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Träfflista för sökning "WFRF:(Hansson Karl Johan) "

Sökning: WFRF:(Hansson Karl Johan)

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1.
  • Hansson, Jonas, et al. (författare)
  • Biomarkers of Extracellular Matrix Metabolism (MMP-9 and TIMP-1) and Risk of Stroke, Myocardial Infarction, and Cause-Specific Mortality Cohort Study
  • 2011
  • Ingår i: PLoS ONE. - 1932-6203. ; 6:1, s. e16185
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Turnover of the extracellular matrix in all solid organs is governed mainly by a balance between the degrading matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective.Design: The prospective Uppsala Longitudinal Study of Adult Men (ULSAM) cohort, followed from 1991-1995 for up to 18.1 years. A random population-based sample of 1,082 71-year-old men, no loss to follow-up. Endpoints were all-cause (n = 628), cardiovascular (n = 230), non-cardiovascular (n = 398) and cancer mortality (n = 178), and fatal or non-fatal myocardial infarction (n = 138) or stroke (n = 163).Results: Serum MMP-9 and TIMP-1 levels were associated with risk of all-cause mortality (Cox proportional hazard ratio [HR] per standard deviation 1.10, 95% confidence interval [CI] 1.03-1.19; and 1.11, 1.02-1.20; respectively). TIMP-1 levels were mainly related to risks of cardiovascular mortality and stroke (HR per standard deviation 1.22, 95% CI 1.09-1.37; and 1.18, 1.04-1.35; respectively). All relations except those of TIMP-1 to stroke risk were attenuated by adjustment for cardiovascular disease risk factors. Relations in a subsample without cardiovascular disease or cancer were similar to those in the total sample.Conclusion: In this community-based cohort of elderly men, serum MMP-9 and TIMP-1 levels were related to mortality risk. An altered extracellular matrix metabolism may be involved in several detrimental pathways, and circulating MMP-9 or TIMP-1 levels may be relevant markers thereof.
2.
  • Alsanius, Beatrix, et al. (författare)
  • Ett steg närmare mars
  • 2006
  • Ingår i: Viola. - 0042-6407. ; 24, s. 44-45
  • Tidskriftsartikel (populärvet., debatt m.m.)
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3.
  • Andersson Franko, Mikael, et al. (författare)
  • Modelling the spread of penicillin-resistant Streptococcus pneumoniae in day-care and evaluation of intervention.
  • 2005
  • Ingår i: Statistics in Medicine. - 0277-6715. ; 24:23, s. 3593-607
  • Tidskriftsartikel (refereegranskat)abstract
    • In 1995, a disease control and intervention project was initiated in Malmöhus county in southern Sweden to limit the spread of penicillin-resistant pneumococci. Since most of the carriers of pneumococci are preschool children, and since most of the spread is believed to take place in day-care, a mathematical model, in the form of a stochastic process, for the spread in a day-care group was constructed. Effects of seasonal variation and size of the day-care group were particularly considered. The model was then used for comparing results from computer simulations without and with intervention. Results indicate that intervention is highly effective in day-care groups with more than ten children during the second half of the year.
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  • Nordquist, Birgitta, et al. (författare)
  • Peoples experience of the indoor climate in wind exposed apartments
  • 2010
  • Konferensbidrag (refereegranskat)abstract
    • Apartment buildings have been built in a wind exposed area situated close to the seaside in Malmö, Sweden. Several goals when building these apartments have been articulated, for example low energy usage, validation of the leakage factor and a satisfying indoor environment. The purpose of this study is to examine how the people living in the apartments experience the indoor climate. Their experience has been studied by a questionnaire. 201 persons have responded to the questionnaire. <br /> The overall result in terms of indoor climate and health experience shows a sufficient experience of the indoor climate. One interesting finding is that a factor related to the air-tightness; the experience of draught stands out. The apartments have also been divided into sub-groups and one finding has been that the people in the apartments exposed to wind, the outer layer of the city block, experience a doubled amount of draught compared to the people living inside the city block and sheltered from wind. The results may also be interpretated as that if a building is planned to be built in wind exposed surroundings this issue should be addressed and that a tight building is important to build, also for indoor climate reasons.
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8.
  • Russell, Claire L, et al. (författare)
  • Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates.
  • 2016
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 55:1, s. 303-313
  • Tidskriftsartikel (refereegranskat)abstract
    • Aberrant tau phosphorylation is a hallmark in Alzheimer's disease (AD), believed to promote formation of paired helical filaments, the main constituent of neurofibrillary tangles in the brain. While cerebrospinal fluid (CSF) levels of total tau and tau phosphorylated at threonine residue 181 (pThr181) are established core biomarkers for AD, the value of alternative phosphorylation sites, which may have more direct relevance to pathology, for early diagnosis is not yet known, largely due to their low levels in CSF and lack of standardized detection methods. To overcome sensitivity limitations for analysis of phosphorylated tau in CSF, we have applied an innovative mass spectrometry (MS) workflow, TMTcalibratortrademark, to enrich and enhance the detection of phosphoproteome components of AD brain tissue in CSF, and enable the quantitation of these analytes. We aimed to identify which tau species present in the AD brain are also detectable in CSF and which, if any, are differentially regulated with disease. Over 75% coverage of full-length (2N4R) tau was detected in the CSF with 47 phosphopeptides covering 31 different phosphorylation sites. Of these, 11 phosphopeptides were upregulated by at least 40%, along with an overall increase in tau levels in the CSF of AD patients relative to controls. Use of the TMTcalibratortrademark workflow dramatically improved our ability to detect tau-derived peptides that are directly related to human AD pathology. Further validation of regulated tau peptides as early biomarkers of AD is warranted and is currently being undertaken.
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