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  • Bowman, E. M. L., et al. (författare)
  • Advancing specificity in delirium: The delirium subtyping initiative
  • 2023
  • Ingår i: Alzheimers & Dementia. - 1552-5260.
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUNDDelirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. METHODSThe Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts. RESULTSMeeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. DISCUSSIONThe DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. HighlightsDelirium features must be clearly defined, standardized, and operationalized.Large datasets incorporating both clinical and biomarker variables should be analyzed together.Delirium screening should incorporate communication and reasoning.
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  • Pinches, S. D., et al. (författare)
  • Implementation of plasma simulators and plasma reconstruction workflows in ITER’s Integrated Modelling & Analysis Suite (IMAS)
  • 2017
  • Ingår i: 44th EPS Conference on Plasma Physics, EPS 2017. - : European Physical Society (EPS).
  • Konferensbidrag (refereegranskat)abstract
    • IMAS has been installed within the majority of the ITER Members and is being used to support ITPA activities including code benchmarking and validation. Sophisticated workflows, such as Plasma Simulators and those describing H&CD systems, have been adapted to IMAS and applied to ITER scenarios. The framework is considered sufficiently flexible to handle all foreseen approaches to the integrated (probabilistic) determination of measurement parameters (and their errors). The inclusion of UDA within the IMAS data Access Layer has allowed the fetching of IDSs directly from experimental databases and the demonstration of the first plasma reconstruction chain. An interactive Live Display in which signals are selected through a web interface has also been demonstrated. 
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  • Resultat 1-4 av 4

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