SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Adams Robin) "

Sökning: WFRF:(Adams Robin)

  • Resultat 1-5 av 5
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Adams, Robin, et al. (författare)
  • What is the word for 'Engineering' in Swedish : Swedish students conceptions of their discipline
  • 2007
  • Rapport (övrigt vetenskapligt)abstract
    • Engineering education in Sweden – as in the rest of the world – is experiencing a decline in student interest. There are concerns about the ways in which students think about engineering education, why they join an academic programme in engineering, and why they persist in their studies. In this context the aims of the Nationellt ämnesdidaktiskt Centrum för Teknikutbildning i Studenternas Sammanhang project (CeTUSS) is to investigate the student experience and to identify and support a continuing network of interested researchers, as well as in building capacity for disciplinary pedagogic investigation.The Stepping Stones project brings together these interests in a multi-researcher, multi-institutional study that investigates how tudents and academic staff perceive engineering in Sweden and in Swedish education. The first results of that project are reported here. As this study is situated uniquely in Swedish education, it allows for exploration of “a Swedish perspective” on conceptions of engineering. The Stepping Stones project was based on a model of research capacity-building previously instantiated in the USA and Australia (Fincher & Tenenberg, 2006).
  •  
3.
  • Bellenguez, Celine, et al. (författare)
  • Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
  • 2012
  • Ingår i: Nature Genetics. - Nature Publishing Group. - 1061-4036. ; 44:3, s. 328-U141
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.
  •  
4.
  •  
5.
  • Scott, Robert A., et al. (författare)
  • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
  • 2016
  • Ingår i: Science Translational Medicine. - 1946-6234. ; 8:341
  • Tidskriftsartikel (refereegranskat)abstract
    • Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and follow-up in 39,979 individuals by targeted genotyping, with additional in silico follow-up in consortia. We used these data to first compare associations of variants in genes encoding drug targets with the effects of pharmacological manipulation of those targets in clinical trials. We then tested the association of those variants with disease outcomes, including coronary heart disease, to predict cardiovascular safety of these agents. A low-frequency missense variant (Ala316Thr; rs10305492) in the gene encoding glucagon-like peptide-1 receptor (GLP1R), the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP1R agonist therapies. The minor allele was also associated with protection against heart disease, thus providing evidence that GLP1R agonists are not likely to be associated with an unacceptable increase in cardiovascular risk. Our results provide an encouraging signal that these agents may be associated with benefit, a question currently being addressed in randomized controlled trials. Genetic variants associated with metabolic traits and multiple disease outcomes can be used to validate therapeutic targets at an early stage in the drug development process.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-5 av 5
Typ av publikation
tidskriftsartikel (3)
konferensbidrag (1)
rapport (1)
Typ av innehåll
refereegranskat (4)
övrigt vetenskapligt (1)
Författare/redaktör
Adams, Robin (2)
Fincher, Sally (2)
Deloukas, Panos (2)
Kaaks, Rudolf (1)
Boeing, Heiner (1)
Tumino, Rosario (1)
visa fler...
Sacerdote, Carlotta (1)
Barricarte, Aurelio (1)
Key, Timothy J (1)
Riboli, Elio (1)
Franks, Paul W, (1)
Rolandsson, Olov, (1)
Rothwell, Peter M. (1)
Kittner, Steven J. (1)
Adams, Christopher M ... (1)
Börstler, Jürgen (1)
Lindberg, Vanja (1)
Pears, Arnold (1)
Boustedt, Jonas, (1)
Dalenius, Peter (1)
Eken, Gunilla (1)
Heyer, Tim (1)
Jacobsson, Andreas (1)
Molin, Bengt (1)
Moström, Jan-Erik (1)
Wiggberg, Mattias (1)
Bousted, J. (1)
Fischer, Sally (1)
Navarro, Carmen (1)
Wareham, Nicholas J (1)
Palli, Domenico (1)
Panico, Salvatore (1)
Norrving, Bo (1)
Rosand, Jonathan (1)
Stancáková, Alena (1)
Kuusisto, Johanna (1)
Laakso, Markku (1)
McCarthy, Mark I (1)
Chu, Audrey Y (1)
Langenberg, Claudia (1)
Grarup, Niels (1)
Linneberg, Allan (1)
Boehnke, Michael (1)
Mohlke, Karen L (1)
Pedersen, Oluf (1)
Scott, Robert A (1)
Hansen, Torben (1)
Varga, Tibor V (1)
Jorgensen, Torben (1)
Saleheen, Danish (1)
visa färre...
Lärosäte
Uppsala universitet (3)
Lunds universitet (2)
Umeå universitet (2)
Högskolan i Gävle (1)
Blekinge Tekniska Högskola (1)
Karlstads universitet (1)
Språk
Engelska (5)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
Naturvetenskap (2)
Samhällsvetenskap (2)
Teknik (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy