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Sökning: WFRF:(Ehrnström Roy) > (2005-2009)

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1.
  • Büchner, Frederike L, et al. (författare)
  • Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
  • 2009
  • Ingår i: International Journal of Cancer. - 0020-7136 .- 1097-0215. ; 125:11, s. 2643-2651
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among never smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrated HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. (c) 2009 UICC.</p>
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2.
  • Buechner, Frederike L., et al. (författare)
  • Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
  • 2009
  • Ingår i: International Journal of Cancer. - John Wiley and Sons Inc.. - 0020-7136. ; 125:11, s. 2643-2651
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among fever smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrate HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. (c) 2009 UICC
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3.
  • Ceder, Jens, et al. (författare)
  • The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.
  • 2008
  • Ingår i: European Urology. - Elsevier. - 1873-7560. ; 53:3, s. 524-532
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Questions regarding the cell source and mechanisms in the initiation and progression of prostate cancer are today still open for debate. Indeed, our knowledge regarding prostate cell regulation, self-renewal, and cytodifferentiation is presently rather limited. In this study, we investigated these processes in the normal adult human prostate. METHODS: Dynamic expression patterns in prostate stem/progenitor cells, intermediate/transit-amplifying cells, and cell lineages were immunohistochemically identified in an in situ explant renewal model of the human normal/benign adult prostate (n=6). RESULTS: Cells with a basal phenotype proliferated significantly in explant cultures, whereas luminal cells went into apoptosis. Results further show down-regulation in tissue cultures of the basal and hypothetical stem cell marker Bcl-2 in the majority of cells, except in rare putative epithelial stem cells. Investigation of established (AC133) and novel candidate prostate stem/progenitor markers, including the cell surface receptor tyrosine kinase KIT and its ligand stem cell factor (SCF), showed that these rare epithelial cells are AC133(+)/CD133(low)/Bcl-2(high)/cytokeratin(+)/vimentin(-)/KIT(low)/SCF(low). In addition, we report on a stromal population that expresses the mesenchymal marker vimentin and that is AC133(-)/CD133(high)/Bcl-2(-)/cytokeratin(-)/KIT(high)/SCF(high). CONCLUSIONS: We provide evidence for epithelial renewal in response to tissue culture and for basal and epithelial stem/progenitor cell recruitment leading to an expansion of an intermediate luminal precursor phenotype. Data further suggest that SCF regulates prostate epithelial stem/progenitor cells in an autocrine manner and that all or a subset of the identified novel stromal phenotype represents prostate stromal progenitor cells or interstitial pacemaker cells or both.
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5.
  • Egevad, Lars, et al. (författare)
  • Primary seminal vesicle carcinoma detected at transurethral resection of prostate
  • 2007
  • Ingår i: Urology. - Elsevier. - 1527-9995. ; 69:4
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a case of primary seminal vesicle carcinoma detected at transurethral resection. The clinical presentation, radiologic findings, and pathologic features of these tumors are reviewed. Grossly, seminal vesicle carcinoma is poorly circumscribed and solid or solid/cystic and may be misinterpreted as an abscess or hemorrhage on radiologic examination. Although a definitive diagnosis often cannot be given until after complete resection, we describe the findings indicative of seminal vesicle origin, including papillary histologic architecture, sometimes with mucinous differentiation, and a characteristic immunophenotype positive for CA-125 and cytokeratin 7, but negative for prostate-specific antigen and cytokeratin 20. UROLOGY 69: 778.e11-78.e13, 2007.
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6.
  • Egevad, Lars, et al. (författare)
  • Urachal signet-cell adenocarcinoma
  • 2009
  • Ingår i: Scandinavian Journal of Urology and Nephrology. - Taylor & Francis. - 0036-5599. ; 43:1, s. 88-91
  • Tidskriftsartikel (refereegranskat)abstract
    • This report presents two cases of urachal signet-cell adenocarcinoma (USCA). Two men, aged 53 and 51 years, presented with haematuria. Cystoscopy showed tumours in the dome of the bladder and transurethral resection revealed signet ring cell carcinoma. They both underwent cystoprostatectomy but died of metastatic disease after 14 and 26 months. USCA is a very rare tumour with poor prognosis. Only 25 cases have been reported. The tumours have a specific gross and microscopic morphology but must be distinguished from metastases of signet ring cell originating from other sites. Immunohistochemistry is helpful for the determination of the primary site.
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7.
