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Sökning: WFRF:(Bergström Göran) > (1995-1999) > Refereegranskat

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  • Adami, Johanna, et al. (författare)
  • Smoking and the risk of leukemia, lymphoma, and multiple myeloma (Sweden)
  • 1998
  • Ingår i: Cancer Causes and Control. - 0957-5243 .- 1573-7225. ; 9:1, s. 49-56
  • Tidskriftsartikel (refereegranskat)abstract
    • While several epidemiologic studies have indicated a link between smoking and the risk of developing hematolymphoproliferative cancers (chiefly leukemias, lymphomas, and multiple myelomas), in particular myeloid leukemia, the role of tobacco in the etiology of these neoplasms remains unclear. To evaluate the potential impact of tobacco use on development of leukemia, lymphoma, and multiple myeloma, we conducted a cohort study of 334,957 Swedish construction workers using prospectively collected exposure-information with complete long-term follow-up. A total of 1,322 incident neoplasms occurred during the study period, 1971-91. We found no significant association between smoking status, number of cigarettes smoked, or duration of smoking and the risk of developing leukemias, lymphomas, or multiple myeloma. There was a suggestion of a positive association between smoking and the risk of developing Hodgkin's disease, although the rate ratios were not significantly elevated, except for young current smokers. No positive dose-risk trends emerged. Our study provides no evidence that smoking bears any major relationship to the occurrence of leukemias, non-Hodgkin's lymphomas, or multiple myeloma.
  • Fu, Michael, 1963-, et al. (författare)
  • Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide.
  • 1999
  • Ingår i: Blood pressure. - 0803-7051. ; 8:5-6, s. 317-24
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present study, rats were immunized with angiotensin II receptor subtype 1 (AT1) receptor peptides for 3 months to see if the immunization produced specific anti-AT1 receptor antibodies and if continuous stimulation for 3 months affected blood pressure or induced morphological changes in the organs containing AT1 receptors. Our results showed that there were constant high levels of circulating antibodies throughout the study period in all rats of the immunized group, but not in the control rats, and that there were almost no significant cross-reactions of antisera with AT2 receptor peptide and alpha1 adrenoceptor peptide, except in four rats, which showed low cross-reactions with alpha1 adrenoceptor and AT2 receptor peptides. When an affinity-purified anti-AT1 receptor antibody was used, it specifically displayed the AT1-stimulatory positive chronotropic effect and also localized AT1 receptors. However, in the immunized group, saturation binding of AT1 in homogenates from kidneys showed no difference either in maximal binding sites (Bmax) or in antagonist affinity (Kd). No difference in mRNA of AT1a was found in either kidney or heart, and no morphological changes in the organs were observed, as compared with the control group. Furthermore, immunization did not cause hypertension. In conclusion, the synthetic peptide corresponding to the second extra-cellular loop of the human AT1 receptor was able to produce highly specific and functionally active anti-AT1 receptor antibodies, but unable to induce pathological structural changes or hypertension.
  • Nyrén, Olof, et al. (författare)
  • Smoking and colorectal cancer: : A 20-year follow-up study of Swedish construction workers
  • 1996
  • Ingår i: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - NATL CANCER INSTITUTE. - 0027-8874. ; 88:18, s. 1302-1307
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Although cigarette smoking has consistently been shown to be positively related to the risk of adenomatous polyp development (benign neoplastic growth of epithelial tissue in the colon), most studies of cigarette smoking and the risk of colore
  • Sand, Håkan, et al. (författare)
  • Density-dependent variation in reproduction and body mass in female moose Alces alces
  • 1996
  • Ingår i: Wildlife Biology. - 0909-6396. ; 2:4, s. 233-245
  • Tidskriftsartikel (refereegranskat)abstract
    • Female body mass and reproduction from harvested moose Alces alces were compared in four populations of moose at different stages (densities) of population development, i.e. pre-peak, peak and post-peak, in Sweden during 1961-1991. In two (1 and 2) of the four populations, age-related body mass and reproduction was significantly lower in the post-peak (intermediate density) stage than in the pre-peak stage; whereas for the other two populations (3 and 4), no differences, or higher growth and reproduction at post-peak density, were found. In one population (2) data from all three stages (densities) of population development were available. Age-specific mean body mass was 12.8% lower, and fecundity 46.0% lower (average among age classes), during the peak density stage, than during the pre-peak stage, but did not differ significantly between the peak and post-peak stages, except for fecundity in 1.5-year-old females. In the two populations showing a negative density-dependent response (1 and 2), fecundity decreased more from pre-peak to post-peak density than could be predicted from the reduction in body mass. This suggested a lower reproductive investment per unit body mass at high and intermediate densities, compared to the low density stage. Similar to age-related body growth and fecundity, the proportion of lactating and/or calf-rearing females was significantly lower at post-peak population density in populations 1 and 2 compared to pre-peak densities, but only in the youngest reproducing age class (2.5 years). It is concluded that: i) the large increase in population density has resulted in density-dependent resource limitation, which is expressed as lowered body growth and reproduction in two of the four populations studied; ii) the lower reproductive investment per unit body mass at higher densities may constitute an adaptive strategy to maximise juvenile survival as conditions deteriorate; iii) density-dependent effects in moose may occur at densities which are lower than close to the ecological carrying capacity; and iiii) the variable density-dependent pattern among populations may be due to differential harvest regimes, causing variable post-peak densities, and thus different levels of resource competition among populations.
  • Westerberg, Göran, et al. (författare)
  • Labelling of polysaccharides using [11C]cyanogen bromide : In vivo and in vitro evaluation of 11C-hyaluronan uptake kinetics
  • 1995
  • Ingår i: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 22:2, s. 251-256
  • Tidskriftsartikel (refereegranskat)abstract
    • A method for the 11C-labelling of polysaccharides in high specific radioactivity is described. Dextran and hyaluronan were treated with [11C]cyanogen bromide in aqueous solution at pH 11.5 to give 30-47% radiochemical yields with higher than 98% radiochemical purity in synthesis times of 24-26 min counted from the end of bombardment. Specific radioactivities at the end of synthesis ranged from 0.12 to 3.1 Ci/mumol. The biodistribution kinetics of [11C]hyaluronan injected intravenously was studied in rats by means of positron emission tomography, showing a rapid and displaceable uptake in liver. Uptake and displacement of [11C]hyaluronan was also demonstrated in cultured rat liver endothelial cells.
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