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Träfflista för sökning "WFRF:(van Moorselaar Jeroen) "

Sökning: WFRF:(van Moorselaar Jeroen)

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1.
  • Artibani, Walter, et al. (författare)
  • EAU Policy on Live Surgery Events.
  • 2014
  • Ingår i: European Urology. - : Elsevier. - 1873-7560. ; 66:1, s. 87-97
  • Forskningsöversikt (refereegranskat)abstract
    • Live surgery is an important part of surgical education, with an increase in the number of live surgery events (LSEs) at meetings despite controversy about their real educational value, risks to patient safety, and conflicts of interest.
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2.
  • Bijnsdorp, Irene V., et al. (författare)
  • miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110
  • 2016
  • Ingår i: OncoTarget. - 1949-2553 .- 1949-2553. ; 7:13, s. 16676-16687
  • Tidskriftsartikel (refereegranskat)abstract
    • The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. CP110 was previously described for its contribution of centrosome amplification (CA) and early development of aggressive cell behaviour. However its regulation in metastatic cells remains unclear. Here we identified miR-129-3p as a novel metastatic microRNA. CP110 was identified as its target protein. In PCa cells that have metastatic capacity, CP110 expression was repressed by miR-129-3p. High miR-129-3p expression levels increased cell invasion, while increasing CP110 levels decreased cell invasion. Overexpression of CP110 in metastatic PCa cells resulted in a decrease in the number of metastasis. In tissues of PCa patients, low CP110 and high miR-129-3p expression levels correlated with metastasis, but not with the expression of genes related to EMT. Furthermore, overexpression of CP110 in metastatic PCa cells resulted in excessive-CA (E-CA), and a change in F-actin distribution which is in agreement with their reduced metastatic capacity. Our data demonstrate that miR-129-3p functions as a CA gatekeeper in metastatic PCa cells by maintaining pro-metastatic centrosome amplification (CA) and preventing anti-metastatic E-CA.
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3.
  • Fitzpatrick, John M., et al. (författare)
  • Optimizing treatment for men with advanced prostate cancer : expert recommendations and the multidisciplinary approach
  • 2008
  • Ingår i: Critical reviews in oncology/hematology. - 1040-8428 .- 1879-0461. ; 68:Suppl.1, s. S9-S22
  • Forskningsöversikt (refereegranskat)abstract
    • A multidisciplinary panel of 20 international experts, including urologists, radiation oncologists, and medical oncologists, convened during the Advanced Prostate Cancer Multidisciplinary Team meeting in Rome, Italy, in January 2007, to discuss the multidisciplinary team approach and current patterns of care for patients with hormone-refractory prostate cancer (HRPC). During the meeting, the experts discussed several definitions currently used in prostate cancer management, including those for senior adult patients. In addition, the panel reviewed a series of patient case studies in order to provide feedback on current treatment practices and to identify possible strategies for best practice. It was stressed that treatment decisions for senior adult patients should not be based solely on patient age. Additionally, although historically treatment decisions for advanced prostate cancer have focused on palliative care, given the survival benefit associated with docetaxel-based chemotherapy across patient subgroups, more men are likely to be offered chemotherapy for advanced-stage disease in the future.
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