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  • Alexander, Stephen P H, et al. (författare)
  • The Concise Guide to PHARMACOLOGY 2013/14 : overview.
  • 2013
  • Ingår i: British Journal of Pharmacology. - 0007-1188. ; 170:8, s. 1449-58
  • Tidskriftsartikel (refereegranskat)abstract
    • The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties from the IUPHAR database. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. This compilation of the major pharmacological targets is divided into seven areas of focus: G protein-coupled receptors, ligand-gated ion channels, ion channels, catalytic receptors, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors & Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
  • de Graauw, T., et al. (författare)
  • The Herschel-Heterodyne Instrument for the Far-Infrared (HIFI)
  • 2010
  • Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 518, s. 7-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI) that was launched onboard ESA's Herschel Space Observatory in May 2009. Methods: The instrument is a set of 7 heterodyne receivers that are electronically tuneable, covering 480-1250 GHz with SIS mixers and the 1410-1910 GHz range with hot electron bolometer (HEB) mixers. The local oscillator (LO) subsystem comprises a Ka-band synthesizer followed by 14 chains of frequency multipliers and 2 chains for each frequency band. A pair of auto-correlators and a pair of acousto-optical spectrometers process the two IF signals from the dual-polarization, single-pixel front-ends to provide instantaneous frequency coverage of 2 × 4 GHz, with a set of resolutions (125 kHz to 1 MHz) that are better than 0.1 km s-1. Results: After a successful qualification and a pre-launch TB/TV test program, the flight instrument is now in-orbit and completed successfully the commissioning and performance verification phase. The in-orbit performance of the receivers matches the pre-launch sensitivities. We also report on the in-orbit performance of the receivers and some first results of HIFI's operations. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.
  • Ackermann, M., et al. (författare)
  • Fermi Detection of γ-Ray Emission from the M2 Soft X-Ray Flare on 2010 June 12
  • 2012
  • Ingår i: Astrophysical Journal. - 0004-637X. ; 745:2, s. 144
  • Tidskriftsartikel (refereegranskat)abstract
    • The Geostationary Operational Environmental Satellite (GOES) M2-class solar flare, SOL2010-06-12T00: 57, was modest in many respects yet exhibited remarkable acceleration of energetic particles. The flare produced an similar to 50 s impulsive burst of hard X-and gamma-ray emission up to at least 400 MeV observed by the Fermi Gamma-ray Burst Monitor and Large Area Telescope experiments. The remarkably similar hard X-ray and high-energy gamma-ray time profiles suggest that most of the particles were accelerated to energies greater than or similar to 300 MeV with a delay of similar to 10 s from mildly relativistic electrons, but some reached these energies in as little as similar to 3 s. The gamma-ray line fluence from this flare was about 10 times higher than that typically observed from this modest GOES class of X-ray flare. There is no evidence for time-extended >100 MeV emission as has been found for other flares with high-energy gamma-rays.
  • Kähler, Anna, et al. (författare)
  • Biological insights from 108 schizophrenia-associated genetic loci
  • 2014
  • Ingår i: Nature. - 0028-0836. ; 511:7510, s. 421-
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
  • Lis, D. C., et al. (författare)
  • Herschel/HIFI discovery of interstellar chloronium (H2Cl+)
  • 2010
  • Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 521
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the first detection of chloronium, H2Cl+, in the interstellar medium, using the HIFI instrument aboard the Herschel Space Observatory. The 212–101 lines of ortho-H<img src="http://www.aanda.org/articles/aa/abs/2010/13/aa14959-10/aa14959-10_tex_eq1.png" />Cl+ and ortho-H<img src="http://www.aanda.org/articles/aa/abs/2010/13/aa14959-10/aa14959-10_tex_eq2.png" />Cl+ are detected in absorption towards NGC 6334I, and the 111–000 transition of para-H<img src="http://www.aanda.org/articles/aa/abs/2010/13/aa14959-10/aa14959-10_tex_eq1.png" />Cl+ is detected in absorption towards NGC 6334I and Sgr B2(S). The H2Cl+ column densities are compared to those of the chemically-related species HCl. The derived HCl/H2Cl+ column density ratios, ~1–10, are within the range predicted by models of diffuse and dense photon dominated regions (PDRs). However, the observed H2Cl+ column densities, in excess of 1013 cm-2, are significantly higher than the model predictions. Our observations demonstrate the outstanding spectroscopic capabilities of HIFI for detecting new interstellar molecules and providing key constraints for astrochemical models.
