| 1. |
- Deloukas, Panos, et al.
(författare)
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Large-scale association analysis identifies new risk loci for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - 1061-4036. ; 45:1, s. 25-33
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Tidskriftsartikel (refereegranskat)abstract
- Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - Nature Publishing Group. - 1061-4036. ; 42:11, s. 937-U53
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
- Abdallah, J., et al.
(författare)
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Study of double-tagged gamma gamma events at LEPII
- 2006
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Ingår i: European physical journal C. - Springer. - 1434-6044. ; 46:3, s. 559-568
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Tidskriftsartikel (refereegranskat)abstract
- Double-tagged interactions of photons with virtualities Q(2) between 10 GeV2 and 200 GeV2 are studied with the data collected by DELPHI at LEPII from 1998 to 2000, corresponding to an integrated luminosity of 550 pb(-1). The gamma*gamma* -> mu(+)mu(-) data agree with QED predictions. The cross-section of the reaction gamma*gamma* -> hadrons is measured and compared to the LO and NLO BFKL calculations.
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| 4. |
- Heid, Iris M., et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
- 2010
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Ingår i: Nature genetics. - 1546-1718. ; 42:11, s. 949
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 x 10(-9) to P = 1.8 x 10(-40)) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 x 10(-3) to P = 1.2 x 10(-13)). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 5. |
- Abdallah et al., DELPHI Collaboration: J, et al.
(författare)
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A measurement of the tau hadronic branching ratios
- 2006
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Ingår i: European Physical Journal C. - 1434-6044. ; 46:1, s. 1-26
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Tidskriftsartikel (refereegranskat)abstract
- The exclusive and semi-exclusive branching ratios of the tau lepton hadronic decay modes (h(-)upsilon(tau), h(-)pi(0)upsilon(tau), h(-)pi(0)pi(0)upsilon(tau), h(-) >= 2 pi(0)nu(tau), 2h(-)h(+)upsilon(tau), 2h(-)h(+)>= 2 pi(0)upsilon(tau), 3h(-)2h(+)upsilon(tau) and 3h(-)2h(+) >= 1 pi(0)upsilon(tau)) were measured with data from the DELPHI detector at LEP.
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| 6. |
- Abdallah et al., DELPHI Collaboration: J, et al.
(författare)
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Investigation of colour reconnection in WW events with the DELPHI detector at LEP-2
- 2007
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Ingår i: European Physical Journal C. - EDP Sciences. - 1434-6044. ; 51:2, s. 249-269
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Tidskriftsartikel (refereegranskat)abstract
- In the reaction e(+)e(-) -> WW -> (q(1) (q) over bar (2))(q(3)(q) over bar (4)) the usual hadronization models treat the colour singlets q(1)(q) over bar (2) and q(3)(q) over bar (4) coming from two W bosons independently. However, since the. nal state partons may coexist in space and time, cross-talk between the two evolving hadronic systems may be possible during fragmentation through soft gluon exchange. This e. ect is known as colour reconnection. In this article the results of the investigation of colour reconnection e. ects in fully hadronic decays of W pairs in DELPHI at LEP are presented. Two complementary analyses were performed, studying the particle. ow between jets and W mass estimators, with negligible correlation between them, and the results were combined and compared to models. In the framework of the SK-I model, the value for its. parameter most compatible with the data was found to be: (SK)-S-kappa-I = 2.2(-1.3) (+2.5) corresponding to the probability of reconnection P-reco to be in the range 0.31 < P-reco < 0.68 at 68% confidence level with its best value at 0.52.
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| 7. |
- Abdallah, J., et al.
(författare)
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A determination of the centre-of-mass energy at LEP2 using radiative two-fermion events
- 2006
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Ingår i: European physical journal C. - Springer. - 1434-6044. ; 46:2, s. 295-305
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Tidskriftsartikel (refereegranskat)abstract
- Using e(+)e(-) -> mu(+)mu(-)(gamma) and e(+)e(-) -> q (q) over bar(gamma) events radiative to the Z pole, DELPHI has determined the centre-of-mass energy, root s, using energy and momentum constraint methods. The results are expressed as deviations from the nominal LEP centre-of-mass energy, measured using other techniques. The results are found to be compatible with the LEP Energy Working Group estimates for a combination of the 1997 to 2000 data sets.
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| 8. |
- Abdallah, J, et al.
(författare)
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A measurement of the branching fractions of the b-quark into charged and neutral b-hadrons
- 2003
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Ingår i: Physics Letters B. - Elsevier Science B.V.. - 0370-2693. ; 576:1-2, s. 29-42
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Tidskriftsartikel (refereegranskat)abstract
- The production fractions of charged and neutral b-hadrons in b-quark events from Z(0) decays have been measured with the DELPHI detector at LEP. An algorithm has been developed, based on a neural network, to estimate the charge of the weakly-decaying b-hadron by distinguishing its decay products from particles produced at the primary vertex. From the data taken in the years 1994 and 1995, the fraction of (b) over bar -quarks fragmenting into positively charged weakly-decaying b-hadrons has been measured to be: f(+) = (42.09+/-0.82(stat)+/-0.89(syst))%. Subtracting the rates for charged Xi(b)(+) and Omega(b)(+) baryons gives the production fraction of B+ mesons: f(Bu) = (40.99+/-0.82(stat)+/-1.11 (syst)) %.
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| 9. |
- Abdallah, J, et al.
(författare)
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A precise measurement of the B+, B-0 and mean b-hadron lifetime with the DELPHI detector at LEP I
- 2004
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Ingår i: The European Physical Journal C. - Springer. - 1434-6044. ; 33:3, s. 307-324
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Tidskriftsartikel (refereegranskat)abstract
- Final results from the DELPHI Collaboration on the lifetime of B+ and B-0 mesons and the mean b-hadron lifetime, are presented using the data collected at the Z(0) peak in 1994 and 1995. Elaborate, inclusive, secondary vertexing methods have been employed to ensure a b-hadron reconstruction with good efficiency. To separate samples of B+ and B-0 mesons, high performance neural network techniques are used that achieve very high purity signals. The results obtained are: tau(B+) = 1.624+/-0.014 (stat)+/-0.018 (syst) ps tau(B)0 = 1.531+/-0.021 (stat)+/-0.031 (syst) ps tau(B+)/tau(B)0 = 1.060+/-0.021 (stat)+/-0.024 (syst) and for the average b-hadron lifetime: taub/tau(B)0 = 1.570+/-0.005 (stat)+/-0.008 (syst) ps.
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| 10. |
- Abdallah, J, et al.
(författare)
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A precise measurement of the tau lifetime
- 2004
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Ingår i: The European Physical Journal. - Springer. - 1434-6044. ; 36:3, s. 283-296
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Tidskriftsartikel (refereegranskat)abstract
- The tau lepton lifetime has been measured with the e(+) e(-) --> tau(+) tau(-) events collected by the DELPHI detector at LEP in the years 1991 - 1995. Three different methods have been exploited, using both one-prong and three-prong tau decay channels. Two measurements have been made using events in which both taus decay to a single charged particle. Combining these measurements gave tau(tau) ( 1 prong) = 291.8 +/- 2.3(stat) +/- 1.5(sys) fs. A third measurement using taus which decayed to three charged particles yielded tau(tau) (3 prong) = 288.6 +/- 2.4(stat) +/- 1.3(sys) fs. These were combined with previous DELPHI results to measure the tau lifetime, using the full LEP1 data sample, to be tau(tau) = 290.9 +/- 1.4(stat) +/- 1.0(sys) fs.
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