1. 
 Hall, Sara, et al.
(författare)

Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.
 2012

Ingår i: Archives of neurology.  15383687. ; 69:11, s. 144552

Tidskriftsartikel (refereegranskat)abstract
 Objective: To assess the ability of 5 cerebrospinal fluid (CSF) biomarkers to differentiate between common dementia and parkinsonian disorders. Design: A crosssectional, clinicbased study. Participants: Cerebrospinal fluid samples (N=453) were obtained from healthy individuals serving as controls and from patients with Parkinson disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), Alzheimer disease (AD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or corticobasal degeneration (CBD). Setting: Neurology and memory disorder clinics. Main Outcome Measures: Cerebrospinal fluid biomarker levels in relation to clinical diagnosis. Results: Cerebrospinal fluid levels of alphasynuclein were decreased in patients with PD, PDD, DLB, and MSA but increased in patients with AD. Cerebrospinal fluid levels of betaamyloid 142 were decreased in DLB and even further decreased in AD. Cerebrospinal fluid levels of total tau and hyperphosphorylated tau were increased in AD. Multivariate analysis revealed that these biomarkers could differentiate AD from DLB and PDD with an area under the curve of 0.90, with alphasynuclein and total tau contributing most to the model. Cerebrospinal fluid levels of neurofilament light chain were substantially increased in atypical parkinsonian disorders (ie, PSP, MSA, and CBD), and multivariate analysis revealed that the level of neurofilament light chain alone could differentiate PD from atypical parkinsonian disorders, with an area under the curve of 0.93. Conclusions: Ascertainment of the alphasynuclein level in CSF somewhat improves the differential diagnosis of AD vs DLB and PDD when combined with established AD biomarkers. The level of neurofilament light chain alone may differentiate PD from atypical parkinsonian disorders.


2. 
 Andreasson, Håkan, 1966
(författare)

Black hole formation from a complete past for the einstein–vlasov system
 2014

Ingår i: International conference on Relativity and Gravitation, 2012, Prague, Czech Republic, 2529 June 2012.  09308989 . 18674941.  9783319067605 ; 157, s. 1118

Konferensbidrag (refereegranskat)abstract
 Anatural question in general relativity is to find initial data for the Einstein equations whose past evolution is regular and whose future evolution contains a black hole. In [1] initial data of this kind is constructed for the spherically symmetric Einstein–Vlasov system. One consequence of the result is that there exists a class of initial data for which the ratio of the Hawking mass (Formula presented) (r) and the area radius r is arbitrarily small everywhere, such that a black hole forms in the evolution. This result is analogous to the result [2] for a scalar field. Another consequence is that there exist black hole initial data such that the solutions exist for all Schwarzschild time t ∈ (−∞,∞). In the present article we review the results in [1].


3. 
 Andreasson, Håkan, 1966
(författare)

Black Hole Formation from a Complete Regular Past for Collisionless Matter
 2012

Ingår i: Annales Henri Poincaré.  14240637. ; 13:7, s. 15111536

Tidskriftsartikel (refereegranskat)abstract
 Initial data for the spherically symmetric EinsteinVlasov system is constructed whose past evolution is regular and whose future evolution contains a black hole. This is the first example of initial data with these properties for the Einsteinmatter system with a "realistic" matter model. One consequence of the result is that there exists a class of initial data for which the ratio of the Hawking mass mIS= mIS (r) and the area radius r is arbitrarily small everywhere, such that a black hole forms in the evolution. This result is in a sense analogous to the result (Christodoulou Commun Pure Appl Math 44:339373, 1991) for a scalar field. Another consequence is that there exist black hole initial data such that the solutions exist for all Schwarzschild time .


4. 
 Andreasson, Håkan, 1966, et al.
(författare)

Bounds on M/R for charged objects with positive cosmological constant
 2012

Ingår i: Classical and Quantum Gravity.  02649381. ; 29:9

Tidskriftsartikel (refereegranskat)abstract
 We consider charged spherically symmetric static solutions of the EinsteinMaxwell equations with a positive cosmological constant Lambda. If r denotes the area radius, m(g) and q the gravitational mass and charge of a sphere with area radius r respectively, we find that for any solution which satisfies the condition p + 2p(perpendicular to) +/ = 0 and p(perpendicular to) are the radial and tangential pressures respectively, rho >= 0 is the energy density, and for which 0


5. 
 Andréasson, Håkan, et al.
(författare)

Cytoreductive surgery in pseudomyxoma peritoneiaspects of the learning curve
 2013

