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Sökning: WFRF:(Friberg Sven)

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  • Enfors, Sven-Olof, et al. (författare)
  • Physiological responses to mixing in large scale bioreactors
  • 2001
  • Ingår i: Journal of Biotechnology. - 0168-1656. ; 85:2, s. 175-185
  • Tidskriftsartikel (refereegranskat)abstract
    • Escherichia coli fed-batch cultivations at 22 m(3) scale were compared to corresponding laboratory scale processes and cultivations using a scale-down reactor furnished with a high-glucose concentration zone to mimic the conditions in a feed zone of the large bioreactor. Formate accumulated in the large reactor, indicating the existence of oxygen limitation zones. It is suggested that the reduced biomass yield at large scale partly is due to repeated production/reassimilation of acetate from overflow metabolism and mixed acid fermentation products due to local moving zones with oxygen limitation. The conditions that generated mixed-acid fermentation in the scale-down reactor also induced a number of stress responses, monitored by analysis of mRNA of selected stress induced genes. The stress responses were relaxed when the cells returned to the substrate limited and oxygen sufficient compartment of the reactor. Corresponding analysis in the large reactor showed that the concentration of mRNA of four stress induced genes was lowest at the sampling port most distant from the feed zone. It is assumed that repeated induction/relaxation of stress responses in a large bioreactor may contribute to altered physiological properties of the cells grown in large-scale bioreactor. Flow cytometric analysis revealed reduced damage with respect to cytoplasmic membrane potential and integrity in cells grown in the dynamic environments of the large scale reactor and the scale-down reactor.
  • Friberg, Anders, et al. (författare)
  • Recognition of the Main Melody in a Polyphonic Symbolic Score using Perceptual Knowledge
  • 2009
  • Ingår i: Journal of New Music Research. - 0929-8215. ; 38:2, s. 155-169
  • Tidskriftsartikel (refereegranskat)abstract
    • It is in many cases easy for a human to identify the main melodic theme when listening to a music example. Melodic properties have been studied in several research projects, however, the differences between properties of the melody and properties of the accompaniment (non-melodic) voices have not been addressed until recently. A set of features relating to basic low-level statistical measures were selected considering general perceptual aspects. A new 'narrative' measure was designed intended to capture the amount of new unique material in each voice. The features were applied to a set of scores consisting of about 250 polyphonic ringtones consisting of MIDI versions of contemporary pop songs. All tracks were annotated into categories such as melody and accompaniment. Both multiple regression and support vector machines were applied on either the features directly or on a Gaussian transformation of the features. The resulting models predicted the correct melody in about 90% of the cases using a set of eight features. The results emphasize context as an important factor for determining the main melody. A previous version of the system has been used in a commercial system for modifying ring tones.
  • Friberg, Bertil, 1950-, et al. (författare)
  • One-year prospective three-center study comparing the outcome of a "soft bone implant" (prototype Mk IV) and the standard Brånemark implant.
  • 2003
  • Ingår i: Clinical implant dentistry and related research. - 1523-0899. ; 5:2, s. 71
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Oral implant treatment ad modum Brånemark has been used for decades in the rehabilitation of edentate and partially dentate patients. Posterior jaw regions frequently exhibit bone of poor texture, and it is often difficult to obtain primary stability. Thus, it may prove beneficial to deviate from the original protocol and to use implants with a modified design, for example, with a slightly tapered geometry. PURPOSE: The purpose of the investigation was to compare the early behavior of a modified (prototype Mk IV, Brånemark System, Nobel Biocare AB, Gothenburg, Sweden; test) implant with that of the standard Brånemark implant (control) in regions of mainly type 4 bone. MATERIALS AND METHODS: Three Swedish centers participated, and a total of 44 patients were treated with oral implants for 39 maxillas and 5 mandibles. The study focused on the most distal right and left implant sites (88 implants), which were randomized to receive either a test or a control implant. Various parameters were recorded, such as registered insertion torque (OsseoCare), Nobel Biocare AB), wobbling during insertion, primary and secondary stability (as measured with resonance frequency), and marginal bone loss. The implants were followed up for 1 year. RESULTS: The test implant more frequently required a higher insertion torque and showed a significantly higher primary stability than the control implant. This difference in stability leveled out over time, and test and control implants exhibited similar secondary stability at abutment operation and at the 1-year visit. Wobbling during insertion was rarely recorded for either of the implant designs. The 1-year cumulative success rate was 93.1% for test implants and 88.4% for control implants. CONCLUSIONS: The modified implant design resulted in an increased primary stability, which may be important when placing implants in jaw regions of type 4 bone. However, independent of the achieved primary stability, successful implants tended to approach similar secondary stability in the two designs tested.
  • Nielsen, Niklas, et al. (författare)
  • Successful resuscitation with mechanical CPR, therapeutic hypothermia and coronary intervention during manual CPR after out-of-hospital cardiac arrest
  • 2005
  • Ingår i: Resuscitation. - Elsevier. ; 65:1, s. 111-113
  • Tidskriftsartikel (refereegranskat)abstract
    • A 62-year-old man suffered out-of-hospital cardiac arrest and was treated with mechanical compression-decompression during transport to the hospital. In the emergency department, 28 min after cardiac arrest, spontaneous circulation returned briefly but the patient rapidly became asystolic and mechanical compression-decompression was again applied. After further resuscitation a spontaneous circulation returned and the patient was transferred, deeply comatose, to the coronary intervention laboratory while therapeutic hypothermia was induced. In the laboratory the heart arrested again and coronary angiography was performed during manual CPR revealing a left main stem occlusion. After successful reperfusion of the heart the patient was transferred to the intensive care unit with an intra-aortic balloon pump. The patient was treated with hypothermia for 24 h and awoke without neurological sequelae after a sustained intensive care period of 13 days. The present case is an example of how modern resuscitation principles implementing new clinical and experimental findings may strengthen the chain of survival during resuscitation.
  • Nilsson, Kjell G, et al. (författare)
  • Assessment of horizontal laminar air flow instrument table for additional ultraclean space during surgery
  • 2010
  • Ingår i: Journal of Hospital Infection. - Elsevier. - 0195-6701. ; 76:3, s. 243-246
  • Tidskriftsartikel (refereegranskat)abstract
    • The area in a vertical ultraclean laminar air flow (LAF) theatre is usually too small to accommodate all the equipment needed for major surgery. We investigated the addition of an instrument table supplied with fixed ultraclean LAF and placed alongside the existing main LAF unit, to determine its physical and bacteriological effect on the main unit. In phase 1, with two investigators but without a patient, smoke tests showed no intrusion of air from the table into the main unit and particle counts did not show any adverse effect on the main LAF unit. In phase 2, during patients undergoing two total knee replacements, the LAF table and a table without LAF were placed alongside the main LAF unit. The tables were subjected to the activity of an extra operating room (OR) nurse working from inside the main LAF vigorously simulating handling of instruments. During this activity, the >5 ?m particle counts were 275/m3 at the instrument table with LAF and 8550/m3 at the table without LAF (P < 0.0001). Also, without the OR nurse activity, the particle counts, just inside the main unit and adjacent to the LAF table, were significantly reduced (P < 0.03–0.003). Sedimentation plates on the LAF table and in the main unit registered 22 and 25 cfu/m2/h respectively compared with 45 cfu/m2/h at the instrument table without LAF. In conclusion, the results from the smoke tests, particle counts and bacteriological evaluation showed that the additional instrument table supplied with LAF is efficient and can be safely used as an extension additional to a main OR LAF unit.
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