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Träfflista för sökning "WFRF:(Kerstin Sundberg) "

Sökning: WFRF:(Kerstin Sundberg)

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2.
  • Ahlgren, Kerstin. M, et al. (författare)
  • Diabetes mellitus in dog - : No evidence for a type-1-like phenotype
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  • Annan publikation (övrigt vetenskapligt)abstract
    • Aims/hypothesisDiabetes mellitus (DM) is one of the most common endocrine disorders in dogs, and is commonly proposed to be of autoimmune origin. Although the clinical symptoms of human type 1 diabetes (T1D) and canine DM are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported.Methods Sera from 121 diabetic dogs representing 38 different breeds were tested for islet cell antibodies (ICA) and GAD65 autoantibodies (GADA) and compared with sera from 133 healthy dogs from 40 breeds. ICA was detected by indirect immunofluorescence using both canine and human frozen sections. GADA was detected by in vitro transcription and translation (ITT) of human and canine GAD65, followed by immunoprecipitation.ResultsNone of the canine sera analyzed tested positive for ICA on sections of frozen canine or human ICA pancreas. However, serum from one diabetic dog was weakly positive in the canine GADA assay and serum from one healthy dog was weakly positive in the human GADA assay.Conclusions/interpretationsBased on sera from 121 diabetic dogs from 38 different breeds were tested for humoral autoreactivity using four different assays, contrary to previous observations, we find no support for an autoimmune aetiology  in canine diabetes.
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3.
  • Ahlgren, Kerstin M, et al. (författare)
  • Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus.
  • 2014
  • Ingår i: PloS one. - 1932-6203. ; 9:8, s. e105473
  • Tidskriftsartikel (refereegranskat)abstract
    • Diabetes mellitus is one of the most common endocrine disorders in dogs and is commonly proposed to be of autoimmune origin. Although the clinical presentation of human type 1 diabetes (T1D) and canine diabetes are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported.
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4.
  • Ahlgren, Kerstin, M., et al. (författare)
  • Type I Interferon signature in Nova Scotia duck tolling retriever dogs with steroid responsive meningitis-arteritis
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  • Annan publikation (övrigt vetenskapligt)abstract
    • Objective: Dogs of the breed Nova Scotia duck tolling retriever (NSDTR) are prone to develop a disease complex in some aspects resembling human systemic lupus erythematosus (SLE). Peripheral blood mononuclear cells (PBMCs) from human SLE patients have an increased mRNA expression type I interferon (IFN) regulated genes. However, it is unknown whether diseased dogs also display the typical type I IFN signature.Methods: To test canine sera for their capacity to induce type I IFN response Mardin-Darby canine kidney (MDCK) cells were cultured with sera from healthy dogs (n=25),  immune-mediated rheumatic disease (IMRD) dogs with anti-nuclear antibodies (ANA+) (n=30) or dogs with steroid responsive meningitis-arteritis (SRMA) (n=25). mRNA expression of the genes MX1, IFIT1 and CXCL10 was measured by quantitative Real Time PCR.Results: A highly significant (p=0.0009) increase in mRNA expression of the type I IFN responsive gene MX1 was detected in cells stimulated by sera from dogs with SRMA, but not from IMRD ANA+ dogs. Expression of IFIT1 was twice as high in cells stimulated by sera from dogs with SRMA compared to both healthy dogs and ANA+ dogs. The mean expression of CXCL10 was nearly ten times higher in cells stimulated by sera from SRMA dogs than by ANA+ dogs and four times higher compared to cells stimulated by control dogs.Conclusion: Presence of type I IFN in sera from diseased NSDTR dogs was found in this study. This implies that this canine model can be used for identification of pathways of importance for autoimmune disorders in humans and for testing of novel therapeutic approaches. Our results can also be a step on the way towards personalized drugs in these dogs.
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6.
  • Olsson, Mia, et al. (författare)
  • The dog as a genetic model for immunoglobulin A (IgA) deficiency : Identification of several breeds with low serum IgA concentrations
  • 2014
  • Ingår i: Veterinary Immunology and Immunopathology. - 0165-2427. ; 60:3-4, s. 255-259
  • Tidskriftsartikel (refereegranskat)abstract
    • Immunoglobulin A (IgA) serves as the basis of the secretory immune system by protecting the lining of mucosal sites from pathogens. In both humans and dogs, IgA deficiency (IgAD) is associated with recurrent infections of mucosal sites and immune-mediated diseases. Low concentrations of serum IgA have previously been reported to occur in a number of dog breeds but no generally accepted cut-off value has been established for canine IgAD. The current study represents the largest screening to date of IgA in dogs in terms of both number of dogs (n = 1267) and number of breeds studied (n = 22). Serum IgA concentrations were quantified by using capture ELISA and were found to vary widely between breeds. We also found IgA to be positively correlated with age (p < 0.0001). Apart from the two breeds previously reported as predisposed to low IgA (Shar-Pei and German shepherd), we identified six additional breeds in which > 10% of all tested dogs had very low (<0.07 g/l) IgA concentrations (Hovawart, Norwegian elkhound, Nova Scotia duck tolling retriever, Bullterrier, Golden retriever and Labrador retriever). In addition, we discovered low IgA concentrations to be significantly associated with canine atopic dermatitis (CAD, p < 0.0001) and pancreatic acinar atrophy (PAA, p = 0.04) in German shepherds.
