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Sökning: WFRF:(Hildingsson Christer) > (2010-2013)

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1.
  • Crnalic, Sead, et al. (författare)
  • Early diagnosis and treatment is crucial for neurological recovery after surgery for metastatic spinal cord compression in prostate cancer
  • 2013
  • Ingår i: Acta Oncologica. - London : Informa Healthcare. - 0284-186X .- 1651-226X. ; 52:4, s. 809-815
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Background.</strong> Spinal cord compression is an oncological and surgical emergency. Delays in referral and diagnosis may influence functional outcome. It is therefore important to identify patients who will regain or maintain ability to walk after surgery. The aim of the present study was to examine current practice for referral and diagnosis of prostate cancer patients with spinal cord compression and to identify prognostic factors for neurological outcome after surgery.</p><p><strong>Patients and methods.</strong> The study includes<strong> </strong>68 consecutive patients with prostate cancer who underwent surgery due to neurological compromise.  Intervals from onset of neurological symptoms to referral, diagnosis, and treatment were analyzed in relation to functional outcome. The prognostic significance of preoperative clinical parameters on gait function one month after surgery was evaluated.</p><p><strong>Results.</strong> Patients who were referred from local hospitals had longer delay to surgery than those who directly presented to the cancer centre (p=0.004). The rate of diagnosis with MRI increased through the week and peaked on Friday, with few patients being diagnosed during weekends. Ability to walk before surgery, hormone-naive prostate cancer, and/or shorter time from loss of ambulation were associated with more favorable neurological outcome. In patients with hormone-refractory disease who were unable to walk before surgery regaining of ambulation was associated with: duration of paresis &lt;48 hours (p=0.005), good preoperative performance status (p=0.04), preoperative PSA serum level &lt;200 ng/ml (p=0.03), and surgery with posterior decompression and stabilization (p=0.03).</p><p><strong>Conclusion.</strong> Early diagnosis and rapid treatment of spinal cord compression in prostate cancer patients is crucial for neurological recovery. Rising of awareness for the condition among patients at risk and among physicians is mandatory as well as improvement of local and regional guidelines for treatment.</p>
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2.
  • Crnalic, Sead, et al. (författare)
  • Outcome after surgery for metastatic spinal cord compression in 54 patients with prostate cancer
  • 2012
  • Ingår i: Acta Orthopaedica. - Informa Healtcare. - 1745-3674 .- 1745-3682. ; 83:1, s. 80-86
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background and purpose The criteria for selecting patients who may benefit from surgery of spinal cord compression in metastatic prostate cancer are poorly defined. We therefore studied patients operated for metastatic spinal cord compression in order to evaluate outcome of surgery and to find predictors of survival. Patients and methods We reviewed the records of 54 consecutive patients with metastatic prostate cancer who were operated for spinal cord compression at Umeå University Hospital. The indication for surgery was neurological deficit due to spinal cord compression. 41 patients had hormone-refractory cancer and 13 patients had previously untreated, hormone-naïve prostate cancer. 29 patients were operated with posterior decompression only, and in 25 patients posterior decompression and stabilization was performed. Results Preoperatively, 6/54 of patients were able to walk. 1 month after surgery, 33 patients were walking, 15 were non-ambulatory, and 6 had died. Mortality rate was 11% at 1 month, 41% at 6 months, and 59% at 1 year. In the hormone-naïve group, 8/13 patients were still alive with a median postoperative follow-up of 26 months. In the hormone-refractory group, median survival was 5 months. Patients with hormone-refractory disease and Karnofsky performance status (KPS) of ≤ 60% had median survival of 2.5 months, whereas those with KPS of 70% and KPS of ≥ 80% had a median survival of 7 months and 18 months, respectively (p &lt; 0.001). Visceral metastases were present in 12/41 patients with hormone-refractory tumor at the time of spinal surgery, and their median survival was 4 months-as compared to 10 months in patients without visceral metastases (p = 0.003). Complications within 30 days of surgery occurred in 19/54 patients. Interpretation Our results indicate that patients with hormone-naive disease, and those with hormone-refractory disease with good performance status and lacking visceral metastases, may be helped by surgery for metastatic spinal cord compression.</p>
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3.
  • Crnalic, Sead, et al. (författare)
  • Predicting survival for surgery of metastatic spinal cord compression in prostate cancer : a new score
  • 2012
  • Ingår i: Spine. - 0362-2436 .- 1528-1159. ; 37:26, s. 2168-2176
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • <p><strong>Study design. </strong>We<strong> </strong>retrospectively analyzed prognostic factors for survival in prostate cancer patients operated for metastatic spinal cord compression.</p><p><strong>Objective. </strong>The aim was to obtain a clinical score for prediction of survival after surgery.</p><p><strong>Summary of background data. </strong>Survival prognosis is important when deciding about treatment of patients with metastatic spinal cord compression.<strong> </strong>The criteria for identifying prostate cancer patients who may benefit from surgical treatment are unclear.</p><p><strong>Patients and methods </strong>The study comprised<strong> </strong>68 consecutive patients with prostate cancer operated for metastatic spinal cord compression at Umeå University Hospital, Sweden. The indication for surgery was neurological deficit; 53 patients had hormone-refractory prostate cancer, and 15 patients had previously untreated, hormone-naïve prostate cancer. In 42 patients posterior decompression was performed and 26 patients were operated with posterior decompression and stabilization.</p><p><strong>Results </strong>A new score for prediction of survival was developed based on the results of survival analyses. The score includes: hormone status of prostate cancer, Karnofsky performance status, evidence of visceral metastasis, and preoperative serum PSA. The total scores ranged from 0 to 6. Three prognostic groups were formulated: group A (n = 32) with scores 0-1; group B (n = 23) with scores 2-4, and group C (n = 12) with scores 5-6. The median overall survival was 3 (0.3 - 20) months in group A, 16 (1.8 - 59) months in group B, and in group C more than half (7 of 12) of patients were still alive.</p><p><strong>Conclusion </strong>We present a new prognostic score for predicting survival of prostate cancer patients after surgery for metastatic spinal cord compression. The score is easy to apply in clinical practice and may be used as additional support when making decision about treatment.</p>
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