| 1. |
- Mattsson, Stig-Arne, 1942-, et al.
(författare)
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Produktionslogistik 2003 effektivt flöde från leverantör till kund : artiklar från PLAN:s forsknings- och tillämpningskonferens i Luleå 28-29 augusti 2003
- 2003
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Bok (övrigt vetenskapligt)abstract
- Med produktionslogistik menas planering, utveckling, samordning, organisation, styrning och kontroll av det tillverkande företagets materialflöden och resursflöden med utgångspunkt från dess produktionssystem. I den här boken behandlas produktionslogistik som ett sätt att åstadkomma effektiva och konkurrenskraftiga företag. De första delarna av boken ger den teoretiska bakgrunden till i praktiken vanligt förekommande arbetssätt och planeringsmetoder. Med dessa delar vänder sig boken till studerande vid universitet och högskolor såväl som till konsulter och yrkesverksamma personer i industrin som vill ha en grundläggande genomgång av ämnesområdet. Den senare delen av boken innehåller fördjupningar inom ramen för de planeringsmetoder som översiktligt beskrivits i tidigare delar inklusive karakteristiska egenskaper och användningsmiljöer. Den delen av boken är avsedd att användas vid fördjupningsutbildning i produktionslogistik men också som ett hjälpmedel och en checklista vid val, utformning och användning av olika planeringsmetoder i praktiken.
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| 2. |
- Mattsson, Roger, et al.
(författare)
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Pulsed TV holography and schlieren studies, and large eddy simulations of a turbulent jet diffusion flame
- 2004
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Ingår i: Combustion and Flame. - Elsevier Inc.. - 0010-2180. ; 139:1-2
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Tidskriftsartikel (övrigt vetenskapligt)abstract
- In the search for an improved understanding of jet-flame dynamics we here compare predictions from large-eddy simulations (LES) and measurements using schlieren and holographic interferometry of a round turbulent jet diffusion flame. The studies concern a turbulent propane-air (C3H 8-O2/N2) diffusion flame under ambient conditions at a Reynolds number of Re=104. The interferometric measurements were performed with an all-electronic method, pulsed TV holography, using a pulsed laser and a fast charge coupled device (CCD) camera. The LES calculations use the probability density function (PDF) flamelet approach with a beta function as the probability density function, whereas the subgrid turbulence is modeled with a one-equation eddy viscosity model. In order to validate the LES model quantitative comparisons of first-order statistical moments of the velocity were first made with available data for nonreactive jets. The LES model captures the statistics well. The next step in the validation process concerns comparing the jet-flame development between LES and the schlieren and pulsed TV holography data. To this end the results of the LES calculations were used to simulate instantaneous interference patterns using ray tracing. The LES model describes the overall behavior of the flame successfully
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| 3. |
- Basu, Samar, et al.
(författare)
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Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock
- 2000
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Ingår i: Expert Opinion on Investigational Drugs. - 1354-3784. ; 9:5, s. 1129-1137
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Tidskriftsartikel (refereegranskat)abstract
- Sepsis and endotoxaemia initiate the generation of thrombin, which is responsible for the conversion of fibrinogen to fibrin, platelet aggregation and acts as an inflammatory mediator affecting numerous types of cells, including myocardial, smooth muscle and endothelial cells. Human Gram-negative septic shock, frequently seen in intensive care units, is a condition with high mortality. This condition can be replicated in the endotoxaemic pig. As many of the toxic effects of sepsis are due to thrombin generation, it was of interest to study, using this porcine experimental septic shock model, whether inhibition of thrombin could alleviate the effects of endotoxaemia. For this purpose melagatran, a direct synthetic thrombin inhibitor with a molecular weight of 429 Da, was employed. Melagatran does not significantly interact with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Furthermore, melagatran does not require endogenous co-factors such as antithrombin or heparin co-Factor II for its antithrombin effect, which is important, as these inhibitors are often consumed in septic patients. We have shown that melagatran exerts a beneficial effect on renal function, as evaluated by plasma creatinine and urinary output, during experimental septic shock. These effects were most pronounced during the later phase of the experimental period, after the infusion of melagatran had been discontinued. Prevention of intrarenal coagulation may be attributable to this finding. In addition, melagatran had beneficial effects on systemic haemodynamics (left ventricular stroke work index, pulmonary capillary wedge pressure and systemic vascular resistance index) in endotoxaemic pigs. This result may be explained by the ability of melagatran to inhibit thrombin, thereby counteracting thrombin's cellular effects. Thus, it can be seen, using this experimental model of septic shock, that melagatran may help to alleviate some of the damaging effects of endotoxaemia, although more research is required to test this further.
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| 4. |
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| 5. |
- Karlsson, Mikael, et al.
(författare)
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"Distributed proton radiation therapy"--a new concept for advanced competence support.
- 2006
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Ingår i: Acta oncologica (Stockholm, Sweden). - 0284-186X. ; 45:8, s. 1094
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Tidskriftsartikel (refereegranskat)abstract
- The increased interest in high precision radiation therapy is to a large extent driven by the potential of modern imaging technology. The aim of this project was to analyse how an expensive proton facility best could support a multi-centre health care system. We have developed a model for distributed expert collaboration where all clinical experts will work close to their patients in regional centres. Patients who are candidates for proton therapy will be examined and dose-planned at their regional clinic, discussed in a fully information supported video conference and digitally made available at the proton treatment facility. The proton facility itself will be placed near a communication centre easily reached by all patients where they will be treated under full responsibility of their own physician at the home clinic. This concept has been analysed in detail both with respect to the overall functionality and with respect to possible weaknesses. It was found that the concept of distributed radiation therapy, as proposed here, will offer a stable clinical solution for advanced radiation therapy. It will support the spread of knowledge, serve as a fully developed backup system and the concept will further serve as an efficient base for clinical research.
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| 6. |
- Mattsson, Roger, et al.
(författare)
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Laser ignition of premixed gases studied by pulsed TV holography
- 2003
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Ingår i: Speckle metrology 2003 : proceedings ; 18 - 20 June 2003, Trondheim, Norway. - Bellingham, Wash : SPIE - International Society for Optical Engineering. - 0-8194-4728-5 ; 285-290
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Annan publikation (populärvet., debatt m.m.)abstract
- Pulsed TV holography is an all-electronic version of pulsed holographic interferometry. Such a system was used to study ignition of pre-mixed flammable gases. The object was recorded in its undisturbed and disturbed state followed by an evaluation of the changes in refractive index field between those two states. The essential components of the set-up are an injection seeded, twin cavity double pulsed Nd:YAG laser and a CCD camera. A focused laser pulse from the same laser that was used for the recording of the digital hologram initiated the ignition of the pre-mixed gas. Results from the recordings show the ignition process. From the experimental phase maps the refractive index of the gas mixture could be determined. This method makes it possible to determine the proportion of components in a pre-mixed flammable gas in situ
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| 7. |
- Zetterberg, Henrik, 1973-, et al.
(författare)
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Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years.
- 2007
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Ingår i: Journal of Alzheimer's disease : JAD. - 1387-2877. ; 12:3, s. 255-60
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical and neuropsychological evaluation and lumbar puncture at baseline and after 2 years at a university hospital memory clinic. CSF was analyzed for total tau (T-tau), phospho-tau(181) (P-tau(181)) and amyloid-beta(1-42) (Abeta(1-42)). During the 2-year observational time, 12 MCI patients progressed to AD and 3 progressed to vascular dementia, while 68 remained stable. Baseline T-tau and P-tau(181) levels were elevated in the MCI-AD group as compared to the stable MCI patients and the control group (p<0.01), while baseline Abeta(1-42) levels were lower (p<0.001). Stable MCI patients were biochemically indistinguishable from controls. The biomarker levels at baseline and after 2 years showed Pearson R values between 0.81 and 0.91 (p<0.001) and coefficients of variation of 7.2 to 8.7%. In conclusion, intra-individual biomarker levels are remarkably stable over 2 years. Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials.
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| 8. |
- Åström-Olsson, Karin, 1959-, et al.
(författare)
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Dissociation of the Inflammatory Reaction following PCI for Acute Myocardial Infarction
- 2007
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Ingår i: The Journal of invasive cardiology. - HMP Communications. - 1042-3931. ; 19:11, s. 452-456
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Neutrophils are activated and infiltrate the myocardium after ischemia and reperfusion. The involvement of neutrophils in irreversible reperfusion injury is suggested by numerous experimental studies. The aim of this study was to investigate markers of neutrophil activation following reperfusion of acute myocardial infarction (AMI) accomplished with percutaneous coronary intervention (PCI) and their relationship to markers of lipid peroxidation, cytokines and highly-sensitive C-reactive protein (hsCRP). DESIGN: Non-consecutive patients with their first myocardial infarction were evaluated. Setting. University hospital as primary referral center, single center. PATIENTS AND METHODS: Forty-nine patients with AMI were evaluated. All were treated with primary PCI and infusion of abciximab. Reperfusion was verified by angiography. Blood samples for analyses of myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), malondialdehyde (MDA), 8-isoprostane-prostaglandin F2alpha (Iso-P), interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factoralpha (TNFalpha), hsCRP, creatine kinase-monobasic fraction (CK-MB) and troponin-T (TnT) were obtained at baseline with the occluded coronary vessel, and subsequently after verified reperfusion at 1.5, 3 and 24 hours. RESULTS: Significant increases in MMP-9, IL-6, IL-8, TNFalpha and hsCRP were observed, and a significant decrease in MPO and MDA was also observed over the same period. No significant changes in Iso-P and NGAL were found. CONCLUSION: We found a dissociation of the inflammatory reaction after PCI for AMI: a decrease of markers of neutrophil activation and MDA, but an increase in cytokines and hsCRP. An antineutrophil effect of the PCI procedure including treatment with abciximab, an antiplatelet drug and a modulator of inflammation, is conceivable.
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| 9. |
- Abs, Roger, et al.
(författare)
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Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis.
- 2006
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Ingår i: European Journal of Endocrinology. - 0804-4643. ; 155:1, s. 79-90
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of the present study was to clarify the relationship between GH deficiency (GHD) andsome cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large numberof patients over a prolonged period of time.Design: Data for analysis were retrieved from KIMS (Pfizer International Metabolic Database). Serumconcentrations of total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein(LDL)-cholesterol and triglycerides were obtained from 2589 patients at baseline and from 1206patients after 1 and 2 years of GH replacement therapy. Body mass index (BMI), waist and hip, restingblood pressure and body composition were also measured.Results: At baseline, the unfavourable effects of GHD were most obvious in the lipid profiledemonstrating elevated mean total and LDL-cholesterol, in the increased waist circumference and theelevated BMI. The cholesterol concentration, BMI and body composition were significantly adverselyaffected by a number of factors, including age, sex and the use of anti-epileptic drugs. The therapeuticeffect of GH was essentially uniform across the whole population. GH replacement reduced significantlythe mean total and LDL-cholesterol, the waist circumference and the fat mass and was maintainedduring 2 years.Conclusions: This analysis of a large number of patients confirmed that GHD adults present with anincreased cardiovascular risk. The sustained improvement of the adverse lipid profile and bodycomposition suggests that GH replacement therapy may reduce the risk of cardiovascular disease andthe premature mortality seen in hypopituitary patients with untreated GHD.
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