- Ciray, Ipek, et al.
Evaluation of new sclerotic bone metastases in breast cancer patients during treatment
Ingår i: Acta Radiologica. - 0284-1851 .- 1600-0455. ; 41:2, s. 178-182
- <p>PURPOSE:</p> <p>According to the World Health Organization (WHO) criteria for response of bone metastases to therapy, new lesions indicate progressive disease. We intended to prove that a new sclerotic lesion on conventional radiography may also be a sign of a positive therapeutic response in a previously undetectable lytic metastasis.</p> <p>MATERIAL AND METHODS:</p> <p>In a previous placebo-controlled clinical trial of clodronate (Ostac) therapy, 139 breast cancer patients with bone metastases underwent both conventional radiography and bone scan every 6 months for 2 years with 99mTc before and during clodronate treatment. WHO criteria were applied for therapy response evaluation.</p> <p>RESULTS:</p> <p>In 24 patients, 52 new sclerotic lesions observed during therapy were selected for re-evaluation of conventional radiographs and bone scans. In 8 of the 24 patients, 17 of 52 new sclerotic lesions (33%) had showed positive uptake on previous bone scans. These lesions were possibly misinterpreted as new when applying WHO criteria.</p> <p>CONCLUSION:</p> <p>For better assessment of new sclerotic lesions during treatment, more sensitive techniques, e.g. bone scan, are needed as a complement to conventional radiography.</p>