Ingår i: European Journal of Surgical Oncology.  07487983 . 15322157. ; 40:8, s. 930936

Tidskriftsartikel (refereegranskat)abstract
 Background: Cytoreductive surgery (CRS) plus perioperative intraperitoneal chemotherapy is a highly invasive treatment of peritoneal metastasis and requires many surgical procedures before mastering. The aim of this study was to estimate how many procedures are needed before stabilization can be seen in surgical outcome (R1 surgery, adverse events and bleeding) in patients with pseudomyxoma peritonei (PMP). Patients and methods: All 128 patients with PMP who were treated with CRS alone or CRS plus perioperative intraperitoneal chemotherapy between 2003 and 2008 at the Uppsala University Hospital, Uppsala, Sweden, were included. The learning curve was calculated using the partial least square (PLS) and cumulative sum control chart (CUSUM) graph. Two groups were formed based on the results of the learning curve. The learning curve plateau was considered the same as the stabilization in the CUSUM graph. Group I consisted of patients included during the learning period (n = 73) and Group 11 of patients treated after the learning period ended (n = 55). Comparisons between the groups were made on surgical outcome, survival and adverse events. Results: Stabilization was seen after 220 +/ 10 procedures. A higher occurrence of R1 surgery was seen in Group H (80%) compared to Group I (48%; P = 0.0002). Overall survival increased at four years after surgery in Group H compared to Group I (80% vs. 63%; P = 0.02). Conclusion: CRS plus perioperative intraperitoneal chemotherapy is a highly demanding procedure that requires more than 200 procedures before optimisation in surgical outcome is seen.


6. 
 Andreasson, Håkan, 1966, et al.
(författare)

Existence of axially symmetric static solutions of the EinsteinVlasov system
 2011

Ingår i: Commun. Math. Phys..  00103616. ; 308, s. 2347

Tidskriftsartikel (refereegranskat)abstract
 We prove the existence of static, asymptotically flat nonvacuum spacetimes with axial symmetry where the matter is modeled as a collisionless gas. The axially symmetric solutions of the resulting EinsteinVlasov system are obtained via the implicit function theorem by perturbing off a suitable spherically symmetric steady state of the VlasovPoisson system.


7. 
 Andreasson, Håkan, 1966, et al.
(författare)

Existence of axially symmetric static solutions of the EinsteinVlasov system
 2011

Ingår i: Communications in Mathematical Physics.  14320916 . 00103616. ; 308:1, s. 2347

Tidskriftsartikel (refereegranskat)abstract
 We prove the existence of static, asymptotically flat nonvacuum spacetimes with axial symmetry where the matter is modeled as a collisionless gas. The axially symmetric solutions of the resulting EinsteinVlasov system are obtained via the implicit function theorem by perturbing off a suitable spherically symmetric steady state of the VlasovPoisson system.


8. 
 Andreasson, Håkan, 1966, et al.
(författare)

Formation of trapped surfaces for the spherically symmetric EinsteinVlasov system
 2010

Rapport (övrigt vetenskapligt)abstract
 We consider the spherically symmetric, asymptotically flat, nonvacuum Einstein equations, using as matter model a collisionless gas as described by the Vlasov equation. We find explicit conditions on the initial data which guarantee the formation of a trapped surface in the evolution which in particular implies that weak cosmic censorship holds for these data. We also analyze the evolution of solutions after a trapped surface has formed and we show that the event horizon is future complete. Furthermore we find that the apparent horizon andthe event horizon do not coincide. This behavior is analogous to what is found in certain Vaidya spacetimes. The analysis is carried out in EddingtonFinkelstein coordinates.


9. 
 Andreasson, Håkan, 1966, et al.
(författare)

Formation of trapped surfaces for the spherically symmetric EinsteinVlasov system
 2010

Ingår i: Journal of Hyperbolic Differential Equations.  02198916. ; 7:4, s. 707731

Tidskriftsartikel (refereegranskat)abstract
 We consider the spherically symmetric, asymptotically flat, nonvacuum Einstein equations, using as matter model a collisionless gas as described by the Vlasov equation. We find explicit conditions on the initial data which guarantee the formation of a trapped surface in the evolution which in particular implies that weak cosmic censorship holds for these data. We also analyze the evolution of solutions after a trapped surface has formed and we show that the event horizon is future complete. Furthermore we find that the apparent horizon and the event horizon do not coincide. This behavior is analogous to what is found in certain Vaidya spacetimes. The analysis is carried out in EddingtonFinkelstein coordinates.


10. 

