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Träfflista för sökning "WFRF:(Berglund Per) ;pers:(Högberg Hans Erik)"

Sökning: WFRF:(Berglund Per) > Högberg Hans Erik

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1.
  • Berglund, Per, et al. (författare)
  • 2-Methylalkanoic Acids Resolved by Esterification Catalysed by Candida rugosa : Alcohol Chain Length and Enantioselectivity
  • 1993
  • Ingår i: Tetrahedron: Asymmetry. - 0957-4166. ; 4:8, s. 1869-1878
  • Tidskriftsartikel (refereegranskat)abstract
    • Enantiomerically pure (R)-2-methyldecanoic acid and (S)-2-methyl-1-decanol were prepared in a multi gram scale by esterification reactions catalysed by lipase from Candida rugosa. The enantiomeric ratios (E-values) were determined as a function of the chain length of the alcohol used as the complementary substrate in cyclohexane. In the resolution of 2-methyldecanoic acid the highest value (E = 37 ± 5) was obtained, when either 2-hexanol, 1-heptanol or 1-octanol were used. In contrast, when resolving 2-methyloctanoic acid, the E-values increased continually with increasing chain length of the alcohol used. 1-Hexadecanol gave the highest value: E > 100. The E-values were determined from the enantiomeric excess (ee) of the product at a conversion below 0.4. After two consecutive esterification reactions enantiomerically pure (R)-2-methyldecanoic acid, >99.8% ee, and after subsequent reduction of the ester produced, (S)-2-methyl-1-decanol, 96.7% ee, were obtained.
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