SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lopez Lorna M.) srt2:(2017)"

Sökning: WFRF:(Lopez Lorna M.) > (2017)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
2.
  • Warren, Helen R., et al. (författare)
  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
  • 2017
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 49:3, s. 403-415
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
  •  
3.
  • Wain, Louise V., et al. (författare)
  • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
  • 2017
  • Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. E4-e19
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
  •  
4.
  • de Vries, Paul S., et al. (författare)
  • Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study
  • 2017
  • Ingår i: PLoS ONE. - 1932-6203. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were associated using both HapMap and 1000G imputation. One locus identified using HapMap imputation was not significant using 1000G imputation. The genome-wide significance threshold of 5x10(-8) is based on the number of independent statistical tests using HapMap imputation, and 1000G imputation may lead to further independent tests that should be corrected for. When using a stricter Bonferroni correction for the 1000G GWA study (P-value < 2.5x10(-8)), the number of loci significant only using HapMap imputation increased to 4 while the number of loci significant only using 1000G decreased to 5. In conclusion, 1000G imputation enabled the identification of 20% more loci than HapMap imputation, although the advantage of 1000G imputation became less clear when a stricter Bonferroni correction was used. More generally, our results provide insights that are applicable to the implementation of other dense reference panels that are under development.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Åtkomst
fritt online (1)
Typ av publikation
tidskriftsartikel (4)
Typ av innehåll
refereegranskat (4)
Författare/redaktör
Trompet, Stella, (4)
Lopez, Lorna M., (4)
Teumer, Alexander, (4)
Boomsma, Dorret I., (4)
Hofman, Albert, (4)
Psaty, Bruce M., (4)
visa fler...
Rotter, Jerome I., (4)
Stott, David J., (4)
Uitterlinden, Andre ... (4)
Deary, Ian J., (4)
Amin, Najaf, (3)
Bis, Joshua C., (3)
Chauhan, Ganesh, (3)
Hofer, Edith, (3)
Liewald, David C. M. ... (3)
Milaneschi, Yuri, (3)
Smith, Albert V., (3)
Gudnason, Vilmundur, (3)
Hartman, Catharina A ... (3)
Hottenga, Jouke-Jan, (3)
Jukema, J. Wouter, (3)
Penninx, Brenda W. J ... (3)
Schmidt, Reinhold, (3)
Tzourio, Christophe, (3)
Van Duijn, Cornelia ... (3)
Schmidt, Helena, (3)
Launer, Lenore J., (3)
Debette, Stephanie, (3)
Strachan, David P. (3)
Ridker, Paul M., (3)
Chasman, Daniel I., (3)
Rose, Lynda M (3)
Hamsten, Anders (3)
Khaw, Kay-Tee (2)
Lind, Lars, (2)
Raitakari, Olli T (2)
De Geus, Eco J. C., (2)
Ferrucci, Luigi, (2)
Hernandez, Dena G., (2)
De Craen, Anton J. M ... (2)
Enroth, Stefan, (2)
Wareham, Nicholas J. (2)
Johansson, Åsa, (2)
Langenberg, Claudia (2)
Paré, Guillaume (2)
Boehnke, Michael (2)
Scott, Robert A (2)
Ingelsson, Erik (2)
Shah, Nabi, (2)
Salomaa, Veikko (2)
visa färre...
Lärosäte
Karolinska Institutet (4)
Uppsala universitet (3)
Stockholms universitet (3)
Umeå universitet (1)
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (3)
Medicin och hälsovetenskap (3)
År
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy