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Sökning: WFRF:(Öhrfelt Annika 1973 ) > (2015-2019) > (2015)

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1.
  • Brinkmalm-Westman, Ann, 1966-, et al. (författare)
  • Explorative and targeted neuroproteomics in Alzheimer's disease.
  • 2015
  • Ingår i: Biochimica et biophysica acta. - 0006-3002. ; 1854:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Alzheimer's disease (AD) is a progressive brain amyloidosis that injures brain regions involved in memory consolidation and other higher brain functions. Neuropathologically, the disease is characterized by accumulation of a 42 amino acid peptide called amyloid β (Aβ42) in extracellular senile plaques, intraneuronal inclusions of hyperphosphorylated tau protein in neurofibrillary tangles, and neuronal and axonal degeneration and loss. Biomarker assays capturing these pathologies have been developed for use on cerebrospinal fluid samples but there are additional molecular pathways that most likely contribute to the neurodegeneration and full clinical expression of AD. One way of learning more about AD pathogenesis is to identify novel biomarkers for these pathways and examine them in longitudinal studies of patients in different stages of the disease. Here, we discuss targeted proteomic approaches to study AD and AD-related pathologies in closer detail and explorative approaches to discover novel pathways that may contribute to the disease. This article is part of a Special Issue entitled: Neuroproteomics: Applications in neuroscience and neurology.
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2.
  • Bäckström, David C, et al. (författare)
  • Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease.
  • 2015
  • Ingår i: JAMA NEUROLOGY. - 2168-6149 .- 2168-6157. ; 72:10, s. 1175-1182
  • Tidskriftsartikel (refereegranskat)abstract
    • Alterations in cerebrospinal fluid (CSF) have been found in Parkinson disease (PD) and in PD dementia (PDD), but the prognostic importance of such changes is not well known. In vivo biomarkers for disease processes in PD are important for future development of disease-modifying therapies.
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3.
  • Hall, Sara, et al. (författare)
  • CSF biomarkers and clinical progression of Parkinson disease.
  • 2015
  • Ingår i: Neurology. - American Academy of Neurology. - 1526-632X. ; 84:1, s. 57-63
  • Tidskriftsartikel (refereegranskat)abstract
    • To investigate whether certain CSF biomarkers at baseline can predict future progression of motor symptoms and cognitive decline in patients with Parkinson disease (PD).
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