SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Guan Weihua) srt2:(2018)"

Sökning: WFRF:(Guan Weihua) > (2018)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • de Jong, Simone, et al. (författare)
  • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
  • 2018
  • Ingår i: Communications Biology. - Nature Publishing Group. - 2399-3642. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
2.
  • Otto, Marcia C. de Oliveira, et al. (författare)
  • Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids Results from the CHARGE Consortium
  • 2018
  • Ingår i: PLoS ONE. - 1932-6203 .- 1932-6203. ; 13:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Åtkomst
fritt online (2)
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Lind, Lars, (1)
Landén, Mikael, 1966 ... (1)
Matthews, Keith, (1)
Kogevinas, Manolis (1)
Mattheisen, Manuel, (1)
Milaneschi, Yuri, (1)
visa fler...
Teumer, Alexander, (1)
Boomsma, Dorret I., (1)
Cichon, Sven, (1)
Corvin, Aiden, (1)
Djurovic, Srdjan, (1)
Grabe, Hans J., (1)
Homuth, Georg, (1)
Hottenga, Jouke-Jan, (1)
McIntosh, Andrew M., (1)
McMahon, Francis J., (1)
Melle, Ingrid, (1)
Montgomery, Grant W. ... (1)
Mueller-Myhsok, Bert ... (1)
Nauck, Matthias, (1)
Noethen, Markus M., (1)
Penninx, Brenda W. J ... (1)
Psaty, Bruce M., (1)
Rietschel, Marcella, (1)
Schofield, Peter R., (1)
Smoller, Jordan W., (1)
Tiemeier, Henning, (1)
Uitterlinden, Andre ... (1)
Voelzke, Henry, (1)
Deary, Ian J., (1)
Martin, Nicholas G., (1)
Fornage, Myriam, (1)
Medland, Sarah E., (1)
Adolfsson, Rolf, (1)
Mozaffarian, Dariush (1)
Baune, Bernhard T. (1)
Hu, Frank B., (1)
Jensen, Majken K (1)
Pedersen, Nancy L (1)
Boehnke, Michael (1)
Smith, Caren E., (1)
Pettersson, Erik (1)
Lissowska, Jolanta (1)
Kretzschmar, Warren ... (1)
Rouleau, Guy A. (1)
Del-Favero, Jurgen (1)
Willemsen, Gonneke (1)
Madden, Pamela A. F. (1)
Nyholt, Dale R. (1)
Raychaudhuri, Soumya (1)
visa färre...
Lärosäte
Göteborgs universitet (1)
Umeå universitet (1)
Uppsala universitet (1)
Karolinska Institutet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
År
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy