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Sökning: WFRF:(Graf Wilhelm) > (2015-2019) > (2016)

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  • Casey, Charles P., et al. (författare)
  • Quantitative Determination of the Regioselectivity of Nucleophilic Addition to η3-Propargyl Rhenium Complexes and Direct Observation of an Equilibrium between η3-Propargyl Rhenium Complexes and Rhenacyclobutenes.
  • 2009
  • Ingår i: Organometallics. - 0276-7333 .- 1520-6041. ; 28:1, s. 123-131
  • Tidskriftsartikel (refereegranskat)abstract
    • PMe3 adds selectively to the central C of the η3-propargyl complex [C5Me5(CO)2Re(η3-CH2C≡CCMe3)][BF4] (1-t-Bu) to form the metallacyclobutene [C5Me5(CO)2Re(CH2C(PMe3):CCMe3)][BF4] (7). The rate of rearrangement of the metallacyclobutene 7 to η2-alkyne complex [C5Me5(CO)2Re(η2-Me3PCH2C≡CCMe3)][BF4] (8) is independent of phosphine concn., consistent with a dissociative mechanism proceeding via η3-propargyl complex 1-t-Bu. The rate of this rearrangement is 480 times slower than the rate of exchange of PMe3 with the labeled metallacyclobutene 7-d9. This rate ratio provides an indirect measurement of the regioselectivity for addn. of PMe3 to the central C of η3-propargyl complex 1-t-Bu to give 7 compared to addn. to a terminal C to give 8. The addn. of PPh3 to 1-t-Bu gives the metallacyclobutene [C5Me5(CO)2Re(CH2C(PPh3):CCMe3)][BF4] (11). Low-temp. 1H NMR spectra provide evidence for an equil. between metallacyclobutene 11 and η3-propargyl complex 1-t-Bu (Keq ≈ 44 M-1 at -46° and ΔG°(0°) = -1.2 ± 0.2 kcal mol-1). The crystal and mol. structures of [C5Me5(CO)2Re[η2-(Ar2PCH2CH2PPh2)CH2C≡CCMe3]][BF4]·2CH2Cl2 (Ar = 3,5-(CF3)2C6H3) and [C5Me5(CO)2Re(η2-Me3PCH2C≡CCMe3)]Cl·H2O were detd. by x-ray crystallog. [on SciFinder(R)]
  • Enberg, U., et al. (författare)
  • Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors
  • 2009
  • Ingår i: Journal of Endocrinological Investigation. - 0391-4097 .- 1720-8386. ; 32:10, s. 810-815
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Due to increased use of imaging techniques, adrenal incidentalomas are frequently detected. The majority are non-hyperfunctioning adrenocortical tumors. We have previously shown that expression of the gene CYP17, coding for the enzyme in the cortisol pathway, correlates with cortisol release from adrenocortical tumors in vitro. The aim of this study was to compare clinical data with mRNA expression of CYP17 and CYP11B1 in adrenocortical tumors from patients with and without Cushing's syndrome and to identify adrenal tumors that may cause subclinical Cushing's syndrome. DESIGN: A retrospective study of 34 patients undergoing adrenalectomy due to an adrenal tumor. METHODS: Clinical data were collected. In the adrenal gland the mRNA expression of the genes CYP17 and CYP11B1 was studied with in situ hybridisation technique. RESULTS: The median ratio of CYP17/CYP11B1 expression in tumors from patients with Cushing's syndrome was significantly higher than the median ratio in the non-hyperfunctioning tumors. Tumors from 2 patients with subclinical Cushing's syndrome had ratios within the upper range for non-hyperfunctioning tumors. CONCLUSIONS: The ratio between the expression of the genes CYP17 and CYP11B1 in tumors from patients with Cushing's syndrome is significantly higher than in the non-hyperfunctioning tumors. This indicates that 17alpha-hydroxylase is a major determinant of cortisol overproduction. The patients with subclinical Cushing's syndrome in this study are too few to draw any firm conclusions although the results suggest that subclinical Cushing's syndrome may be identified post-operatively with this method.
  • Graf, Heike (författare)
  • What Structures? : A communicative approach to ethnic diversity in German media companies
  • 2017
  • Ingår i: Journalism Practice. - : Routledge. - 1751-2786 .- 1751-2794. ; 11:5, s. 544-558
  • Tidskriftsartikel (refereegranskat)abstract
    • This article examines how the topic of an ethnically diverse workforce can become an organiz- ational problem (or not) in private media companies. The study is based on interviews with Human Resources managers and persons responsible for diversity issues at these companies. This article favors a communicative approach by relating structures to agency through the concept of expectation. This is in contrast to the bulk of media research, which considers structures as something fixed and objective in determining organizational action. By exploring the expec- tations structures we can see which expectation patterns condition organizational communication. As a result, the main pattern of migrant background as adding value to the organization (or not) could be revealed as a guiding distinction in organizational communication about diverse workforces. 
  • Linder, Arne, et al. (författare)
  • Using the carbon dioxide laser for tonsillotomy in children
  • 1999
  • Ingår i: International Journal of Pediatric Otorhinolaryngology. - 0165-5876 .- 1872-8464. ; 50:1, s. 31-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Carbon dioxide laser tonsillotomies were performed on 33 children aged 1-12 years for the relief of obstructive symptoms due to tonsillar hyperplasia. As opposed to conventional tonsillectomy, only the protruding part of each tonsil was removed. A carbon dioxide laser delivering 20 W was used for the excision. Twenty-one children were seen in active short-term follow-up and the records of all the children were checked for possible surgery related events up to 20-33 months after surgery. Laser tonsillotomy was uniformly effective in relieving the obstruction, with good hemostasis. The tonsillar remnants healed completely within 2 weeks. No major adverse events occurred. Post-operative pain appeared slight and easily controlled. There was no gain in operating time compared with conventional tonsillectomy. The laser tonsillotomies were in most cases done in day surgery. No recurrence of obstructive problems was reported up to 20-33 months after surgery. It was concluded that tonsillotomy, using a carbon dixoide laser, is a valid treatment for obstructive symptoms caused by enlarged tonsils, which can be performed with little bleeding and post-operative pain. The improved hemostasis may enable a shift from in-patient to day surgery.
  • Sintorn, Erik, 1980, et al. (författare)
  • Sample Based Visibility for Soft Shadows using Alias-free Shadow Maps
  • 2008
  • Ingår i: Computer Graphics Forum (Proceedings of the Eurographics Symposium on Rendering 2008). ; 27:4, s. 1285-1292
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper introduces an accurate real-time soft shadow algorithm that uses sample based visibility. Initially,we present a GPU-based alias-free hard shadow map algorithm that typically requires only a single render passfrom the light, in contrast to using depth peeling and one pass per layer. For closed objects, we also suppress theneed for a bias. The method is extended to soft shadow sampling for an arbitrarily shaped area-/volumetric lightsource using 128-1024 light samples per screen pixel. The alias-free shadow map guarantees that the visibility isaccurately sampled per screen-space pixel, even for arbitrarily shaped (e.g. non-planar) surfaces or solid objects. Another contribution is a smooth coherent shading model to avoid common light leakage near shadow bordersdue to normal interpolation.
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