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Lapatinib with tras...
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial.
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Baselga, José (author)
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Bradbury, Ian (author)
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Eidtmann, Holger (author)
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Di Cosimo, Serena (author)
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de Azambuja, Evandro (author)
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Aura, Claudia (author)
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Gómez, Henry (author)
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Dinh, Phuong (author)
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Fauria, Karine (author)
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Van Dooren, Veerle (author)
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Aktan, Gursel (author)
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Goldhirsch, Aron (author)
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Chang, Tsai-Wang (author)
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Horváth, Zsolt (author)
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Coccia-Portugal, Maria (author)
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Domont, Julien (author)
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Tseng, Ling-Min (author)
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Kunz, Georg (author)
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Sohn, Joo Hyuk (author)
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Semiglazov, Vladimir (author)
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Lerzo, Guillermo (author)
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Palacova, Marketa (author)
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Probachai, Volodymyr (author)
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Pusztai, Lajos (author)
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Untch, Michael (author)
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Gelber, Richard D (author)
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Piccart-Gebhart, Martine (author)
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- Holmberg, Stig B, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Lancet. - 1474-547X. ; 379:9816, s. 633-40
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour activity in models of HER2-overexpressing breast cancer. We argue that the two anti-HER2 agents given together would be better than single-agent therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Administration
- Oral
- Adult
- Aged
- Antibodies
- Monoclonal
- Humanized
- administration & dosage
- adverse effects
- Antineoplastic Combined Chemotherapy Protocols
- adverse effects
- therapeutic use
- Breast Neoplasms
- chemistry
- drug therapy
- pathology
- surgery
- Chemotherapy
- Adjuvant
- Diarrhea
- chemically induced
- Drug Administration Schedule
- Female
- Humans
- Infusions
- Intravenous
- Liver
- drug effects
- metabolism
- Middle Aged
- Neoadjuvant Therapy
- methods
- Paclitaxel
- administration & dosage
- adverse effects
- Quinazolines
- administration & dosage
- adverse effects
- Receptor
- erbB-2
- analysis
- antagonists & inhibitors
- Treatment Outcome
- Tumor Markers
- Biological
- analysis
- antagonists & inhibitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Baselga, José
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Bradbury, Ian
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Eidtmann, Holger
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Di Cosimo, Seren ...
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de Azambuja, Eva ...
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Aura, Claudia
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show more...
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Gómez, Henry
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Dinh, Phuong
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Fauria, Karine
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Van Dooren, Veer ...
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Aktan, Gursel
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Goldhirsch, Aron
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Chang, Tsai-Wang
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Horváth, Zsolt
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Coccia-Portugal, ...
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Domont, Julien
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Tseng, Ling-Min
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Kunz, Georg
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Sohn, Joo Hyuk
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Semiglazov, Vlad ...
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Lerzo, Guillermo
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Palacova, Market ...
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Probachai, Volod ...
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Pusztai, Lajos
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Untch, Michael
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Gelber, Richard ...
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Piccart-Gebhart, ...
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Holmberg, Stig B ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Lancet
- By the university
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University of Gothenburg