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Träfflista för sökning "WFRF:(Hemminki Kari) ;srt2:(2005-2009)"

Sökning: WFRF:(Hemminki Kari) > (2005-2009)

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  • Föregående 12[3]4567...8Nästa
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21.
  • Hemminki, Kari, et al. (författare)
  • Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk
  • 2007
  • Ingår i: Cancer Research. - American Association for Cancer Research Inc.. - 0008-5472. ; 67:3, s. 70-868
  • Tidskriftsartikel (refereegranskat)abstract
    • The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for additive and multiplicative interactions. The Database contained information on 102,176 first breast cancers. Familial risk for breast cancer was 1.76 and the risk for contralateral breast cancer was 3.40, or 5.80 when extrapolated to two breasts. When women had a family history, the risk for contralateral breast cancer was remarkably high, 5.48, or 9.96 when the risk was extrapolated to two breasts, almost identical with 10.21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer.
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22.
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23.
  • Hemminki, Kari, et al. (författare)
  • Survival in breast cancer is familial
  • 2008
  • Ingår i: Breast Cancer Research and Treatment. - Springer. - 0167-6806. ; 110:1, s. 177-182
  • Tidskriftsartikel (refereegranskat)abstract
    • Several earlier studies have assessed survival in breast cancer based on familial risk of this disease. The results have been conflicting and suggest that the risk and prognostic factors of cancer are largely distinct. As a novel concept, we searched for familial clustering of survival, i.e., concordance of survival among family members. We used the nation-wide Swedish Family-Cancer Database to estimate hazard ratios (HRs) for cause-specific and overall survival in invasive breast cancer. HR shows the probability of death in the study group compared the reference group. The study covered 1277 mother-daughter pairs with familial breast cancer. Their median follow-up times for survival ranged from 96 to 122 months. When the survival in daughters was analyzed according to the mothers' length of survival, there was a concordance of prognosis. The HR was 0.65 in daughters whose mothers had survived > = 120 months compared to daughters whose mothers had survived less than 36 months (P-value for trend 0.02). When the analysis was reversed and HRs were derived for mothers, the results were essentially similar (P-value for trend 0.02). The survival did not differ between patients with familial or sporadic breast cancer. The results are consistent in showing that both good and poor survival in breast cancer aggregates in families, which is a novel population-level finding for any cancer. The consistency of the results suggests that the prognosis in breast cancer is in part heritable which is likely to be explained by yet unknown genetic mechanisms.
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24.
  • Ji, Jianguang, et al. (författare)
  • Familial Risk for Esophageal Cancer : An Updated Epidemiologic Study From Sweden
  • 2006
  • Ingår i: Clinical Gastroenterology and Hepatology. - Elsevier. - 1542-3565. ; 4:7, s. 840-845
  • Tidskriftsartikel (refereegranskat)abstract
    • Background & Aims: Familial risks for esophageal cancer are not well known, especially for specific histologic types. Methods: We used the nationwide Swedish Family-Cancer Database to examine familial risks for esophageal cancer in offspring. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were used to calculate the risk. Age standardized incidence rates for specific histology types of esophageal cancer were available from Swedish Cancer Registry. Results: The incidence of male squamous cell carcinoma (SCC) reached its peak rate in 1985 and decreased afterwards. The incidence of adenocarcinoma exceeded that of SCC in 2000 among men. The SIR for offspring esophageal cancer was significantly increased when a parent presented with esophageal cancer (SIR, 2.60). The SIRs for adenocarcinoma were 4.05 and 3.52 when a parent was diagnosed with SCC and any esophageal cancer, respectively; from maternal probands the SIRs were 10.47 and 7.74, respectively. The familial SIR was above unity but not significant for SCC. For associations with other cancer sites, SCC showed a significantly increased risk when a sibling had lung cancer (SIR, 2.52). Conclusions: The present study showed that adenocarcinoma became the major histologic type of esophageal cancer in Swedish men around 2000. For the first time we could show that familial risks of esophageal adenocarcinoma were increased when parents presented with esophageal cancer (particularly SCC). The high risk for adenocarcinoma in such families might be due to heritable effects. However, because of the limited number of familial cases, the results should be interpreted with caution.
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25.
  • Ji, Jianguang, et al. (författare)
  • Familial risk for histology-specific bone cancers : An updated study in Sweden
  • 2006
  • Ingår i: European Journal of Cancer. - Elsevier. - 0959-8049. ; 42:14, s. 2343-2349
  • Tidskriftsartikel (refereegranskat)abstract
    • We used the nation-wide Swedish Family-Cancer Database to examine the familial risks of histology-specific bone cancers in offspring by parental or sibling probands. Adjusted standardised incidence ratios (SIRs) were used to measure the risk. Among the 1327 offspring bone cancers, only two parent-offspring pairs and one sibling pair were noted with concordant bone cancer but the SIRs were not significant. Significant associations were observed in specific histological types or specific age groups, some of which may be chance findings arising from multiple comparisons. However, the risk of early-onset (<25 years) osteosarcoma in offspring was significantly increased when mothers presented with breast cancer (1.7) and melanoma (2.9), suggesting that Li-Fraumeni syndrome could partly explain this familial aggregation. Other associations, such as childhood osteosarcoma with parental liver cancer, Ewing's sarcoma with kidney cancer and giant cell sarcoma with maternal breast cancer, were novel findings and may be related to other familial diseases.
