separated by 50years, appeared in the 1900s and the 1960s. The most severe drought occurred from 1739 to 1761 and from 1886 to 1911 was the wettest period since 1710. Compared to previous investigations of hydroclimatic changes in the western Tianshan Mountains, our reconstruction revealed more low-frequency variability and indicated that climate in the western Tianshan Mountains shifted from dry to wet in 1886. This regime shift was generally consistent with other moisture reconstructions for the northeastern Tibetan Plateau and northern Pakistan and may have resulted from a strengthened westerly circulation. The opposite hydrological trends in the western Tianshan Mountains and southeastern Tibetan Plateau reveal a substantial influence of strengthened westerlies and weakening of the Indian summer monsoon.
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| 6. |
- Hoshino, Ayuko, et al.
(författare)
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Tumour exosome integrins determine organotropic metastasis
- 2015
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 527:7578, s. 329-
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Tidskriftsartikel (refereegranskat)abstract
- Ever since Stephen Pagets 1889 hypothesis, metastatic organotropism has remained one of cancers greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver-and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins alpha(6)beta(4) and alpha(6)beta(1) were associated with lung metastasis, while exosomal integrin alpha(v)beta(5) was linked to liver metastasis. Targeting the integrins alpha(6)beta(4) and alpha(v)beta(5) decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.
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| 7. |
- Nabizadeh, Armin, et al.
(författare)
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Spectral evolution of X-ray pulsar 4U 1901+03 during the 2019 outburst based on Insight-HXMT and NuSTAR observations
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 652
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Tidskriftsartikel (refereegranskat)abstract
- We report on a detailed spectral analysis of emission from X-ray pulsar 4U 1901+03 using data obtained by the Insight-HXMT and NuSTAR observatories during the 2019 outburst of the source. Thanks to the extensive coverage of the outburst by Insight-HXMT, we were able to investigate the spectral evolution of the source as a function of flux, and compare these results to the previous reports, focusing on the properties of a putative absorption feature at around 10 keV. In particular, we demonstrate that the broadband X-ray continuum of 4U 1901+03 can be well described with a two-component continuum model without an absorption line at 10 keV, which casts doubt on its interpretation as a cyclotron line. The high quality of the data also allowed us to perform both phase-averaged and phase-resolved spectral analyses as a function of luminosity. Finally, we performed a detailed investigation of another absorption feature in the spectrum of the source around 30 keV recently reported in the NuSTAR data. We show that this feature appears to be significantly detected both in phase-averaged and phase-resolved spectra irrespective of the continuum model.
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| 8. |
- Du, Shixiong, et al.
(författare)
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Evaluating the potential benefits of float solar photovoltaics through the water footprint recovery period
- 2024
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Ingår i: Journal of Cleaner Production. - 0959-6526. ; 446
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Tidskriftsartikel (refereegranskat)abstract
- In the context of higher demands on the development of clean energy technologies due to the issue of water shortage in China and the implementation of the 2060 carbon-neutral objective, floating photovoltaic (FPV) systems present novel opportunities for transforming the energy structure through land conservation and enhancement of power generation efficiency compared to conventional solar systems. However, there is currently a lack of comprehensive analysis on the potential benefits of FPV. Utilizing reservoir databases and employing a professional FPV system design, a methodology for determining the water footprint recovery period was introduced, which enables the assessment of potential FPV benefits. The water footprint recovery period for constructing FPV on 909 reservoirs in China was found that ranges from 1.86 yr to 10.48 yr. It is found that reservoir evaporation, latitude, and climate are closely related to the water footprint recovery period of FPV. Furthermore, by implementing FPV panels with an optimal tilt angle, covering 30% of the area in each reservoir, the annual electricity generation can amount to 1429.19 TWh, leading to savings of 5.76 billion m3 of water. This achievement corresponds to 19.41% of the national electricity consumption and a 6.86% reduction in the national residential water consumption in 2020. The overall economic benefit is 5.61 myriads RMB, equivalent to 5.76% of the national GDP. These benefits are unevenly distributed and mainly concentrated in areas with more reservoirs. The anticipated enhancement of FPV system benefits is foreseen with the ongoing development and implementation of future reservoir power infrastructure and energy storage technology. These results demonstrate the significant potential of installing FPV systems on the reservoirs in China. This study proposes a method to comprehensively evaluate the comprehensive benefits of constructing FPV in China and conduct a thorough analysis of the feasibility of FPV, which could provide reference for the development of regional industries and the achievement of sustainable development goals (SDGs).
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| 9. |
- Du, Shixiong, et al.
(författare)
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Projection of Precipitation Extremes and Flood Risk in the China–Pakistan Economic Corridor
- 2022
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media SA. - 2296-665X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- It is reported that the China–Pakistan Economic Corridor has been affected by extreme precipitation events. Since the 20th century, extreme weather events have occurred frequently, and the damage and loss caused by them have increased. In particular, the flood disaster caused by excessive extreme precipitation seriously hindered the development of the human society. Based on CRiteria Importance Through Intercriteria Correlation and square root of generalized cross-validation, this study used intensity–area–duration to analyze the trend of future extreme precipitation events, corrected the equidistance cumulative distribution function method deviation of different future scenario models (CESM2, CNRM-CM6-1, IPSL-CM6A-LR, and MIROC6) and evaluated the simulation ability of the revised model. The results showed that: 1) the deviation correction results of CNRM-CM6-1 in the Coupled Model Intercomparison Project Phase (CMIP) 6 could better simulate the precipitation data in the study area, and its single result could achieve the fitting effect of the CMIP5 multimodel ensemble average; 2) under CNRM-CM6-1, the frequency of extreme precipitation events under the three climate scenarios (SSP1-2.6, SSP3-7.0, and SSP5-8.5) presents interdecadal fluctuations of 3.215 times/10A, 1.215 times/10A, and 5.063 times/10A, respectively. The average impact area of extreme precipitation events would decrease in the next 30 years, while the total impact area and the extreme precipitation events in a small range would increase. Under the future scenario, the increase rate of extreme precipitation was highest in August, which increased the probability of extreme events; 3) in the next 30 years, the flood risk had an obvious expansion trend, which was mainly reflected in the expansion of the area of high-, medium-, and low-risk areas. The risk zoning results obtained by the two different flood risk assessment methods were different, but the overall risk trend was the same. This study provided more advanced research for regional flood risk, reasonable prediction for flood risk under future climate models, and useful information for flood disaster prediction in the study area and contributes to the formulation of local disaster prevention and reduction policies.
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| 10. |
- Liu, Peiji, et al.
(författare)
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A generalized method for the inherent energy performance modeling of machine tools
- 2021
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 61, s. 406-422
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Tidskriftsartikel (refereegranskat)abstract
- Machine tools (MTs), as the key equipment of manufacturing systems, have enormous quantities and consume a great amount of energy. However, the diversity of both machines and their energy consumption properties make it difficult to transfer the energy-saving knowledge and services among different MT. To facilitate the initialization configuration of energy-saving services, the inherent energy performance (IEP) is investigated to describe the differences in energy consumption among MTs, and a generalized method for modeling the IEP of MT and its electrical subsystems is proposed. Three key enablers, including generalized experimental design rules, automatic coding, and data processing algorithms, are presented and integrated into a supporting system to reduce the modeling efforts and knowledge requirements. Case studies of an offline manufacturing scenario and an Internet of Things (IoT)-enabled manufacturing scenario were carried out to verify the effectiveness and convenience of the proposed method. The results show that the proposed method can provide essential modeling support for large-scale energy-saving service configurations and energy-efficient MT development.
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