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Träfflista för sökning "WFRF:(Landen M) ;srt2:(2010-2014)"

Sökning: WFRF:(Landen M) > (2010-2014)

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41.
  • Jonsson, Lina, et al. (författare)
  • Mutation screening of melatonin-related genes in patients with autism spectrum disorders.
  • 2010
  • Ingår i: BMC medical genomics. - 1755-8794. ; 3
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: One consistent finding in autism spectrum disorders (ASD) is a decreased level of the pineal gland hormone melatonin and it has recently been demonstrated that this decrease to a large extent is due to low activity of the acetylserotonin O-methyltransferase (ASMT), the last enzyme in the melatonin synthesis pathway. Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene. METHODS: In the present study, we have investigated all the genes involved in the melatonin pathway by mutation screening of AA-NAT (arylalkylamine N-acetyltransferase), ASMT, MTNR1A, MTNR1B (melatonin receptor 1A and 1B) and GPR50 (G protein-coupled receptor 50), encoding both synthesis enzymes and the three main receptors of melatonin, in 109 patients with autism spectrum disorders (ASD). A cohort of 188 subjects from the general population was used as a comparison group and was genotyped for the variants identified in the patient sample. RESULTS: Several rare variants were identified in patients with ASD, including the previously reported splice site mutation in ASMT (IVS5+2T>C). Of the variants affecting protein sequence, only the V124I in the MTNR1B gene was absent in our comparison group. However, mutations were found in upstream regulatory regions in three of the genes investigated, ASMT, MTNR1A, and MTNR1B. CONCLUSIONS: Our report of another ASD patient carrying the splice site mutation IVS5+2T>C, in ASMT further supports an involvement of this gene in autism. Moreover, our results also suggest that other melatonin related genes might be interesting candidates for further investigation in the search for genes involved in autism spectrum disorders and related neurobehavioral phenotypes. However, further studies of the novel variants identified in this study are warranted to shed light on their potential role in the pathophysiology of these disorders.
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42.
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43.
  • Kyaga, S, et al. (författare)
  • Bipolar disorder and leadership
  • 2014
  • Ingår i: BIPOLAR DISORDERS. - 1398-5647. ; 16, s. 107-107
  • Konferensbidrag (övrigt vetenskapligt)
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44.
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45.
  • Kyaga, Simon, et al. (författare)
  • Creativity and mental disorder: family study of 300 000 people with severe mental disorder.
  • 2011
  • Ingår i: The British journal of psychiatry : the journal of mental science. - 1472-1465. ; 199:5, s. 373-379
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: There is a long-standing belief that creativity is coupled with psychopathology. AIMS: To test this alleged association and to investigate whether any such association is the result of environmental or genetic factors. METHOD: We performed a nested case-control study based on Swedish registries. The likelihood of holding a creative occupation in individuals who had received in-patient treatment for schizophrenia, bipolar disorder or unipolar depression between 1973 and 2003 and their relatives without such a diagnosis was compared with that of controls. RESULTS: Individuals with bipolar disorder and healthy siblings of people with schizophrenia or bipolar disorder were overrepresented in creative professions. People with schizophrenia had no increased rate of overall creative professions compared with controls, but an increased rate in the subgroup of artistic occupations. Neither individuals with unipolar depression nor their siblings differed from controls regarding creative professions. CONCLUSIONS: A familial cosegregation of both schizophrenia and bipolar disorder with creativity is suggested.
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46.
  • Larsson, Henrik, 1975-, et al. (författare)
  • Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder.