  • Werren, John H, et al. (författare)
  • Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.
  • 2010
  • Ingår i: Science. - 0036-8075. ; 327:5963, s. 343-8
  • Tidskriftsartikel (refereegranskat)abstract
    • We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation. Newly developed genome resources advance Nasonia for genetic research, accelerate mapping and cloning of quantitative trait loci, and will ultimately provide tools and knowledge for further increasing the utility of parasitoids as pest insect-control agents.
  • Grieser, M., et al. (författare)
  • Storage ring at HIE-ISOLDE Technical design report
  • 2012
  • Ingår i: European Physical Journal: Special Topics. - Springer. - 1951-6355. ; 207:1, s. 1-117
  • Forskningsöversikt (refereegranskat)abstract
    • We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
  • Gupta, H., et al. (författare)
  • Detection of OH+ and H2O+ towards Orion KL
  • 2010
  • Ingår i: Astronomy and Astrophysics. - 0004-6361. ; 521, s. L47
  • Tidskriftsartikel (refereegranskat)abstract
    • We report observations of the reactive molecular ions OH+, H2O+, and H3O+ towards Orion KL with Herschel/HIFI. All three N = 1-0 fine-structure transitions of OH+ at 909, 971, and 1033 GHz and both fine-structure components of the doublet ortho-H2O+ 111-000 transition at 1115 and 1139 GHz were detected; an upper limit was obtained for H3O+. OH+ and H2O+ are observed purely in absorption, showing a narrow component at the source velocity of 9 km s-1, and a broad blueshifted absorption similar to that reported recently for HF and para-H218O, and attributed to the low velocity outflow of Orion KL. We estimate column densities of OH+ and H2O+ for the 9 km s-1 component of 9 ± 3 × 1012 cm-2 and 7 ± 2 × 1012 cm-2, and those in the outflow of 1.9 ± 0.7 × 1013 cm-2 and 1.0 ± 0.3 × 1013 cm-2. Upper limits of 2.4 × 1012 cm-2 and 8.7 × 1012 cm-2 were derived for the column densities of ortho and para-H3O+ from transitions near 985 and 1657 GHz. The column densities of the three ions are up to an order of magnitude lower than those obtained from recent observations of W31C and W49N. The comparatively low column densities may be explained by a higher gas density despite the assumption of a very high ionization rate.
  • Lis, D. C., et al. (författare)
  • Herschel/HIFI measurements of the ortho/para ratio in water towards Sagittarius B2(M) and W31C
  • 2010
  • Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 521
  • Tidskriftsartikel (refereegranskat)abstract
    • We present Herschel/HIFI observations of the fundamental rotational transitions of ortho- and para-H216O and H218O in absorption towards Sagittarius B2(M) and W31C. The ortho/para ratio in water in the foreground clouds on the line of sight towards these bright continuum sources is generally consistent with the statistical high-temperature ratio of 3, within the observational uncertainties. However, somewhat unexpectedly, we derive a low ortho/para ratio of 2.35 +/- 0.35, corresponding to a spin temperature of similar to 27 K, towards Sagittarius B2(M) at velocities of the expanding molecular ring. Water molecules in this region appear to have formed with, or relaxed to, an ortho/para ratio close to the value corresponding to the local temperature of the gas and dust.
  • Qin, S. -L, et al. (författare)
  • Herschel observations of EXtra-Ordinary Sources (HEXOS):
  • 2010
  • Ingår i: Astronomy & Astrophysics. - 0004-6361. ; 521
  • Tidskriftsartikel (refereegranskat)abstract
    • We have observed CH absorption lines (J = 3/2, N = 1 &lt;- J = 1/2, N = 1) against the continuum source Sgr B2(M) using the Herschel/HIFI instrument. With the high spectral resolution and wide velocity coverage provided by HIFI, 31 CH absorption features with different radial velocities and line widths are detected and identified. The narrower line width and lower column density clouds show "spiral arm" cloud characteristics, while the absorption component with the broadest line width and highest column density corresponds to the gas from the Sgr B2 envelope. The observations show that each "spiral arm" harbors multiple velocity components, indicating that the clouds are not uniform and that they have internal structure. This line-of-sight through almost the entire Galaxy offers unique possibilities to study the basic chemistry of simple molecules in diffuse clouds, as a variety of different cloud classes are sampled simultaneously. We find that the linear relationship between CH and H-2 column densities found at lower AV by UV observations does not continue into the range of higher visual extinction. There, the curve flattens, which probably means that CH is depleted in the denser cores of these clouds.
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