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Träfflista för sökning "WFRF:(Li Jingmei) srt2:(2013)"

Sökning: WFRF:(Li Jingmei) > (2013)

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1.
  • Bojesen, Stig E., et al. (författare)
  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
  • 2013
  • Ingår i: Nature Genetics. - Nature Publishing Group. - 1546-1718. ; 45:4, s. 371-384
  • Tidskriftsartikel (refereegranskat)abstract
    • TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOG, we analyzed similar to 480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 x 10(-7)), lower risks for estrogen receptor (ER)-negative (P = 1.0 x 10(-8)) and BRCA1 mutation carrier (P = 1.1 x 10(-5)) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 x 10(-14)), higher risk of low-malignant-potential ovarian cancer (P = 1.3 x 10(-15)) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 x 10(-12)) and BRCA1 mutation carrier (P = 1.6 x 10-14) breast and invasive ovarian (P = 1.3 x 10(-11)) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.
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2.
  • Hu, Han, et al. (författare)
  • Severe Traffic Crash Speaks Safety Facts From Mountain Roads in China
  • 2013
  • Ingår i: Proceedings of the 16th International Conference Road Safety on Four Continents : Beijing, China. 15-17 May 2013. - Linköping : Statens väg- och transportforskningsinstitut.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • objective to build up a systematic mountain road safety enhancement technology, this study analyses severe traffic crashes from 2006 to 2010 occurred on an inter-regional mountain arterial road network in south China. In order to digest these crash data collected from local traffic police stations, the authors conduct the in-depth crash analysis from the aspect of human, vehicle, road, and management. By developing the definition sets for crash deterministic causing factors judging system, the deterministic causes of severe accidents on mountain roads in China are deeply investigated. Results of our analysis indicate that human factor does weigh the most in the occurrence of the severe crashes; main crash types on mountain roads are running-off road, headon collision, overturned; Almost 76% severe crashes occurred on slope/curve combination sites; and freight car shall be given more attentions in reducing the severe accidents.
3.
  • Hu, Jingmei, et al. (författare)
  • Speed Control Effect Study on Optical Illusion Deceleration Markings
  • 2013
  • Ingår i: Proceedings of the 16th International Conference Road Safety on Four Continents : Beijing, China. 15-17 May 2013. - Linköping : Statens väg- och transportforskningsinstitut.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • The optical illusion deceleration marking is one of the commonly used speed control measures. In this research, the authors analyzed operating speed and trajectory of motor vehicle at intersection where optical illusion deceleration marking is installed. Quantitative and qualitative evaluation on effect of optical illusion deceleration marking is conducted. Results showed that optical illusion deceleration marking would help to reduce operating speed and average speed by 5-10km/h, to regulate motorcycle driver behavior, and to reduce speed difference, so that driving safety is ensured. Optical illusion deceleration marking is suitable for accident prone road sections on two-lane highways which main vehicle types are passenger car and motorcycle.
4.
  • Li, Jinhai, et al. (författare)
  • Effects of Roadway Segment Alignments and Locations on Rural Two-Lane Highway Crash Rates
  • 2013
  • Ingår i: Proceedings of the 16th International Conference Road Safety on Four Continents : Beijing, China. 15-17 May 2013. - Linköping : Statens väg- och transportforskningsinstitut.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • This paper investigates the effects of road segment alignment and location on rural two-lane highway crash rates by taking the mileage of segment types into consideration. Roadway segments are classified and redefined according to the segment alignment and location. The definitions of crash rates in terms of segment alignment and location are presented respectively. The study gathers crash data and the roadway geometric information of rural two-lane highways in southwest of China and crash rates of each segment type are proposed by utilizing the proposed definitions. The result indicates that gentle-slope & sharp-curve segments and intersections tend to have extremely higher crash rates than the other types of segments.
5.
  • Meyer, Kerstin B., et al. (författare)
  • Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1
  • 2013
  • Ingår i: American Journal of Human Genetics. - Cell Press. - 0002-9297. ; 93:6, s. 1046-1060
  • Tidskriftsartikel (refereegranskat)abstract
    • The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ER alpha to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of FGFR2, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the FGFR2 risk locus primarily predisposes to estrogen-receptor-positive disease.
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6.
  • Rietveld, Cornelius A., et al. (författare)
  • GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
  • 2013
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 340:6139, s. 1467-1471
  • Tidskriftsartikel (refereegranskat)abstract
    • A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R-2 approximate to 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximate to 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
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7.
  • Sandberg, Maria E. C., et al. (författare)
  • Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study
  • 2013
  • Ingår i: Breast Cancer Research. - BioMed Central. - 1465-5411. ; 15:4, s. 1-9
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.RESULTS: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).CONCLUSION: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.
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