Search: WFRF:(van Deurzen Carolien H. M.)
> Broeks Annegien >
Breast cancer genom...
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
-
- Smid, Marcel (author)
- Erasmus University Rotterdam
-
- Rodríguez-González, F Germán (author)
- Erasmus University Rotterdam
-
- Sieuwerts, Anieta M (author)
- Erasmus University Rotterdam
-
show more...
-
- Salgado, Roberto (author)
- Université Libre de Bruxelles (ULB)
-
- Prager-Van der Smissen, Wendy J C (author)
- Erasmus University Rotterdam
-
- Vlugt-Daane, Michelle van der (author)
- Erasmus University Rotterdam
-
- van Galen, Anne (author)
- Erasmus University Rotterdam
-
- Nik-Zainal, Serena (author)
- Wellcome Trust Sanger Institute
-
- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Brinkman, Arie B (author)
- Radboud University Nijmegen
-
- van de Vijver, Marc J (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
- Richardson, Andrea L (author)
- Brigham and Women's Hospital / Harvard Medical School
-
- Fatima, Aquila (author)
- Erasmus University Rotterdam
-
- Berentsen, Kim (author)
- Radboud University Nijmegen
-
- Butler, Adam (author)
- Wellcome Trust Sanger Institute
-
- Martin, Sancha (author)
- Wellcome Trust Sanger Institute
-
- Davies, Helen R (author)
- Wellcome Trust Sanger Institute
-
- Debets, Reno (author)
- Erasmus University Rotterdam
-
- Gelder, Marion E Meijer-Van (author)
- Erasmus University Rotterdam
-
- van Deurzen, Carolien H M (author)
- Erasmus University Rotterdam
-
- MacGrogan, Gaëtan (author)
- Institut Bergoníe
-
- Van den Eynden, Gert G G M (author)
- University of Antwerp
-
- Purdie, Colin (author)
- Ninewells Hospital and Medical School
-
- Thompson, Alastair M (author)
- Ninewells Hospital and Medical School
-
- Caldas, Carlos (author)
- University of Cambridge
-
- Span, Paul N (author)
- Radboud University Nijmegen
-
- Simpson, Peter T (author)
- University of Queensland
-
- Lakhani, Sunil R (author)
- University of Queensland
-
- Van Laere, Steven (author)
- University of Antwerp
-
- Desmedt, Christine (author)
- Université Libre de Bruxelles (ULB)
-
- Ringnér, Markus (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Tommasi, Stefania (author)
- Istituto Tumori 'Giovanni Paolo II'
-
- Eyford, Jorunn (author)
- University of Iceland
-
- Broeks, Annegien (author)
- Netherlands Cancer Institute
-
- Vincent-Salomon, Anne (author)
- Curie Institute, Paris
-
- Futreal, P Andrew (author)
- University of Texas
-
- Knappskog, Stian (author)
- University of Bergen
-
- King, Tari (author)
- Memorial Sloan-Kettering Cancer Center
-
- Thomas, Gilles (author)
- Centre Léon Bérard
-
- Viari, Alain (author)
- Centre Léon Bérard
-
- Langerød, Anita (author)
- Oslo university hospital
-
- Børresen-Dale, Anne-Lise (author)
- Oslo university hospital
-
- Birney, Ewan (author)
- European Bioinformatics Institute
-
- Stunnenberg, Hendrik G (author)
- Radboud University Nijmegen
-
- Stratton, Mike (author)
- Wellcome Trust Sanger Institute
-
- Foekens, John A (author)
- Erasmus University Rotterdam
-
- Martens, John W M (author)
- Erasmus University Rotterdam
-
show less...
-
(creator_code:org_t)
- 2016-09-26
- 2016
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased GATA3 expression in mutant GATA3 cancers suggests GATA3 is an oncogene. In luminal cases the total number of substitutions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas the number of mutations of signatures 3 and 13 associates with immune-response specific gene expression, increased numbers of tumour-infiltrating lymphocytes and better outcome. Thus, while earlier reports imply that the sheer number of somatic aberrations could trigger an immune-response, our data suggests that substitutions of a particular type are more effective in doing so than others.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Smid, Marcel
-
Rodríguez-Gonzál ...
-
Sieuwerts, Aniet ...
-
Salgado, Roberto
-
Prager-Van der S ...
-
Vlugt-Daane, Mic ...
-
show more...
-
van Galen, Anne
-
Nik-Zainal, Sere ...
-
Staaf, Johan
-
Brinkman, Arie B
-
van de Vijver, M ...
-
Richardson, Andr ...
-
Fatima, Aquila
-
Berentsen, Kim
-
Butler, Adam
-
Martin, Sancha
-
Davies, Helen R
-
Debets, Reno
-
Gelder, Marion E ...
-
van Deurzen, Car ...
-
MacGrogan, Gaëta ...
-
Van den Eynden, ...
-
Purdie, Colin
-
Thompson, Alasta ...
-
Caldas, Carlos
-
Span, Paul N
-
Simpson, Peter T
-
Lakhani, Sunil R
-
Van Laere, Steve ...
-
Desmedt, Christi ...
-
Ringnér, Markus
-
Tommasi, Stefani ...
-
Eyford, Jorunn
-
Broeks, Annegien
-
Vincent-Salomon, ...
-
Futreal, P Andre ...
-
Knappskog, Stian
-
King, Tari
-
Thomas, Gilles
-
Viari, Alain
-
Langerød, Anita
-
Børresen-Dale, A ...
-
Birney, Ewan
-
Stunnenberg, Hen ...
-
Stratton, Mike
-
Foekens, John A
-
Martens, John W ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Lund University