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Sökning: WFRF:(Ziegler Johann)

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1.
  • Ahmed, Shahana, et al. (författare)
  • Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
  • 2009
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 41:5, s. 585-590
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.
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2.
  • Karlsson, MariAnne, 1956, et al. (författare)
  • D1.1. Integrated Framework. Deliverable to the MeBeSafe project
  • 2018
  • Ingår i: MeBeSafe – Measures for Behaving Safely in Traffic.
  • Rapport (övrigt vetenskapligt)abstract
    • The MeBeSafe project intends to develop, implement and validate interventions that direct road users (drivers and cyclists) towards safer behaviour in common traffic situations which carry an elevated risk. More specifically, the aim is to change habitual traffic behaviour using different nudging interventions, i.e. subconsciously pushing road users in a desired direction without being prohibitive against alternative choices of action. The project will also compare different ways of coaching and evaluate the effect of a combination of nudging and coaching. This deliverable, D1.1 Integrated Framework, describes the work completed within WP1 of the MeBeSafe project. Based on literature reviews, interviews with academic and non-academic experts, discussions and workshops, the deliverable: (i) describes the key characteristics of nudging and coaching respectively; (ii) presents a framework that integrates the two, taking into consideration (in particular) time and frequency; (iii) describes underlying theories and models of relevance for understanding road user behaviour; (iii) explains road user profiles or characteristics of relevance to consider in the design of the interventions (i.e., in WP2, WP3, and WP4), as well as the design and interpretation of the outcome of the field trials (in WP5); and (iv) presents design considerations, i.e. factors that should be observed when improving on the initial ideas and further develop the design of the nudging and coaching interventions. More detailed design guidelines must be developed as part of the work to be completed in WP2, WP3, and WP4.
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