SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Zhang WH) "

Sökning: WFRF:(Zhang WH)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Tidskriftsartikel (refereegranskat)
  •  
2.
  • Tidskriftsartikel (refereegranskat)
  •  
3.
  • Tidskriftsartikel (refereegranskat)
  •  
4.
  •  
5.
  • Forskningsöversikt (refereegranskat)
  •  
6.
  • Tidskriftsartikel (refereegranskat)
  •  
7.
  • Mahajan, Anubha, et al. (författare)
  • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
  • 2014
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718 .- 1061-4036. ; 46:3, s. 234-234
  • Tidskriftsartikel (refereegranskat)abstract
    • To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
  •  
8.
  •  
9.
  • de Jong, Simone, et al. (författare)
  • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
  • 2018
  • Ingår i: Communications Biology. - : Nature Publishing Group. - 2399-3642. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
  •  
10.
  • Ehret, Georg B., et al. (författare)
  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
  • 2011
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 478:7367, s. 103-109
  • Tidskriftsartikel (refereegranskat)abstract
    • Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (116)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (112)
övrigt vetenskapligt (5)
Författare/redaktör
Chambers, John C. (46)
Boehnke, M (43)
Kooner, Jaspal S. (43)
Wareham, Nicholas J (40)
Metspalu, A (40)
Loos, Ruth J F (40)
visa fler...
Gudnason, V (39)
Lehtimaki, T (38)
Salomaa, V (38)
Hayward, C. (38)
Wareham, NJ (37)
Uitterlinden, Andre ... (37)
Loos, RJF (37)
Esko, T (37)
Vollenweider, P (37)
Jackson, Anne U. (36)
Peters, A (35)
Hamsten, A (35)
Laakso, M (35)
Gieger, C (35)
Zhang, Weihua (35)
Van Duijn, Cornelia ... (34)
Uitterlinden, AG (34)
Wilson, James F. (34)
Harris, Tamara B (34)
Hofman, A (33)
Boehnke, Michael (33)
Rudan, I. (33)
Zhao, JH (33)
Boerwinkle, E (33)
Langenberg, C. (32)
Samani, Nilesh J. (32)
Samani, NJ (32)
Harris, TB (32)
Esko, Tonu (32)
Elliott, P (31)
Chasman, Daniel I. (31)
Mohlke, Karen L (31)
Watkins, H (31)
van Duijn, CM (30)
Ridker, Paul M. (30)
Scott, Robert A (30)
Tuomilehto, J. (30)
Campbell, H (30)
Kuusisto, J. (30)
Metspalu, Andres (30)
van der Harst, P. (30)
Snieder, H. (30)
Hayward, Caroline (30)
Feitosa, Mary F. (30)
visa färre...
Lärosäte
Karolinska Institutet (83)
Lunds universitet (27)
Göteborgs universitet (21)
Umeå universitet (20)
Uppsala universitet (19)
Stockholms universitet (3)
visa fler...
Högskolan Dalarna (3)
Örebro universitet (1)
Linköpings universitet (1)
Mittuniversitetet (1)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (117)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (55)
Naturvetenskap (7)
Samhällsvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy