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Sökning: WFRF:(Jonsson Pernilla)

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  • Jonsson, Pernilla Jonsson, 1967- (författare)
  • "Följ de omtänksamma husmödrarnas exempel" : livsmedelsannonsering i en svensk dagstidning, 1875-1965
  • 2009
  • Ingår i: Historisk Tidskrift (S). - 0345-469X. ; 2, s. 205-234
  • Tidskriftsartikel (refereegranskat)abstract
    • Handeln dominerade som annonsör under hela en studerade perioden. Märkesreklam i fabrikanters regi förekom redan 1875 och denna form av livsmedelannonsering var särskilt vanlig under 1920- och 1930-talen. Märkesvarorna var framför allt förpackade kolonialvaror samt nya processade varor där branschen präglades av oligopol och nya inbrytare. Fabrikanter, ofta utländska, var först med livsstilsannonsering. Under 1920- och 1930-talen befäste konsumentorienterad marknadsföring sin position i svensk dagstidningsreklam. Någonstans kring 1920 könades tilltalet i livsmedelsannonserna och riktades till framförallt kvinnor, definierade i en heterosexuell relation. Annonserna anspelade exempelvis på en önskan om en god hälsa eller att bli bekräftad som en lyckad hustru genom att tillfredställa man och barns önskningar. Men framförallt var det den goda husmoderns kunskap och förväntade önskan om att få hushållspengarna att räcka till som lyftes fram. Vid mitten av 1960-talet hade dock det suggestiva och normativa inslaget i livsmedelsannonserna minskat och varumärkesreklamen flyttats från dagstidningssidorna till veckotidningar och tidskrifter.
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3.
  • Chen, Yao, et al. (författare)
  • Thyroid hormone enhances nitric oxide mediated bacterial clearance and promotes survival after meningococcal infection
  • 2012
  • Ingår i: PLoS ONE. - 1932-6203. ; 7:7, s. e41445
  • Tidskriftsartikel (refereegranskat)abstract
    • Euthyroid sick syndrome characterized by reduced levels of thyroid hormones (THs) is observed in patients with meningococcal shock. It has been found that the level of THs reflects disease severity and is predictive for mortality. The present study was conducted to investigate the impact of THs on host defense during meningococcal infection. We found that supplementation of thyroxine to mice infected with Neisseria meningitidis enhanced bacterial clearance, attenuated the inflammatory responses and promoted survival. In vitro studies with macrophages revealed that THs enhanced bacteria-cell interaction and intracellular killing of meningococci by stimulating inducible nitric oxide synthase (iNos)-mediated NO production. TH treatment did not activate expression of TH receptors in macrophages. Instead, the observed TH-directed actions were mediated through nongenomic pathways involving the protein kinases PI3K and ERK1/2 and initiated at the membrane receptor integrin alpha v beta 3. Inhibition of nongenomic TH signaling prevented iNos induction, NO production and subsequent intracellular bacterial killing by macrophages. These data demonstrate a beneficial role of THs in macrophage-mediated N. meningitidis clearance. TH replacement might be a novel option to control meningococcal septicemia.
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6.
  • Eliasson, Pernilla, et al. (författare)
  • Hypoxia mediates low cell-cycle activity and increases the proportion of long-term reconstituting hematopoietic stem cells during in vitro culture
  • 2010
  • Ingår i: EXPERIMENTAL HEMATOLOGY. - 0301-472X. ; 38:4, s. 301-310
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. Recent evidence suggests that hematopoietic stem cells (HSCs) in the bone marrow (BM) are located in areas where the environment is hypoxic. Although previous studies have demonstrated positive effects by hypoxia, its role in HSC maintenance has not been fully elucidated, neither has the molecular mechanisms been delineated. Here, we have investigated the consequence of in vitro incubation of HSCs in hypoxia prior to transplantation and analyzed the role of hypoxia-inducible factor (HIF)-1 alpha. Materials and Methods. HSC and progenitor populations isolated from mouse BM were cultured in 20% or 1% O-2, and analyzed for effects on cell cycle, expression of cyclin-dependent kinase inhibitors genes, and reconstituting ability to lethally irradiated mice. The involvement of HIF-1 alpha was studied using methods of protein stabilization and gene silencing. Results. When long-term FLT3(-)CD34(-)Lin(-)Sca-1(+)c-Kit(+) (LSK) cells were cultured in hypoxia, cell numbers were significantly reduced in comparison to normoxia. This was due to a decrease in proliferation and more cells accumulating in G(0). Moreover, the proportion of HSCs with long-term engraftment potential was increased. Whereas expression of the cyclin-dependent kinase inhibitor genes p21(cip1), p27(Kip1), and p57(Kip2) increased in LSK cells by hypoxia, only p21(cip1) was upregulated in FLT3(-)CD34(-)LSK cells. We could demonstrate that expression of p27(KiP1) and p57(Kip2) was dependent of HIF-1 alpha. Surprisingly, overexpression of constitutively active HIF-1 alpha or treatment with the HIF stabilizer agent FG-4497 led to a reduction in HSC reconstituting ability. Conclusions. Our results imply that hypoxia, in part via HIF-1 alpha, maintains HSCs by decreasing proliferation and favoring quiescence.
