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  • Hein, Z, et al. (författare)
  • Peptide-independent stabilization of MHC class I molecules breaches cellular quality control
  • 2014
  • Ingår i: Journal of cell science. - : The Company of Biologists. - 1477-9137 .- 0021-9533. ; 127:13Pt 13, s. 2885-2897
  • Tidskriftsartikel (refereegranskat)abstract
    • The intracellular trafficking of major histocompatibility complex class I (MHC-I) proteins is directed by three quality control mechanisms that test for their structural integrity, which is correlated to the binding of high-affinity antigenic peptide ligands. To investigate which molecular features of MHC-I these quality control mechanisms detect, we have followed the hypothesis that suboptimally loaded MHC-I are characterized by their conformational mobility in the F pocket region of the peptide binding site. We have created a novel variant of an MHC-I protein, Kb-Y84C, in which two alpha helices in this region are linked by a disulfide bond that mimics the conformational and dynamic effects of bound high-affinity peptide. Kb-Y84C shows a remarkable increase in the binding affinity to its light chain, β2m, and bypasses all three cellular quality control steps. Our data demonstrate that coupling between peptide and β2m binding to the MHC-I heavy chain is mediated by conformational dynamics, that support of the folded conformation of MHC-I by β2m plays a decisive role in passing the ER to cell surface transport quality controls, and that β2m association is also tested by the cell surface quality control that leads to MHC-I endocytosis.
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