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Sökning: WFRF:(Ljunggren Magnus 1942 )

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1.
  • Johansson, Helena, et al. (författare)
  • High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden.
  • 2012
  • Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 1523-4681. ; 27:6, s. 1390-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 elderly men drawn from the general population and recruited to the Osteoporotic Fractures in Men (MrOS) study in Gothenburg, Sweden. Baseline data included general health questionnaires, lifestyle questionnaires, body mass index (BMI), bone mineral density (BMD), serum adiponectin, osteocalcin, and leptin. Men were followed for up to 7.4 years (average, 5.2 years). Poisson regression was used to investigate the relationship between serum adiponectin, other risk variables and the time-to-event hazard function of fracture. Median levels of serum adiponectin at baseline were 10.4 mu g/mL (interquartile range, 7.714.3). During follow-up, 150 men sustained one or more fractures. The risk of fracture increased in parallel with increasing serum adiponectin (hazard ratio HR/SD, 1.46; 95% confidence interval CI, 1.231.72) and persisted after multivariate-adjusted analysis (HR/SD, 1.30; 95% CI, 1.091.55). Serum adiponectin shows graded stepwise association with a significant excess risk of fracture in elderly men that was independent of several other risk factors for fracture. Its measurement holds promise as a risk factor for fracture in men. (C) 2012 American Society for Bone and Mineral Research.
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2.
  • Johansson, Helena, 1981-, et al. (författare)
  • Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden.
  • 2011
  • Ingår i: Osteoporosis international. - 1433-2965. ; 22:5, s. 1411-1418
  • Tidskriftsartikel (refereegranskat)abstract
    • We studied the nature of the relationship between bone mineral density (BMD) and the risk of death among elderly men. BMD was associated with mortality risk and was independent of adjustments for other co-morbidities. A piecewise linear function described the relationship more accurately than assuming the same gradient of risk over the whole range of BMD (p = 0.020). Low BMD was associated with a substantial excess risk of death, whilst a higher than average BMD had little impact on mortality. Previous studies have demonstrated an association between low BMD and an increased risk of death among men and women. The aim of the present study was to examine the pattern of the risk in men and its relation to co-morbidities. We studied the nature of the relationship between BMD and death among 3,014 elderly men drawn from the population and recruited to the MrOS study in Sweden. Baseline data included general health questionnaires, life style questionnaires and BMD measured using DXA. Men were followed for up to 6.5 years (average 4.5 years). Poisson regression was used to investigate the relationship between BMD, co-morbidities and the hazard function of death. During follow-up, 382 men died (all-cause mortality). Low BMD at all measured skeletal sites was associated with increased mortality. In multivariate analyses, the relationship between BMD and mortality was non-linear, and a piecewise linear function described the relationship more accurately than assuming the same gradient of risk over the whole range of BMD (p = 0.020). Low BMD is associated with a substantial excess risk of death compared to an average BMD, whereas a higher than average BMD has a more modest effect on mortality. These findings, if confirmed elsewhere, have implications for the constructing of probability-based fracture risk assessment tools.
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3.
  • Mellström, Dan, 1945-, et al. (författare)
  • Older men with low serum estradiol and high serum SHBG have an increased risk of fractures.
  • 2008
  • Ingår i: Journal of bone and mineral research. - 1523-4681. ; 23:10, s. 1552-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Osteoporosis-related fractures constitute a major health concern not only in women but also in men. To study the predictive role of serum sex steroids for fracture risk in men, serum sex steroids were analyzed by the specific gas chromatography-mass-spectrometry technique at baseline in older men (n = 2639; mean, 75 yr of age) of the prospective population-based MrOS Sweden cohort. Fractures occurring after baseline were validated (average follow-up of 3.3 yr). The incidence for having at least one validated fracture after baseline was 20.9/1000 person-years. Estradiol (E2; hazard ratio HR per SD decrease, 1.34; 95% CI, 1.22-1.49), free estradiol (fE2; HR per SD decrease, 1.41; 95% CI, 1.28-1.55), testosterone (T; HR per SD decrease, 1.27;95% CI, 1.16-1.39), and free testosterone (fT; HR per SD decrease, 1.32; 95% CI, 1.21-1.44) were all inversely, whereas sex hormone-binding globulin (SHBG; HR per SD increase, 1.41; 95% CI, 1.22-1.63) was directly related to fracture risk. Multivariable proporitional hazards regression models, adjusted for age, suggested that fE2 and SHBG (p < 0.001), but not fT, were independently associated with fracture risk. Further subanalyses of fracture type showed that fE2 was inversely associated with clinical vertebral fractures (HR per SD decrease, 1.57% CI, 1.36-1.80), nonvertebral osteoporosis fractures (HR per SD decrease, 1.42; 95% CI, 1.23-1.65), and hip fractures (HR per SD decrease, 1.44; 95% CI, 1.18-1.76). The inverse relation between serum E2 and fracture risk and nonlinear with a strong relation <16 pg/ml for E2 and 0.3 pg/ml for fE2. In conclusion, older Swedish men with low serum E2 and high SHBG levels have an increased risk of fractures.
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4.
  • Ljunggren, Magnus, 1942- (författare)
  • An Unknown Drawing By Ivan Turgenev
  • 2013
  • Ingår i: Toronto Slavic Quarterly. - 1925-2978. ; :43, s. 203-205
  • Tidskriftsartikel (övrigt vetenskapligt)
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5.
  • Ljunggren, Magnus, 1942- (författare)
  • Andrej Belyj i Sergej Solov´ev
  • 2005
  • Ingår i: Vladimir Solov´ev i kul´tura Serebrjanogo veka. - Nauka. - 5-02-033545-2 ; s. 288-295
  • Bokkapitel (övrigt vetenskapligt)
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6.
  • Ljunggren, Magnus, 1942- (författare)
  • Andrej Belyj och universitetet
  • 2009
  • Ingår i: Psykoanalytisk Tid/Skrift. ; :26-27
  • Tidskriftsartikel (populärvet., debatt m.m.)
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7.
8.
  • Ljunggren, Magnus, 1942- (författare)
  • Asta Wickman
  • 2011
  • Ingår i: Svenskt översättarlexikon http://oversattarlexikon.se/artiklar/asta_wickman.
  • Tidskriftsartikel (populärvet., debatt m.m.)
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9.
  •  
10.
  • Ljunggren, Magnus, 1942- (författare)
  • Axel Key, idealist och idunes
  • 2012
  • Ingår i: Idun 150 år. En jubileumsantologi. - Stockholm : Sällskapet Idun. - 9789163707650 ; s. 29-39
  • Bokkapitel (övrigt vetenskapligt)
  •  
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