  • 2013
  • Ingår i: The British journal of psychiatry : the journal of mental science. - 1472-1465. ; 203:2, s. 103-6
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is associated with bipolar disorder and schizophrenia, and it has been suggested that combined bipolar disorder and ADHD is aetiologically distinct from the pure disorders.AIMS: To clarify whether ADHD shares genetic and environmental factors with bipolar disorder and schizophrenia.METHOD: By linking longitudinal Swedish national registers, we identified 61 187 persons with ADHD (the proband group) and their first- and second-degree relatives, and matched them with a control group of people without ADHD and their corresponding relatives. Conditional logistic regression was used to determine the risks of bipolar disorder and schizophrenia in the relatives of the two groups.RESULTS: First-degree relatives of the ADHD proband group were at increased risk of both bipolar disorder (odds ratio (OR) = 1.84-2.54 for parents, offspring and full siblings) and schizophrenia (OR = 1.71-2.22 for parents, offspring and full siblings). The risks of bipolar disorder and schizophrenia among second-degree relatives were substantially lower than among full siblings.CONCLUSIONS: These findings suggest that the co-occurrence of ADHD and bipolar disorder as well as ADHD and schizophrenia is due to shared genetic factors, rather than representing completely aetiologically distinct subsyndromes.
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47.
  • Liberg, Benny, et al. (författare)
  • Motor imagery in bipolar depression with slowed movement.
  • 2013
  • Ingår i: The Journal of nervous and mental disease. - 1539-736X. ; 201:10, s. 885-93
  • Tidskriftsartikel (refereegranskat)abstract
    • We hypothesized that motor retardation in bipolar depression is mediated by disruption of the pre-executive stages of motor production. We used functional magnetic resonance imaging to investigate neural activity during motor imagery and motor execution to elucidate whether brain regions that mediate planning, preparation, and control of movement are activated differently in subjects with bipolar depression (n = 9) compared with healthy controls (n = 12). We found significant between-group differences. During motor imagery, the patients activated the posterior medial parietal cortex, the posterior cingulate cortex, the premotor cortex, the prefrontal cortex, and the frontal poles more than the controls did. Activation in the brain areas involved in motor selection, planning, and preparation was altered. In addition, limbic and prefrontal regions associated with self-reference and the default mode network were altered during motor imagery in bipolar depression with motor retardation.
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48.
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49.
  • Lundh, Anna, et al. (författare)
  • A Comparison of Seminar and Computer Based Training on the Accuracy and Reliability of Raters Using the Children's Global Assessment Scale (CGAS).
  • 2012
  • Ingår i: Administration and policy in mental health. - 1573-3289. ; 39:6, s. 458-465
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to compare two methods to conduct CGAS rater training. A total of 648 raters were randomized to training (CD or seminar), and rated five cases before and 12 months after training. The ICC at baseline/end of study was 0.71/0.78 (seminar), 0.76/0.78 (CD), and 0.67/0.79 (comparison). There were no differences in training effect in terms of agreement with expert ratings, which speaks in favor of using the less resource-demanding CD. However, the effect was modest in both groups, and untrained comparison group improved of the same order of magnitude, which proposes more extensive training.
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50.
  • Lundh, Anna, et al. (författare)
  • Children's Global Assessment Scale (CGAS) in a naturalistic clinical setting: Inter-rater reliability and comparison with expert ratings.
  • 2010
  • Ingår i: Psychiatry research. - 0165-1781. ; 177:1-2, s. 206-210
  • Tidskriftsartikel (refereegranskat)abstract
    • The Children's Global Assessment Scale (CGAS) is a tool to assess the overall level of functioning of children in Child and Adolescent Mental Health Services (CAMHS). Even though the use of this rating scale requires trained raters, it is commonly deployed without prior training in clinical settings. The aim of this study was to investigate the reliability and the agreement of CGAS ratings with an expert rating, in a clinical setting with untrained raters. Five experienced clinicians rated five vignettes to provide expert ratings. These vignettes were then rated by 703 health-care professionals representing 33 Swedish CAMHS. The health-care professionals rated the vignettes significantly higher (showing better global functioning) than the expert ratings. There was a wide range between the minimum and maximum ratings. The intraclass correlation coefficient was 0.73, which indicates moderate inter-rater reliability. Neither clinical experience nor earlier experience of using CGAS influenced the agreement with the expert ratings. The inter-rater reliability is moderate when CGAS is used in a clinical setting with untrained raters. Further, the untrained raters differed substantially from the experts. This stresses the importance of proper training in conjunction with the introduction of new rating scales.
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  • Resultat 41-50 av 87
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