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Sökning: WFRF:(Nielsen Jörn) > Wierzbicka Aneta

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  • Dierschke, Katrin, et al. (författare)
  • Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates
  • 2017
  • Ingår i: International Archives of Occupational and Environmental Health. - Springer. - 1432-1246.
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Welders are exposed to airborne particles from the welding environment and often develop symptoms work-related from the airways. A large fraction of the particles from welding are in the nano-size range. In this study we investigate if the welders' airways are affected by exposure to particles derived from gas metal arc welding in mild steel in levels corresponding to a normal welding day.METHOD: In an exposure chamber, 11 welders with and 10 welders without work-related symptoms from the lower airways and 11 non-welders without symptoms, were exposed to welding fumes (1 mg/m(3)) and to filtered air, respectively, in a double-blind manner. Symptoms from eyes and upper and lower airways and lung function were registered. Blood and nasal lavage (NL) were sampled before, immediately after and the morning after exposure for analysis of markers of oxidative stress. Exhaled breath condensate (EBC) for analysis of leukotriene B4 (LT-B4) was sampled before, during and immediately after exposure.RESULTS: No adverse effects of welding exposure were found regarding symptoms and lung function. However, EBC LT-B4 decreased significantly in all participants after welding exposure compared to filtered air. NL IL-6 increased immediately after exposure in the two non-symptomatic groups and blood neutrophils tended to increase in the symptomatic welder group. The morning after, neutrophils and serum IL-8 had decreased in all three groups after welding exposure. Remarkably, the symptomatic welder group had a tenfold higher level of EBC LT-B4 compared to the two groups without symptoms.CONCLUSION: Despite no clinical adverse effects at welding, changes in inflammatory markers may indicate subclinical effects even at exposure below the present Swedish threshold limit (8 h TWA respirable dust).
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  • Hagerman, Inger, et al. (författare)
  • Effects of exposure to indoor nano-sized particles on heart rate variability
  • 2011
  • Annan publikation (övrigt vetenskapligt)abstract
    • Background Airborne particles are associated with increased morbidity and mortality due to respiratory and cardiovascular diseases in polluted areas. There is a growing interest in fine particles with diameter < 100 nm and their potential health effects. Heart rate variability (HRV) is a noninvasive method for cardiovascular risk prediction in high prevalent groups. Aim of study To evaluate the impact of nano-sized indoor air particles on HRV. Methods All exposures were performed as controlled chamber experiments with particle exposure from burning candles, terpene+ozone-reactions or filtered air in a double-blind cross over fashion. 22 healthy females were investigated during 10 minute periods at different exposures and HRV were computed for various spectral components. Results Heart rate was unchanged from baseline values in all groups during all experimental settings. Compared to filtered air, burning candle tended to decrease the power in both high (HF) and low (LF) spectral band but only in HF during terpene+ozone. Conclusions Exposure to nano-sized particles of burning candles or terpene+ozone seem to have an impact on heart rate variability, mediated by different aspects of autonomic cardiovascular control. Practical implications This study indicate that the HRV method may be used for information on physiological response of exposure different nano-sized particles and contribute to the understanding of mechanisms behind effects of particle exposures
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