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Feasibility, precis...
Feasibility, precision and validity of a novel fully automated quantitative method developed for measurement of digital joint space width in inflammatory arthritis
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- Kälvesten, Johan (författare)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Sectra AB, Linköping, Sweden
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- Haugeberg, Glenn (författare)
- Department of Neurosciences, Norwegian University of Science and Technology, Trondheim / Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway
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- Forslind, Kristina (författare)
- Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund / Section of Rheumatology, Department of Medicine, Helsingborg’s Lasarett, Helsingborg, Sweden
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- Rezaei, Hamed (författare)
- Unit of Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm / Rheumatology Clinic, Karolinska University Hospital, Stockholm, Sweden
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- Ronald F, van Vollenhoven (författare)
- Unit of Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm / Rheumatology Clinic, Karolinska University Hospital, Stockholm, Sweden
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- ObjectivesIn rheumatoid arthritis (RA) radiographic joint damage is a key long-term outcome and is often evaluated in clinical trials through the van der Heijde modified Sharp method which includes the joint space narrowing (JSN) score. The aim of this study was to investigate the feasibility, the precision and the validity of a novel fully automated method for quantifying joint space width (JSW) in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in order to develop a method for use in the clinic where manual scoring is usually not available.MethodsRadiographs from the SWEFOT trial were examined and processed for automated quantification of 1 year change (1yCh) in average JSW in MCP joints 2, 3 and 4 and proximal PIP joints 2 and 3. The relationship between change in JSW and change in JSN was studied using linear regression.Results1yCh in MCP234 and PIP23 was successfully measured in 119/119 and 117/119 patients respectively. Reproducibility expressed as coefficient of variation was 1.4% for MCP234 JSW and 1.6% for PIP23 JSW. There was a significant relationship between 1yCh in MCP234 JSW and 1yCh in JSN (r= -0.19, p=0.036). In contrast, 1yCh in PIP23 JSW was not independently significantly associated with 1yCh in JSN.Conclusion Automated measurement of change in MCP234 JSW was technically feasible and it was related to the change in JSN. Adding PIP23 JSW did not strengthen the association to JSN. We are continuing to study the possible utility of JSW in clinical trials and clinical practice.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Joint space width
- rheumatoid arthritis
- Computer-aided joint space analysis
- Sharp van der Heijde score
- Digital X-ray radiogrammetry
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