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Träfflista för sökning "WFRF:(Zhu Kun) "

Sökning: WFRF:(Zhu Kun)

  • Resultat 1-10 av 59
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1.
  • Birney, Ewan, et al. (författare)
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
  • 2007
  • Ingår i: Nature. - 1476-4687. ; 447:7146, s. 799-816
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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2.
  • Birney, Ewan, et al. (författare)
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
  • 2007
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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3.
  • Zhao, Chaoyang, et al. (författare)
  • A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor
  • 2015
  • Ingår i: Current Biology. - Elsevier. - 1879-0445. ; 25:5, s. 613-620
  • Tidskriftsartikel (refereegranskat)abstract
    • Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms that these arthropods use to induce plant galls are poorly understood. We sequenced the genome of the Hessian fly (Mayetiola destructor; Diptera: Cecidomyiidae), a plant parasitic gall midge and a pest of wheat (Triticum spp.), with the aim of identifying genic modifications that contribute to its plant-parasitic lifestyle. Among several adaptive modifications, we discovered an expansive reservoir of potential effector proteins. Nearly 5% of the 20,163 predicted gene models matched putative effector gene transcripts present in the M. destructor larval salivary gland. Another 466 putative effectors were discovered among the genes that have no sequence similarities in other organisms. The largest known arthropod gene family (family SSGP-71) was also discovered within the effector reservoir. SSGP-71 proteins lack sequence homologies to other proteins, but their structures resemble both ubiquitin E3 ligases in plants and E3-ligase-mimicking effectors in plant pathogenic bacteria. SSGP-71 proteins and wheat Skp proteins interact in vivo. Mutations in different SSGP-71 genes avoid the effector-triggered immunity that is directed by the wheat resistance genes H6 and H9. Results point to effectors as the agents responsible for arthropod-induced plant gall formation.
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4.
  • Al Karim, Miftah, et al. (författare)
  • Synchrophasor-based data mining for power system fault analysis
  • 2012
  • Ingår i: Innovative Smart Grid Technologies (ISGT Europe), 2012 3rd IEEE PES International Conference and Exhibition on. - IEEE. - 978-146732597-4 ; s. 6465843
  • Konferensbidrag (refereegranskat)abstract
    • Phasor measurement units can provide high resolution and synchronized power system data, which can be effectively utilized for the implementation of data mining techniques. Data mining, based on pattern recognition algorithms can be of significant help for power system analysis, as high definition data is often complex to comprehend. In this paper three pattern recognition algorithms are applied to perform the data mining tasks. The deployment is carried out firstly for fault data classification, secondly for checking which faults are occurring more frequently and thirdly for identifying the root cause of a fault by clustering the parameters behind each scenario. For such purposes three algorithms are chosen, k-Nearest Neighbor, Naïve Bayes and the k-means Clustering.
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5.
  • Babazadeh, Davood, et al. (författare)
  • A Platform for Wide Area Monitoring and Control System ICT Analysis and Development
  • 2013
  • Ingår i: 2013 IEEE Grenoble Conference PowerTech, POWERTECH 2013. - IEEE. - 9781467356695
  • Konferensbidrag (refereegranskat)abstract
    • PMU-based Wide Area Monitoring and Control(WAMC) system is introduced to improve the monitoring ofpower grid across large geographic areas and control the gridusing more efficient and smart applications. The performance ofWAMC applications in real power system scenarios and impactof their supporting Information and Communication Technology(ICT) on the data quality can be quantified and analyzed bypseudo-real co-simulation test beds. The purpose of this study isto propose and develop a WAMC testing platform to facilitate thereal-time simulation of dynamic power grid, the ICTinfrastructure that overlays the grid and WAMS applications.The platform consists of OPNET, a powerful communicationnetwork emulator, connected to a real-time power systemsimulator through virtualized PMU device. The end pointstations such as Phasor Data Concentrator or PMU-basedapplications are also linked to the platform through OPNET’sreal-simulation gateway called SITL (System-In-The-Loop). Toassess the performance of the platform architecture, a case studyhas been performed with five PMUs which collect the data from apower model and deliver to PMU-based mode-estimationapplication over a typical communication network. In this study,the results explicitly intend to quantify the effect of networkprotocols on data delay.
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6.
  • Babazadeh, Davood, et al. (författare)
  • Real-Time Smart Grid Application Testing using OPNET SITL
  • 2012
  • Konferensbidrag (refereegranskat)abstract
    • Phasor -based Wide Area Monitoring and Control (WAMC) system promise to improve the monitoring of power grid across large geographic areas and accordingly controlling grid in more efficient and intelligent ways. In order to have confidence on the correctness, performance and reliability of applications used in WAMC system in real world scenarios, pseudo-real test beds where the requirements for the applications and their supporting Information and Communication Technology (ICT) can be quantified and analyzed. In this paper, a WAMC system testing platform is proposed to facilitate the real-time simulation of dynamic power grid, the ICT infrastructure that overlays the grid and WAMC applications. The proposed platform consists of OPNET as a powerful communication network simulator connected to real-time power system simulator on one side through virtualized Phasor Measurement Unit device, and linked to end point stations such as Phasor Data Concentrator or application on the other side through OPNET’s real-simulation gateway. A set of proof of concept scenarios using this framework is presented.
