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Sökning: WFRF:(Zouali Moncef)

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1.
  • Ohlin, Mats, et al. (författare)
  • The human antibody repertoire to infectious agents: implications for disease pathogenesis
  • 2003
  • Ingår i: Molecular Immunology. - 1872-9142. ; 40:1, s. 1-11
  • Forskningsöversikt (refereegranskat)abstract
    • Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A more thorough understanding of the interplay between these factors will eventually allow us to elucidate the underlying mechanisms of disease susceptibility following infection, and to design potent vaccines and other immunomodulating reagents.
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2.
  • Viau, Muriel, et al. (författare)
  • Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
  • 2004
  • Ingår i: Infection and Immunity. - 1098-5522. ; 72:6, s. 3515-3523
  • Tidskriftsartikel (refereegranskat)abstract
    • Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Zouali, Moncef (2)
Ohlin, Mats (1)
Björck, Lars (1)
Viau, Muriel (1)
Longo, Nancy S (1)
Lipsky, Peter E (1)
Lärosäte
Lunds universitet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

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