3. |
- Zhao, Zhen, et al.
(författare)
-
Establishment and Dysfunction of the Blood-Brain Barrier
- 2015
-
Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 163:5, s. 1064-1078
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.
|
|