  • Ehrnström, Roy (författare)
  • Carbonate Ions and Gastric Cancer
  • 2007
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • Popular Abstract in Swedish Nästan en miljon nya fall av magsäckscancer diagnostiseras årligen världen över. Även om frekvensen har fallit dramatiskt de senaste åren så är magsäckscancern fortfarande den näst vanligaste orsaken till död i cancer sett ur ett världsperspektiv. Den geografiska variationen av denna cancertyp är anmärkningsvärd med den högsta förekomsten i asiatiska länder såsom Japan, Korea och Kina. Denna världsomspännande variation är sannolikt förknippad med riskfaktorer som går att förändra och de två riskfaktorer som dominerat debatten de senaste tio åren är: magsårsbakterien Helicobacter pylori och kostfaktorer. Frekvensen av spontan magsäckscancer hos råtta är en raritet och detta har lett till att man med olika experimentella metoder försökt orsaka macksäckscancer. I vår första studie opererade vi bort nedersta delen av magsäcken för att skapa en reflux av de vätskor som finns i tolvfingertarmen, bukspottskörteln samt galla in i magsäcken och på så sätt utveckla spontan tumörbildning. I denna djurförsöksmodell studerades olika födoämnes-faktorers effekt på uppkomsten av magsäckscancer bland 256 manliga Wistar råttor. I den första omgången av studien fann vi överraskande att föda som tillförts kalciumkarbonat mer än trefalt ökade tumörförekomsten jämfört med kontroll gruppen (61% mot 17%). Genom att byta kalciumjoner mot natriumjoner kunde vi i en andra omgång av försöket visa att det var karbonatjonen som var ansvarig för den betydande ökningen av antalet cancrar (54% mot 12%). I både kliniska och experimentella studier är reflux av vätskor från tolvfingertarmen sammankopplad med utvecklingen av magsäckscancer. Dessutom är det visat att det är vätskan från bukspottskörteln och tolvfingertarmen snarare än gallan som är ansvarig för tumörutvecklingen och att dessa vätskor är särdeles rik på karbonatjoner. I den sista studien undersökte vi uttrycket av olika cancer relaterade proteiner såsom COX-2 och ODC samt tillväxtaktiviteten med hjälp av Ki67 i normal magsäcksslemhinna från opererade råttor för att kunna bedöma betydelsen av karbonatjoner för cancerutvecklingen. Resultaten visar att om man opererar bort nedersta delen av magsäcken ökar COX-2 uttrycket och tillväxtaktiviteten mätt med Ki67 stegras. Tillägg av karbonatjoner i födan ökar inte COX-2 nivåerna ytterliggare. Emellertid, bland opererande försöksdjur som erhållit kost med tillägg av karbonatjoner fann vi ett kraftigt förhöjt uttryck av ODC parallellt med en kraftigt stegrad tillväxtaktivitet. Det förefaller som om en enträgen kronisk inflammation med ökade COX-2 nivåer, förorsakad av till exempelvis reflux eller H pylori infektion, ökar risken att utveckla magsäckscancer. Föda med tillsats av karbonatjoner ökar påtagligt nivåerna av ODC i en COX-2-beroende miljö som i sin tur resulterar i en ytterliggare höljning av tillväxtaktiviteten och en ännu högre risk för utveckling av magsäckscancer.
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10.
  • Magnusson, Cecilia, et al. (författare)
  • An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation
  • 2007
  • Ingår i: Cancer Research. - American Association for Cancer Research Inc.. - 1538-7445. ; 67:19, s. 9190-9198
  • Tidskriftsartikel (refereegranskat)abstract
    • Increased levels of inflammatory mediators such as cystenyl leukotrienes (CysLT) have been found in and around tumors. These data, along with our previous observation that the G-protein-coupled receptor CysLT(1)R, which signals survival and proliferation, is up-regulated in colon cancer, suggest an important role for CysLT(1)R in tumor development. The objective of this study was to examine the expression and function of the low-affinity CysLT(2) receptor (CysLT(2)R) in colon cancer. We found lower expression levels of CysLT(2)R compared with CysLT(1)R in cancer cell lines as well as clinical tumor material. Interestingly, CysLT(2)R, like CysLT(1)R, was found to be one of few G-protein-coupled receptors that are located both at the plasma membrane and the nuclear membrane. No effect of CysLT(2)R signaling on cell proliferation was observed, nor was there a correlation between CysLT2R and different proliferation markers such as KI-67 and cyclooxygenase-2 in the tumor material. Instead, we found that activation of this receptor in colon cancer cells led to cellular differentiation similar to the effects of butyrate treatment. In accordance with this finding, we found that reduced expression of CysLT(2)R in colon cancer was associated with poor prognosis. We report the novel finding that CysLT(2)R signaling leads to terminal differentiation of colon carcinoma cells and growth inhibition, and that its expression is relatively high in less malignant forms of colon cancer. These data suggest that the balance between these two receptors is important for tumor progression and disease outcome.
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