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26.
  • Ji, Jianguang, et al. (författare)
  • Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden
  • 2008
  • Ingår i: Journal of Cancer Research and Clinical Oncology. - Springer. - 0171-5216. ; 134:5, s. 617-624
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer and liposarcoma was associated with parental bladder cancer and maternal breast cancer. Leiomyosarcoma was associated with maternal breast cancer. The associations of myxosarcoma with melanoma and liposarcoma with non-Hodgkin's lymphoma were noted among siblings. Conclusions: The present study showed that familial clustering of soft tissue tumors was limited to specific subtypes. Because of multiple comparisons, some of observed associations may be negative. Aggregation of melanoma and myxosarcoma among siblings may suggest Werner syndrome. A very small proportion of soft tissue sarcomas may be explained by Li-Fraumeni syndrome. Other novel associations, such as offspring liposarcoma with parental bladder cancer, and liposarcoma and non-Hodgkin's lyhphoma among siblings, may be related to other unidentified familial diseases.
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27.
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28.
  • Ji, Jianguang, et al. (författare)
  • Incidence of multiple primary malignancies among patients with bone cancers in Sweden
  • 2006
  • Ingår i: Journal of Cancer Research and Clinical Oncology. - Springer. - 0171-5216. ; 132:8, s. 529-535
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The present study aimed at quantifying risks for second malignancies in patients with bone cancers, and risks for second bone cancers after other primary tumors. Methods: Adjusted standardized incidence ratios (SIRs) were used as a measure of risk. Results: Among 2,546 primary bone cancer patients, a total of 171-second malignancies occurred. Besides second bone cancers, other cancer sites with an increased SIR were the soft tissues and endocrine glands. The overall risk of second malignancies following Ewing's sarcoma was 5.63, followed by chordoma (1.99), osteosarcoma (1.54), and chondrosarcoma (1.51). Patients diagnosed before age 20 years showed an increased SIR of 3.11. The increased occurrence of second bone cancers was noted after the cancer sites of upper aerodigestive tract, kidney and nervous system. Conclusions: The incidence of second primary malignancies in bone cancer patients was moderately increased. Among histological types, Ewing's sarcoma showed the highest risk of developing second cancers. Young age was also associated with an increased risk. Besides therapeutic effects, the observed excesses of a second bone or soft tissue tumor may be related to Li-Fraumeni syndrome. Increases at other sites may be related to unknown factors or spurious findings.
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29.
  • Ji, Jianguang, et al. (författare)
  • Occupation and upper aerodigestive tract cancers : A follow-up study in Sweden
  • 2005
  • Ingår i: Journal of Occupational and Environmental Medicine. - Lippincott Williams & Wilkins. - 1076-2752. ; 47:8, s. 785-795
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: We sought to examine the associations between occupation and upper aerodigestive tract cancers at various anatomic sites. Methods: The Swedish Family-Cancer Database was used to calculate standardized incidence ratios for different occupational groups, adjusted for age, period, and socioeconomic status. Results: Male dentists showed an increased risk for tongue cancer; hairdressers had an increased risk for tongue and larynx cancers among men and pharynx cancer among women; launderers and dry cleaners showed an increased risk for pharynx cancer among men and lip cancer among women; outdoor occupations such as fishermen, seamen, transport, and construction workers showed increased risks for lip cancer. Conclusions: Although smoking and alcohol drinking can explain some of these results, increased risks found for dentists, hairdressers, and launderers and dry cleaners may partly be explained by their work-related exposures; increased risks of lip cancer in outdoor occupations can be explained by sunlight exposure.
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30.
  • Ji, Jianguang, et al. (författare)
  • Occurrences of leukemia subtypes by socioeconomic and occupational groups in Sweden
  • 2005
  • Ingår i: Journal of Occupational and Environmental Medicine. - Lippincott Williams & Wilkins. - 1076-2752. ; 47:11, s. 1131-1140
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The objective of this study was to examine the associations between socioeconomic/Occupational factors and histologic subtypes of leukemia. Methods: The Swedish Family-Cancer Database was used to calculate standardized incidence ratios for different social classes and occupational groups. Results: The overall standardized incidence ratio was close to unity between different socioeconomic groups, except for female manual workers with a significantly decreased risk. Among male occupations, increased nsks were noted for sales agents, seamen, and chemical process workers. For female occupations, increased nsks were observed among mechanics, iron and metalware workers, hairdressers, and launderers and dry cleaners. Conclusions: The present study suggests that socioeconomic/Occupational factors have a minor effect on the nsk of leukemia. Occupational groups with possible exposure to organic solvents and other chemicals such as chemical process workers, mechanics, iron and metalware workers, and launderers and dry cleaners may entail true risk for leukemia.
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