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7.
  • Björkman, Gunnar, et al. (författare)
  • SCADA system architectures
  • 2010
  • Annan publikation (övrigt vetenskapligt)abstract
    • The aim of deliverable 2.3 in the VIKING is to catalogue architecture patterns or reference architectures, i.e. commonly deployed solutions, for SCADA systems. These patterns are represented as a set of descriptions that capture the vast majority of SCADA systems’ architecture on a high level. The patterns developed in this report focus on: - Software services in SCADA systems and software services which SCADA systems exchange data with. - Data flows among these services. - How services are placed in different security zones (network zones). The purpose of the SCADA architecture patterns is to clarify how SCADA systems are commonly designed by employing a stringent model framework. Internal in the project the SCADA patterns will be used to develop SCADA system design models that reflect some typical systems deployed in industry. These models will be used in other work packages and deliverables in the VIKING project.
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8.
  • Bottura, Riccardo, et al. (författare)
  • SITL and HLA Co-simulation Platforms : Tools for Analysis of the Integrated ICT and Electric Power System
  • 2013
  • Ingår i: 2013 IEEE EUROCON. - 9781467322300
  • Konferensbidrag (refereegranskat)abstract
    • Due to the necessity of developing analysis tools inthe integrated ICT and power system domain, this paperdescribes and compares the architecture and configuration oftwo different co-simulation approaches called SITL and HLACo-simulation platforms. We provide several details on theirimplementation and present their features by means of theresults obtained for two test cases. The paper aims at clarifyingthe type of analysis that can be effectively carried out by usingthe two different platforms. Both platforms make use of thecommunication network simulator OPNET (Optimum NetworkPerformance). One of the two platforms operates in real time, inorder to perform system-in-the-loop (SITL) simulations. Theother platform is based on the interface between OPNET and thepower network simulation environment EMTP (ElectromagneticTransient Program). The interface is based on the application ofthe High-Level Architecture (HLA) standard.
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9.
  • Chen, Hui, et al. (författare)
  • Characterization of insolubilized humic acid and its sorption behaviors
  • 2009
  • Ingår i: Environmental Geology. - Springer. - 0943-0105. ; 57:8, s. 1847-1853
  • Tidskriftsartikel (refereegranskat)abstract
    • Insolubilized humic acid (IHA) was prepared in the laboratory by heating approach. Through the comparison between the endothermic peaks, optimal heating temperature was determined to be 330A degrees C. The modified IHA then was characterized by TG-DTA, SEM, FTIR, element analysis, and nitrogen adsorption-desorption isotherms. The removal efficiency of p-nitrophenol from the aqueous solution by adsorption onto solid IHA surfaces was shown to be a function of pH, reaction temperature, and p-nitrophenol concentration. Adsorption equilibrium data satisfactorily fitted the Langmuir adsorption isotherm. Under a certain concentration range, the removal rate of p-nitrophenol at pH 3.5 could reach 24, 29, and 35 mg/g at a temperature of 25, 35, and 45 +/- 0.1A degrees C. The results suggest that IHA could play a role as a potential efficient absorbent to remove organic contaminants, e.g., utilized to purify water contaminated by organic compounds.
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10.
  • Chenine, Moustafa, et al. (författare)
  • Survey on Priorities and Communication Requirements for PMU-based Applications in the Nordic Region
  • 2009
  • Ingår i: 2009 IEEE Bucharest PowerTech : Innovative Ideas Toward the Electrical Grid of the Future. - IEEE. - 978-1-4244-2234-0 ; s. 1183-1190
  • Konferensbidrag (refereegranskat)abstract
    • Phasor based Wide Area Monitoring and Control Systems (WAMC) promise to offer more accurate and timely data on the state of the power system, thus, increasing the possibilities to manage the system at a more efficient and responsive level and apply wide area control and protection schemes. This paper presents results of a survey on communications and technical requirements for applications based on Phasor Measurement Units (PMU). The survey was carried out in the Nordic Region with participants from Transmission System Operators (TSOs) and researchers. The survey focused on documenting the stage of research and development among TSOs and researchers in the Nordic Region, as well as, their plans and visions for the future. This includes planned PMU deployments and prioritization of PMU based applications. Furthermore, a significant part of the survey was an elicitation of communication requirements for applications based on PMU data. In the paper, an examination of the time requirements for these applications in terms of delays and samples per second and comparison similar published specifications is provided.
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