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Sökning: WFRF:(Bergström Göran) > (2010-2011)

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  • Bodvik, Rasmus, et al. (författare)
  • Aggregation and network formation of aqueous methylcellulose and hydroxypropylmethylcellulose solutions.
  • 2010
  • Ingår i: Colloids and Surfaces A : Physicochemical and Engineering Aspects. - Elsevier. - 0927-7757. ; 354:1-3, s. 162-171
  • Tidskriftsartikel (refereegranskat)abstract
    • Solution properties of methylcellulose (MC) and hydroxypropylmethylcellulose (HPMC) have been investigated as a function of temperature and concentration using a broad range of experimental techniques. Novelties include the extensive comparison between MC and HPMC solutions as well as the combination of techniques, and the use of Cryo transmission electron microscopy (Cryo-TEM). The correlation between rheology and light scattering results clearly demonstrates the relation between viscosity change and aggregation. Cryo-TEM images show the network structures formed. Viscosity measurements show that for both MC and HPMC solutions sudden changes in viscosity occur as the temperature is increased. The onset temperature for these changes depends on polymer concentration and heating rate. For both MC and HPMC solutions the viscosity on cooling is very different compared to on heating, demonstrating the slow equilibration time. The viscosity changes in MC and HPMC solutions are dramatically different; for MC solutions the viscosity increases by several orders of magnitude when a critical temperature is reached, whereas for HPMC solutions the viscosity decreases abruptly at a given temperature, followed by an increase upon further heating. Light and (SAXS) small-angle X-ray scattering shows that the increase in viscosity, for MC as well as for HPMC solutions, is due to extensive aggregation of the polymers. Light scattering also provides information on aggregation kinetics. The SAXS measurements allow us to correlate aggregation hysteresis to the viscosity hysteresis, as well as to extract some structural information. Cryo-TEM images give novel information that a fibrillar network is formed in MC solutions, and the strong viscosity increase occurs when this network spans the whole solution volume. For HPMC solutions the behaviour is more complex. The decrease in viscosity can be related to the formation of compact objects, and the subsequent increase to formation of fibrillar structures, which are more linear and less entangled than for MC.
  • Andersson, Gerhard, et al. (författare)
  • Paniksyndrom : ond cirkel av feltolkade kroppsliga signaler
  • 2011
  • Ingår i: Läkartidningen. - 0023-7205. ; 108:14, s. 795-797
  • Tidskriftsartikel (refereegranskat)abstract
    • Attacker av intensiv rädsla utan tydlig yttre orsak som leder till rädsla för nya attacker – det kännetecknar paniksyndrom. Evidensbaserade behandlingsalternativ finns, och det finns inget skäl att avvakta med behandling.
  • Behre, Carl Johan, 1968-, et al. (författare)
  • Increasing Leisure Time Physical Activity is Associated With Less Prevalence of the Metabolic Syndrome in Healthy Middle-Aged Men
  • 2011
  • Ingår i: Angiology. - 1940-1574.
  • Tidskriftsartikel (refereegranskat)abstract
    • The metabolic syndrome (MetS) is characterized by a constellation of factors that confer an increased risk for cardiovascular morbidity and mortality. It is well-known that physical activity (PA) has a protective role on cardiovascular morbidity and mortality, mainly through its favorable effects on traditional risk factors such as body mass and blood pressure (BP). We assessed the prevalence of MetS in a population-based sample of 58-year-old men with respect to leisure-time PA and also to occupational PA. The results showed an inverse linear association (P < .05) between leisure time physical activity (LTPA) and MetS in this group. In conclusion, this study suggests that PA has an important role in controlling MetS.
  • Behre, Carl Johan, 1968-, et al. (författare)
  • Moderate physical activity is associated with lower apoB/apoA-I ratio, independently of other risk factors in healthy middle-aged men.
  • 2010
  • Ingår i: Angiology. - 0003-3197. ; 61:8, s. 775-779
  • Tidskriftsartikel (refereegranskat)abstract
    • Low-density lipoprotein is recognized as a primary vascular risk factor. However, recent data favor apolipoprotein (apo)B and apoA-I as risk factors with higher predictive values than conventional lipids. We investigated how leisure-time physical activity relates to the serum apoB/apoA-I ratio in middle-aged men. The results showed that compared with a sedentary lifestyle, moderate physical activity was associated with a decreased apoB/apoA-I ratio (1.01 ± 0.28 vs 0.87 ± 0.24, P < .05) and increased apoA-I levels (1.30 ± 0.20 g/L vs 1.43 ± 0.22 g/L, P < .05), whereas vigorous activity was required to observe a reduction in apoB levels (1.27 ± 0.28 g/L vs 1.14 ± 0.24 g/L, P < .05). A covariate analysis showed that leisure time physical activity was also associated with reduced apoB/apoA-I ratios after adjustment for smoking, systolic blood pressure and waist circumference. Importantly, this association was seen at moderate levels of physical activity, supporting the notion that some activity is better than none.
  • Bergström, Ulf, et al. (författare)
  • Pulmonary dysfunction, smoking, socioeconomic status and the risk of developing rheumatoid arthritis.
