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Sökning: WFRF:(Berglund Monica)

  • Resultat 1-10 av 27
  • [1]23Nästa
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  • Rönn, Monika, et al. (författare)
  • Bisphenol A exposure increases liver fat in juvenile fructose-fed Fischer 344 rats
  • 2013
  • Ingår i: Toxicology. - 0300-483X. ; 303:1, s. 125-132
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND:Prenatal exposure to bisphenol A (BPA) has been shown to induce obesity in rodents. To evaluate if exposure also later in life could induce obesity or liver damage we investigated these hypothesises in an experimental rat model.METHODS: From five to fifteen weeks of age, female Fischer 344 rats were exposed to BPA via drinking water (0.025, 0.25 or 2.5mgBPA/L) containing 5% fructose. Two control groups were given either water or 5% fructose solution. Individual weight of the rats was determined once a week. At termination magnetic resonance imaging was used to assess adipose tissue amount and distribution, and liver fat content. After sacrifice the left perirenal fat pad and the liver were dissected and weighed. Apolipoprotein A-I in plasma was analyzed by western blot.RESULTS:No significant effects on body weight or the weight of the dissected fad pad were seen in rats exposed to BPA, and MRI showed no differences in total or visceral adipose tissue volumes between the groups. However, MRI showed that liver fat content was significantly higher in BPA-exposed rats than in fructose controls (p=0.04). BPA exposure also increased the apolipoprotein A-I levels in plasma (p<0.0001).CONCLUSION: We found no evidence that BPA exposure affects fat mass in juvenile fructose-fed rats. However, the finding that BPA in combination with fructose induced fat infiltration in the liver at dosages close to the current tolerable daily intake (TDI) might be of concern given the widespread use of this compound in our environment.
  • Rönn, Monika, et al. (författare)
  • Quantification of total and visceral adipose tissue in fructose-fed rats using water-fat separated single echo MRI
  • 2013
  • Ingår i: Obesity. - 1930-7381. ; 21:9, s. E388-E395
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The aim of this study was to setup a rodent model for modest weight gain and an MRI-based quantification of body composition on a clinical 1.5 T MRI system for studies of obesity and environmental factors and their possible association. Design and Methods: Twenty-four 4-week-old female Fischer rats were divided into two groups: one exposed group (n=12) and one control group (n 12). The exposed group was given drinking water containing fructose (5% for 7 weeks, then 20% for 3 weeks). The control group was given tap water. Before sacrifice, whole body MRI was performed to determine volumes of total and visceral adipose tissue and lean tissue. MRI was performed using a clinical 1.5 T system and a chemical shift based technique for separation of water and fat signal from a rapid single echo acquisition. Fat signal fraction was used to separate adipose and lean tissue. Visceral adipose tissue volume was quantified using semiautomated segmentation. After sacrifice, a perirenal fat pad and the liver were dissected and weighed. Plasma proteins were analyzed by Western blot. Results: The weight gain was 5.2% greater in rats exposed to fructose than in controls (P=0.042). Total and visceral adipose tissue volumes were 5.2 cm(3) (P=0.017) and 3.1 cm(3) (P=0.019) greater, respectively, while lean tissue volumes did not differ. The level of triglycerides and apolipoprotein A-I was higher (P=0.034, P=0.005, respectively) in fructose-exposed rats.
  • Berglund, Eva, et al. (författare)
  • Communicative skills in relation to gender, birth order, childcare and socioeconomic status in 18-month-old children
  • 2005
  • Ingår i: Scandinavian Journal of Psychology. - 0036-5564. ; 46:6, s. 485-491
  • Tidskriftsartikel (refereegranskat)abstract
    • Variation in communicative skills, defined as gestures, vocabulary comprehension and vocabulary production, was examined as a function of gender, birth order, childcare and socioeconomic status (SES) in 1,019 18-month-old children. The children were recruited at their regular check-up at a number of randomly selected Child Health Care centers in a Swedish county. The participation rate was 88%. The children were assessed by their mothers using a short version of the Swedish Early Communicative Development Inventories. The results demonstrate significant effects of gender and birth order on vocabulary comprehension and vocabulary production. Girls scored higher than boys and first-born children scored higher than later-born children. Type of childcare (family care, care at home and day-care centers) interacted with gender and birth order on vocabulary production and indicated that family care is not as advantageous as care at home or at day-care centers. SES had no effect on children's communicative skills at this age.
  • Berglund, Maria, 1975-, et al. (författare)
  • Assessment of mRNA levels for matrix molecules and TGF-B1 in rabbit flexor and peroneus tendons reveals regional differences in steady-state expression
  • 2004
  • Ingår i: Journal of Hand Surgery - British and European Volume. - 0266-7681. ; 29:2, s. 165-169
  • Tidskriftsartikel (refereegranskat)abstract
    • This study analysed the differences on a molecular level between two segments of the deep flexor tendon, and compared the intrasynovial flexor tendon with the tendon sheath and the extrasynovial peroneus tendon in a rabbit model. The TRIspin method of RNA extraction was combined with the reverse transcription polymerase chain reaction to assess mRNA levels in the tissue segments. Significant differences were detected for all genes studied. mRNA levels for aggrecan, biglycan and collagen III were significantly higher in the fibrocartilaginous proximal segment of the flexor tendon. Collagen I was higher in the flexor tendon than the sheath and the peroneus tendon, and TGF-beta1 was significantly lower in the peroneus tendon. This study demonstrates differences at the mRNA level between different segments of tendon, indicating that the tendon tissue may be adapted to its environment.
  • Berglund, Maria, 1975-, et al. (författare)
  • Growth Factor and Protease Expression during Different Phases of Healing after Rabbit Deep Flexor Tendon Repair
  • 2011
  • Ingår i: Journal of Orthopaedic Research. - 0736-0266. ; 29:6, s. 886-892
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of the study was to contribute to the mapping of molecular events during flexor tendon healing, in particular the growth factors insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF) and nerve growth factor (NGF), matrix metalloproteinases (MMP-3 and MMP-13) and their inhibitors (tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-3, and the protease cathepsin K. In a rabbit model of flexor tendon injury, the mRNA expression for the growth factors, MMPs and TIMPs were measured in tendon and tendon sheath tissue at several time points (3, 6, 21, and 42 days) representing different phases of the healing process. We found that MMP-13 remained increased during the study period, whereas MMP-3 returned to normal levels within the first week after injury. TIMP-3 was down-regulated in the tendon sheaths. Cathepsin K was up-regulated in tendons and sheaths after injury. NGF was present in both tendons and sheaths, but unaltered. IGF-1 exhibited a late increase in the tendons, while VEGF was down-regulated at the later time points. In conclusion, we have demonstrated the presence of NGF in flexor tendons. MMP-13 expression appears to play a more protracted role in flexor tendon healing than MMP-3. The relatively low levels of endogenous IGF-1 and VEGF mRNA following injury support their potential beneficial role as exogenous modulators to optimize tendon healing and strength without increasing adhesion formation.
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