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Träfflista för sökning "WFRF:(Bergström Göran) srt2:(1995-1999);conttype:(refereed)"

Sökning: WFRF:(Bergström Göran) > (1995-1999) > Refereegranskat

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  • Fu, Michael, 1963-, et al. (författare)
  • Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide.
  • 1999
  • Ingår i: Blood pressure. - 0803-7051. ; 8:5-6, s. 317
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present study, rats were immunized with angiotensin II receptor subtype 1 (AT1) receptor peptides for 3 months to see if the immunization produced specific anti-AT1 receptor antibodies and if continuous stimulation for 3 months affected blood pressure or induced morphological changes in the organs containing AT1 receptors. Our results showed that there were constant high levels of circulating antibodies throughout the study period in all rats of the immunized group, but not in the control rats, and that there were almost no significant cross-reactions of antisera with AT2 receptor peptide and alpha1 adrenoceptor peptide, except in four rats, which showed low cross-reactions with alpha1 adrenoceptor and AT2 receptor peptides. When an affinity-purified anti-AT1 receptor antibody was used, it specifically displayed the AT1-stimulatory positive chronotropic effect and also localized AT1 receptors. However, in the immunized group, saturation binding of AT1 in homogenates from kidneys showed no difference either in maximal binding sites (Bmax) or in antagonist affinity (Kd). No difference in mRNA of AT1a was found in either kidney or heart, and no morphological changes in the organs were observed, as compared with the control group. Furthermore, immunization did not cause hypertension. In conclusion, the synthetic peptide corresponding to the second extra-cellular loop of the human AT1 receptor was able to produce highly specific and functionally active anti-AT1 receptor antibodies, but unable to induce pathological structural changes or hypertension.
  • Nyrén, Olof, et al. (författare)
  • Smoking and colorectal cancer: : A 20-year follow-up study of Swedish construction workers
  • 1996
  • Ingår i: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - NATL CANCER INSTITUTE. - 0027-8874. ; 88:18, s. 1302-1307
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Although cigarette smoking has consistently been shown to be positively related to the risk of adenomatous polyp development (benign neoplastic growth of epithelial tissue in the colon), most studies of cigarette smoking and the risk of colore
  • Westerberg, Göran, et al. (författare)
  • Labelling of polysaccharides using [11C]cyanogen bromide : In vivo and in vitro evaluation of 11C-hyaluronan uptake kinetics
  • 1995
  • Ingår i: Nuclear Medicine and Biology. - 0969-8051. ; 22:2, s. 251-256
  • Tidskriftsartikel (refereegranskat)abstract
    • A method for the 11C-labelling of polysaccharides in high specific radioactivity is described. Dextran and hyaluronan were treated with [11C]cyanogen bromide in aqueous solution at pH 11.5 to give 30-47% radiochemical yields with higher than 98% radiochemical purity in synthesis times of 24-26 min counted from the end of bombardment. Specific radioactivities at the end of synthesis ranged from 0.12 to 3.1 Ci/mumol. The biodistribution kinetics of [11C]hyaluronan injected intravenously was studied in rats by means of positron emission tomography, showing a rapid and displaceable uptake in liver. Uptake and displacement of [11C]hyaluronan was also demonstrated in cultured rat liver endothelial cells.
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