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  • Machold, Robert, et al. (författare)
  • Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
  • 2003
  • Ingår i: Neuron. ; 39:6, s. 937-950
  • Tidskriftsartikel (refereegranskat)abstract
    • To directly test the requirement for hedgehog signaling in the telencephalon from early neurogenesis, we examined conditional null alleles of both the Sonic hedgehog and Smoothened genes. While the removal of Shh signaling in these animals resulted in only minor patterning abnormalities, the number of neural progenitors in both the postnatal subventricular zone and hippocampus was dramatically reduced. In the subventricular zone, this was partially attributable to a marked increase in programmed cell death. Consistent with Hedgehog signaling being required for the maintenance of stem cell niches in the adult brain, progenitors from the subventricular zone of floxed Smo animals formed significantly fewer neurospheres. The loss of hedgehog signaling also resulted in abnormalities in the dentate gyrus and olfactory bulb. Furthermore, stimulation of the hedgehog pathway in the mature brain resulted in elevated proliferation in telencephalic progenitors. These results suggest that hedgehog signaling is required to maintain progenitor cells in the postnatal telencephalon.
  • Swindlehurst, Andrew Lee, et al. (författare)
  • Application of MUSIC to Arrays with Multiple Invariances
  • 2000
  • Ingår i: Proceedings IEEE International Conference on Acoustics, Speech, and Signal Processing. - IEEE. ; s. 3057-3060
  • Konferensbidrag (refereegranskat)abstract
    • This paper describes generalizations of the MUSIC and root-MUSIC algorithms for direction of arrival (DOA) estimation to arrays composed of multiple translated subarrays. The advantage of these new approaches is that the DOAs can be estimated using either a one-dimensional search or by rooting a polynomial, as opposed to a multidimensional search as required by the multiple invariance (MI)-ESPRIT algorithm. While MI-MUSIC and root-MI-MUSIC are not statistically efficient like MI-ESPRIT, they do perform better than a single invariance implementation of ESPRIT, and are thus better suited for finding the initial conditions required by the MI-ESPRIT search.
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