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  • Hedenrud, Tove, 1967-, et al. (författare)
  • Beliefs about medicines and adherence among Swedish migraineurs.
  • 2007
  • Ingår i: The 13th Congress of the International Headache Society, Stockholm, juni 2007..
  • Konferensbidrag (refereegranskat)abstract
    • Objective The aim was to analyze whether beliefs about medicines are associated with adherence to prophylactic medication among Swedish migraineurs. Methods A questionnaire was distributed consecutively to migraineurs attending a tertiary clinic. All participants were prescribed prophylactic medication. The questionnaire comprised e.g. background questions, beliefs about medicines (BMQ), and self-reported adherence (MARS). The General BMQ comprises three subparts: General Harm, General Overuse, and General Benefit. The specific part of the BMQ has two subparts: Specific Necessity and Specific Concerns. For the BMQ Specific, a necessity–concerns differential was calculated for each participant. A logistic regression analysis was performed to analyze the association between beliefs about medicines and adherence to prophylactic medication. Results Of the 175 participants, 15% were male and more than half of the participants were aged 45 years and over. Fifty percent had a university degree. Sixty-four percent were considered adherent. There was no significant difference in adherence between gender, age groups, or by educational level. Respondents with only compulsory school were less concerned about the long-term effects of medications and had a higher necessity–concern differential. In the logistic regression analysis, no variable was significantly associated with adherence. Conclusions The present study showed no association between beliefs about medication and adherence. We recommend that lack of adherence to migraine prophylactic drugs should be considered more often, looked for, and addressed in order to identify sufferers with an unnecessarily high migraine-associated disability. This assumes greater attention to the problem amongst both physicians and researchers in all countries.
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10.
  • Hedenrud, Tove, 1967-, et al. (författare)
  • Medication Overuse Headache: Self-Perceived and Actual Knowledge Among Pharmacy Staff
  • 2014
  • Ingår i: Headache. - 0017-8748. ; 54:6, s. 1019-1025
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective The aim of this study was to investigate knowledge about medication overuse headache (MOH) among pharmacy staff. Background MOH is a public health problem both in Sweden and in many other countries. Persons with MOH have limited contact with health care, and medications used are to large extent over-the-counter (OTC) medications. Therefore, pharmacists have an important role in, eg, advising these individuals about their medication use. Little is, however, known about the actual level of knowledge about MOH among pharmacy staff, which determines the quality of their advice to MOH sufferers. Methods A total of 326 questionnaires were distributed to 44 pharmacies in Gothenburg, Sweden. The questionnaire included background questions, questions about advice on headache treatment, source of knowledge about MOH, and questions on self-perceived and actual knowledge on MOH. Results The response rate was 70%. A majority of the pharmacy staff (90.6%) considered themselves to have knowledge about MOH to some or a greater extent. Almost half had learned about MOH through their university/vocational education. Only 8.6% knew that all 5 headache medications listed in the questionnaire can cause development of MOH, but 40% responded correctly on which treatment advice one can give a person with MOH. Actual knowledge on treatment advice differed significantly between groups of self-perceived knowledge. Conclusion The knowledge on MOH is insufficient among pharmacy staff, but with the proper knowledge, pharmacy staff is well positioned to effect both primary and secondary prevention of MOH. We suggest not only increasing educational efforts about MOH within pharmacy programs but also continuing education at the pharmacies for all staff. Further, it is also important to increase knowledge among pharmacy customers.
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