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8.
  • Cabak Rédei, Anna, et al. (författare)
  • József Eötvös and the age of Hungarian reform
  • 2004
  • Ingår i: Modernisation and tradition. European local and manorial societies 1500-1900.. - Nordic academic press.
  • Bokkapitel (övrigt vetenskapligt)abstract
    • The question at stake is to what extent could the Hungarian intelligentsia, here foremost represented by the author and political thinker József Eötvös, in the beginning of the 19th century, take in the ideas of the Enlightment and its notion of equality. By studying Eötvös' highly political novel "Village Notary" some conclusions are made regarding how Rousseau's political philosophy was understood in the Hungarian cultural and social context.
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9.
  • Cederholm, Mathias, et al. (författare)
  • From protection to privileges - forsvar and herligheder : concept analysis as social history, Denmark-Scania 1450-1650
  • 2004
  • Ingår i: Modernisation and tradition : European local and manorial societies 1500-1900. - Nordic Academic Press. - 91-89116-40-2 ; s. 25-47
  • Bokkapitel (övrigt vetenskapligt)abstract
    • This is a study of the Danish nobility in the period 1450-1650. The aim is to show the changes in the socio-economic foundations of this group under advance during the period, and how this corresponded with changes in the methods and articulations which were used to create legitimicy för the nobility and its' resource claims. Among else we can see that the discourse supposed to ground the legitimacy of the Estate changed from a stress on the nobility as a group of protectors of their subjects to an increasing understanding of the nobility as an Estate of owners of private property. The idea of noble private property was at the same time to a large degree guaranteed by royal privileges, which complicates our understanding of the development of the idea of property.
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10.
  • Cederholm, Mathias, et al. (författare)
  • Konsten att hävda en skog : bönder och herrar i senmedeltida skogskonflikter i Skåne
  • 2006
  • Ingår i: Gods och bönder från högmedeltid till nutid : kontinuitet genom omvandling på Vittskövle och andra skånska gods. - Nordic Academic Press. - 978-91-89116-59-7 ; s. 317-361
  • Bokkapitel (övrigt vetenskapligt)abstract
    • In this article the author examines varieties of resource-conflicts between peasants and lords regarding woods and forests in Scania, Denmark, during the late 15th and early 16th centuries. Important results are among others that the wood resource was very disputed this period due to an increasing population pressure as well as an expansive landed aristocracy. The patterns of conflict were often complex, involving cooperation between peasants and lords on both sides. The conflicts also illustrate the different actions peasants could choose in social conflicts, with legal negotiations, risings, political negotiations and some times royal privileges and legislation.
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  • Resultat 1-10 av 32
  • [1]234Nästa
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Sundberg, Kerstin (15)
Olsson, Mats (7)
Lundh, Christer (6)
Skansjö, Sten (6)
Lindblad-Toh, Kersti ... (5)
Sundberg, Katarina (5)
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Andersson, Göran (4)
Åkerman, Gun, (4)
Hansson-Hamlin, Hele ... (4)
Sundberg, Henrik (4)
Grunder, Kerstin (4)
Ahlgren, Kerstin. M, (3)
Fall, Tove (3)
Lobell, Anna (3)
Kämpe, Olle (3)
Tjärnlund, Ulla (3)
Balk, Lennart (3)
Hansen, Kjell, (3)
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Lernmark, Åke (2)
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Landegren, Nils (2)
von Euler, Henrik (2)
Hedhammar, Åke (2)
Hedhammar, Ake (2)
Wilbe, Maria (2)
Balaz, Martina, (2)
Kerstin, Sundberg (2)
Leijon, Mats, (2)
Sundberg, Mark, (2)
Broman, Dag, (2)
Bergman, Karl (2)
Thorburn, Karin, (2)
Sundberg, Jan, (2)
Tågerud, Sven, (2)
Bunk, R (2)
Omling, P (2)
Montelius, L (2)
Frölander, Kerstin (2)
Cederholm, Mathias (2)
Danielsson, Oskar, (2)
Strand, Kerstin (2)
Ericsson, Ellerth (2)
Lindahl, Joakim (2)
Ishaq, Rasha (2)
Eriksson, Mikael, (1)
Svensson, Patrick (1)
Breitholtz, Magnus, (1)
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