  • 2011
  • Ingår i: Rheumatology (Oxford, England). - 1462-0332. ; 50, s. 2005-2013
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives. Environmental risk factors are of potential interest for both prevention and treatment of RA. The purpose of this study was to examine the effect of pulmonary function, smoking and socio-economic status on the future risk of RA. Methods. Between 1974 and 1992, 22 444 men and 10 902 women were included in the Malmö Preventive Medicine Program (MPMP). Pulmonary function was assessed by a standard screening spirometry. Chronic obstructive pulmonary disease (COPD) and restrictive pulmonary dysfunction were defined based on pulmonary function tests. Individuals who developed RA were identified by linking the MPMP database to national and local RA registers. The patients were classified according to the 1987 ACR criteria for RA. Four matched controls for every case were selected. Results. We identified 290 cases of incident RA (151 men/139 women; mean age at diagnosis 60 years). The median time from inclusion to diagnosis was 12 years. Forced vital capacity and forced expiratory volume within 1 s values were similar in cases and controls, overall and also in separate analysis of those screened ≤8 years before diagnosis. There was no association between COPD or restrictive pulmonary dysfunction and subsequent development of RA. Current smoking was a strong predictor for RA odds ratio (OR) 1.79; 95% CI 1.32, 2.42. Blue-collar workers had an increased risk of RA (OR 1.54; 95% CI 1.12, 2.10), independent of smoking. Conclusion. Pulmonary dysfunction did not predict RA, but smoking and low socio-economic status were independent risk factors for RA. Other effects of smoking may be important for RA susceptibility
  • Elias, Erik, 1979-, et al. (författare)
  • Erythrocyte sodium-lithium countertransport activity is inversely correlated to adiponectin, retinol binding protein 4 and body height.
  • 2010
  • Ingår i: Scandinavian journal of clinical and laboratory investigation. - 1502-7686. ; 70:7, s. 487-91
  • Tidskriftsartikel (refereegranskat)abstract
    • We have previously described that the sodium/lithium countertransport (SLC) in the erythrocyte cell membrane is closely linked to obesity and insulin resistance. Adiponectin and retinol-binding protein 4 (RBP-4) are believed to affect obesity and insulin resistance. In the present study, we aimed to further characterize the relationship between SLC, inflammatory markers, adiponectin and RBP-4.
  • Fagerberg, Björn, 1943-, et al. (författare)
  • Differences in lesion severity and cellular composition between in vivo assessed upstream and downstream sides of human symptomatic carotid atherosclerotic plaques
  • 2010
  • Ingår i: Journal of Vascular Surgery. - 1423-0135. ; 47:3, s. 221-230
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The heterogeneous structure of carotid atherosclerotic plaques may be better understood if it is related to blood flow variations, influencing gene expression and cellular functions. Upstream of the maximum stenosis there is laminar blood flow and high shear stress, downstream there is turbulence and low shear stress. We studied if these variations were associated with differences in plaque morphology and composition between sites located up- and downstream of the maximum stenosis in symptomatic carotid plaques. Methods: Patients with symptomatic carotid stenosis were examined with magnetic resonance angiography to localize the maximum stenosis in-vivo, prior to endarterectomy. In 41 endarterectomized specimens, transverse tissue sections prepared up- and downstream of the maximum stenosis were compared using histopathology and immunohistochemistry. Results: The location of maximum stenosis relative the carotid bifurcation varied considerably between plaques. Compared with the downstream side, the upstream side of the stenosis had higher incidence of severe lesions with cap rupture and intraplaque hemorrhage, more macrophages, less smooth muscle cells and more collagen. Conclusions: The up- and downstream sides of symptomatic carotid plaques differed in plaque morphology and composition. This implies that the intraplaque location of sampling sites may be a confounding factor in studies of atherosclerotic plaques.
  • Johansson, Karin, et al. (författare)
  • Ankle-Brachial Index Should Be Measured in Both the Posterior and the Anterior Tibial Arteries in Studies of Peripheral Arterial Disease
  • 2010
  • Ingår i: Angiology. - 0003-3197. ; 61:8, s. 780-783
  • Tidskriftsartikel (refereegranskat)abstract
    • Lower extremity peripheral artery disease (PAD) is a powerful predictor of cardiovascular events and mortality. The ankle-brachial index (ABI) is an objective and standard diagnostic method to diagnose PAD (an ABI ≤0.9 is considered pathological). The American Heart Association (AHA) and the American College of Cardiology (ACC) recommend using both the posterior- and anterior tibial arteries when assessing ABI. We investigated if there was a difference in the diagnosis of PAD if the ABI was measured in the posterior- or the anterior tibial artery. The results showed that among subjects with ABI ≤0.9, between 30% and 40% would not get a PAD diagnosis if the ABI was measured in only 1 of the arteries. In conclusion, this study emphasizes the importance of measuring the ABI in both the posterior tibial and the anterior tibial arteries when diagnosing PAD.
  • Lundberg, Per, et al. (författare)
  • Viltpopulationer och deras dynamik
  • 2010
  • Ingår i: Vilt, människa, samhälle. - Stockholm : Liber. - 978-91-47-09418-9 ; s. 53-79
  • Bokkapitel (populärvet., debatt m.m.)
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