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Sökning: WFRF:(Dabelsteen Erik)

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  • Moltesen, Maria, et al. (författare)
  • Cognitive appraisal of aversive stimulus differs between individuals with contrasting stress coping styles; evidences from selected rainbow trout (Oncorhynchus mykiss) strains
  • 2016
  • Ingår i: Behaviour. - 0005-7959 .- 1568-539X. ; 153:13-14, s. 1567-1587
  • Tidskriftsartikel (refereegranskat)abstract
    • In animals, personality variations in response to stress and energy demands have been established. Cognitive processing of negative stimuli correlates with stress response patterns. Still, the relative contribution of cognitive appraisal or physiological demands to the behavioural output needs to be clarified. In this study we utilized reactive (high-responsive, HR) and proactive (low-responsive, LR) rainbow trout strains to investigate how contrasting reactions to hypoxia are related to individual variation in metabolism and/or cognition. The HR-LR strains did not differ in standard metabolic rate or hypoxia tolerance. HR trout displayed more pronounced avoidance to a signal cue after being conditioned with hypoxia, suggesting that they experienced this stimulus more aversive than LR trout. Together with differences in forebrain c-fos activation patterns in dorsomedial pallium, these results suggest cognitive differences between the strains. These results demonstrate that differences in personality/stress coping style can be related to contrasts in cognition, which are independent of metabolic differences.
  • Reit, Claes, 1946-, et al. (författare)
  • Diagnostiske grundbegreber
  • 2004
  • Ingår i: Dabelsteen, E. Sund eller syg? En teoretisk baggrund för diagnostik.. - 87-991763-0-0 ; s. 41-61
  • Bokkapitel (övrigt vetenskapligt)
  • Thurfjell, Niklas, et al. (författare)
  • Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck.
  • 2005
  • Ingår i: Advances in Oto-Rhino-Laryngology. - 0065-3071. ; 62, s. 49-57
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53. METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours. RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.
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